scholarly journals Peptide:glycosaminoglycan hybrid hydrogels as an injectable intervention for spinal disc degeneration

2016 ◽  
Vol 4 (19) ◽  
pp. 3225-3231 ◽  
Author(s):  
D. E. Miles ◽  
E. A. Mitchell ◽  
N. Kapur ◽  
P. A. Beales ◽  
R. K. Wilcox
Keyword(s):  
Mechanical Properties ◽  
Disc Degeneration ◽  
Self Assembly ◽  
Hybrid Gels ◽  
Hybrid Hydrogels ◽  
Spinal Disc

Peptide and glycosaminoglycan hybrid gels undergo self-assembly and result in tuneable mechanical properties with suitability for intradiscal treatments.

The mechanical properties of polymer–colloid hybrid hydrogels

Soft Matter ◽  
2017 ◽  
Vol 13 (27) ◽  
pp. 4786-4790 ◽  
Author(s):  
H. Dehne ◽  
F. M. Hecht ◽  
A. R. Bausch
Keyword(s):  
Mechanical Properties ◽  
Functional Properties ◽  
Colloidal Particles ◽  
Hybrid Gels ◽  
Hybrid Hydrogels ◽  
Polymer Colloid

The incorporation of monodisperse colloidal particles in hydrogels is a promising approach to create hybrid gels with unique structural, mechanical and functional properties.

scholarly journals Stimuli-Responsive Nucleotide–Amino Acid Hybrid Supramolecular Hydrogels

Gels ◽  
2021 ◽  
Vol 7 (3) ◽  
pp. 146
Author(s):  
Matthew Mulvee ◽  
Natasa Vasiljevic ◽  
Stephen Mann ◽  
Avinash J. Patil
Keyword(s):  
Mechanical Properties ◽  
Amino Acid ◽  
Self Assembly ◽  
Soft Materials ◽  
Guanosine Monophosphate ◽  
Molar Ratio ◽  
Stimuli Responsive ◽  
Molar Ratios ◽  
Hybrid Hydrogels ◽  
Guanine Residue

The ability to assemble chemically different gelator molecules into complex supramolecular hydrogels provides excellent opportunities to construct functional soft materials. Herein, we demonstrate the formation of hybrid nucleotide–amino acid supramolecular hydrogels. These are generated by the silver ion (Ag+)-triggered formation of silver–guanosine monophosphate (GMP) dimers, which undergo self-assembly through non-covalent interactions to produce nanofilaments. This process results in a concomitant pH reduction due to the abstraction of a proton from the guanine residue, which triggers the in situ gelation of a pH-sensitive amino acid, N-fluorenylmethyloxycarbonyl tyrosine (FY), to form nucleotide–amino acid hybrid hydrogels. Alterations in the supramolecular structures due to changes in the assembly process are observed, with the molar ratio of Ag:GMP:FY affecting the assembly kinetics, and the resulting supramolecular organisation and mechanical properties of the hydrogels. Higher Ag:GMP stoichiometries result in almost instantaneous gelation with non-orthogonal assembly of the gelators, while at lower molar ratios, orthogonal assembly is observed. Significantly, by increasing the pH as an external stimulus, nanofilaments comprising FY can be selectively disassembled from the hybrid hydrogels. Our results demonstrate a simple approach for the construction of multicomponent stimuli-responsive supramolecular hydrogels with adaptable network and mechanical properties.

Polypyrrole/PU hybrid hydrogels: electrically conductive and fast self-healing for the potential application in body-monitor sensor

2021 ◽  
Author(s):  
Zhanyu Jia ◽  
Guangyao Li ◽  
Juan Wang ◽  
shouhua Su ◽  
Jie Wen ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Electrical Conductivity ◽  
Potential Application ◽  
Self Healing ◽  
Electrically Conductive ◽  
Sensor Application ◽  
Hybrid Hydrogels ◽  
Health Monitor

Conductivity, self-healing and moderate mechanical properties are necessary for multifunctional hydrogels which have great potential in health-monitor sensor application. However, the combination of electrical conductivity, self-healing and good mechanical properties...

scholarly journals Nanostructure, Self-Assembly, Mechanical Properties, and Antioxidant Activity of a Lupin-Derived Peptide Hydrogel

Biomedicines ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 294
Author(s):  
Raffaele Pugliese ◽  
Anna Arnoldi ◽  
Carmen Lammi
Keyword(s):  
Mechanical Properties ◽  
Antioxidant Activity ◽  
Self Assembly ◽  
Antioxidant Activities ◽  
Functional Materials ◽  
Cd Spectroscopy ◽  
Beneficial Effects ◽  
Naturally Occurring ◽  
New Research ◽  
Peptide Hydrogel

Naturally occurring food peptides are frequently used in the life sciences due to their beneficial effects through their impact on specific biochemical pathways. Furthermore, they are often leveraged for applications in areas as diverse as bioengineering, medicine, agriculture, and even fashion. However, progress toward understanding their self-assembling properties as functional materials are often hindered by their long aromatic and charged residue-enriched sequences encrypted in the parent protein sequence. In this study, we elucidate the nanostructure and the hierarchical self-assembly propensity of a lupin-derived peptide which belongs to the α-conglutin (11S globulin, legumin-like protein), with a straightforward N-terminal biotinylated oligoglycine tag-based methodology for controlling the nanostructures, biomechanics, and biological features. Extensive characterization was performed via Circular Dichroism (CD) spectroscopy, Fourier Transform Infrared spectroscopy (FT-IR), rheological measurements, and Atomic Force Microscopy (AFM) analyses. By using the biotin tag, we obtained a thixotropic lupin-derived peptide hydrogel (named BT13) with tunable mechanical properties (from 2 to 11 kPa), without impairing its spontaneous formation of β-sheet secondary structures. Lastly, we demonstrated that this hydrogel has antioxidant activity. Altogether, our findings address multiple challenges associated with the development of naturally occurring food peptide-based hydrogels, offering a new tool to both fine tune the mechanical properties and tailor the antioxidant activities, providing new research directions across food chemistry, biochemistry, and bioengineering.

Tuneable Hybrid Hydrogels via Complementary Self-Assembly of a Bioactive Peptide with a Robust Polysaccharide

2021 ◽  
Author(s):  
Kate Firipis ◽  
Mitchell Boyd-Moss ◽  
Benjamin Long ◽  
Chaitali Dekiwadia ◽  
William Hoskin ◽  
...  
Keyword(s):  
Self Assembly ◽  
Bioactive Peptide ◽  
Hybrid Hydrogels

Self-assembled three-dimensional hierarchical graphene hybrid hydrogels with ultrathin β-MnO2 nanobelts for high performance supercapacitors

2015 ◽  
Vol 3 (4) ◽  
pp. 1540-1548 ◽  
Author(s):  
Sheng Zhu ◽  
Hui Zhang ◽  
Ping Chen ◽  
Lin-Hui Nie ◽  
Chuan-Hao Li ◽  
...  
Keyword(s):  
Self Assembly ◽  
High Performance ◽  
Three Dimensional ◽  
The Self ◽  
Mass Loading ◽  
Hybrid Hydrogel ◽  
Precise Control ◽  
Ultrafine Structure ◽  
Hybrid Hydrogels ◽  
Self Assembled

A facile protocol for the self-assembly of the rGO/β-MnO2 hybrid hydrogel with ultrafine structure and precise control of mass-loading for high performance supercapacitors is reported.

Magnetic Resonance Elastography for the Measurement of Annulus Fibrosus Material Properties

2011 ◽  
Author(s):  
Daniel H. Cortes ◽  
Lachlan J. Smith ◽  
Sung M. Moon ◽  
Jeremy F. Magland ◽  
Alexander C. Wright ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Magnetic Resonance ◽  
Shear Modulus ◽  
Disc Degeneration ◽  
Annulus Fibrosus ◽  
Pulse Sequence ◽  
Imaging Techniques ◽  
Mechanical Vibration ◽  
Magnetic Resonance Elastography

Intervertebral disc degeneration is characterized by a progressive cascade of structural, biochemical and biomechanical changes affecting the annulus fibrosus (AF), nucleus pulposus (NP) and end plates (EP). These changes are considered to contribute to the onset of back pain. It has been shown that mechanical properties of the AF and NP change significantly with degeneration [1,2]. Therefore, mechanical properties have the potential to serve as a biomarker for diagnosis of disc degeneration. Currently, disc degeneration is diagnosed based on the detection of structural and compositional changes using MRI, X-ray, discography and other imaging techniques. These methods, however, do not measure directly the mechanical properties of the extracellular matrix of the disc. Magnetic Resonance Elastography (MRE) is a technique that has been used to measure in vivo mechanical properties of soft tissue by applying a mechanical vibration and measuring displacements with a motion-sensitized MRI pulse sequence [3]. The mechanical properties (e.g., the shear modulus) are calculated from the displacement field using an inverse method. Since the applied displacements are in the order of few microns, fibers may not be stretched enough to remove crimping. Therefore, it is unknown if the anisotropy of the AF due to the contribution of the fibers is detectable using MRE. The objective of this study is twofold: to measure shear properties of AF in different orientations to determine the degree of AF anisotropy observable by MRE, and to identify the contribution of different AF constituents to the measured shear modulus by applying different biochemical treatments.

Flexible, conductive, porous, fibrillar polymer–gold nanocomposites with enhanced electromagnetic interference shielding and mechanical properties

2017 ◽  
Vol 5 (5) ◽  
pp. 1095-1105 ◽  
Author(s):  
Jun Li ◽  
Hu Liu ◽  
Jiang Guo ◽  
Zhen Hu ◽  
Zhijiang Wang ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Gold Nanoparticles ◽  
Self Assembly ◽  
Electromagnetic Interference ◽  
Shielding Effectiveness ◽  
Emi Shielding ◽  
Electromagnetic Interference Shielding ◽  
Emi Shielding Effectiveness ◽  
Conductive Nanocomposites ◽  
Gold Nanocomposites

Flexible lightweight conductive nanocomposites prepared by self-assembly of gold nanoparticles on charged polymer nanofibers show enhanced EMI shielding effectiveness and mechanical properties.

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