scholarly journals The effect of active fluctuations on the dynamics of particles, motors and DNA-hairpins

Soft Matter ◽  
2017 ◽  
Vol 13 (11) ◽  
pp. 2181-2191 ◽  
Author(s):  
Hans Vandebroek ◽  
Carlo Vanderzande
Keyword(s):  
Dna Hairpins ◽  
Dynamics Of Particles

Effect of loop sequence on unzipping of short DNA hairpins

2021 ◽  
Vol 103 (6) ◽  
Author(s):  
Anurag Upadhyaya ◽  
Sanjay Kumar
Keyword(s):  
Dna Hairpins ◽  
Loop Sequence

scholarly journals Spatiotemporally programmable cascade hybridization of hairpin DNA in polymeric nanoframework for precise siRNA delivery

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Feng Li ◽  
Wenting Yu ◽  
Jiaojiao Zhang ◽  
Yuhang Dong ◽  
Xiaohui Ding ◽  
...  
Keyword(s):  
Steric Effect ◽  
Sirna Delivery ◽  
Dna Nanotechnology ◽  
Hybridization Chain Reaction ◽  
Dna Nanostructures ◽  
Chain Reaction ◽  
Dna Hairpins ◽  
In Vivo Experiments ◽  
Dna And Rna

AbstractDNA nanostructures have been demonstrated as promising carriers for gene delivery. In the carrier design, spatiotemporally programmable assembly of DNA under nanoconfinement is important but has proven highly challenging due to the complexity–scalability–error of DNA. Herein, a DNA nanotechnology-based strategy via the cascade hybridization chain reaction (HCR) of DNA hairpins in polymeric nanoframework has been developed to achieve spatiotemporally programmable assembly of DNA under nanoconfinement for precise siRNA delivery. The nanoframework is prepared via precipitation polymerization with Acrydite-DNA as cross-linker. The potential energy stored in the loops of DNA hairpins can overcome the steric effect in the nanoframework, which can help initiate cascade HCR of DNA hairpins and achieve efficient siRNA loading. The designer tethering sequence between DNA and RNA guarantees a triphosadenine triggered siRNA release specifically in cellular cytoplasm. Nanoframework provides stability and ease of functionalization, which helps address the complexity–scalability–error of DNA. It is exemplified that the phenylboronate installation on nanoframework enhanced cellular uptake and smoothed the lysosomal escape. Cellular results show that the siRNA loaded nanoframework down-regulated the levels of relevant mRNA and protein. In vivo experiments show significant therapeutic efficacy of using siPLK1 loaded nanoframework to suppress tumor growth.

scholarly journals IARD 2012: 8th Biennial Conference on Classical and Quantum Relativistic Dynamics of Particles and Fields

2013 ◽  
Vol 437 ◽  
pp. 011001
Author(s):  
L P Horwitz ◽  
Martin C Land ◽  
Tepper Gill ◽  
Luca Lusanna ◽  
Diana Nicmorus
Keyword(s):  
Relativistic Dynamics ◽  
Biennial Conference ◽  
Dynamics Of Particles

Renormalization group approach to quantum Hamiltonian dynamics

2015 ◽  
Vol 30 (09) ◽  
pp. 1530023 ◽  
Author(s):  
Stanisław D. Głazek
Keyword(s):  
Renormalization Group ◽  
Quantum Dynamics ◽  
Broad Class ◽  
Hamiltonian Dynamics ◽  
Group Approach ◽  
Physical Problems ◽  
Minkowski Space Time ◽  
Renormalization Group Approach ◽  
Effective Theories ◽  
Dynamics Of Particles

Ken Wilson developed powerful renormalization group procedures for constructing effective theories and solving a broad class of difficult physical problems. His insights allowed him to later advance the Hamiltonian approach to quantum dynamics of particles and fields in the Minkowski space–time, motivated by QCD. The latter advances are described in this article, concluding with a remark on Ken's related interest in difficult systemic issues of society.

Effect of hairpin loop structure on reactivity, sequence preference and adduct orientation of a DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumour agent

2015 ◽  
Vol 13 (13) ◽  
pp. 4031-4040 ◽  
Author(s):  
David E. Thurston ◽  
Higia Vassoler ◽  
Paul J. M. Jackson ◽  
Colin H. James ◽  
Khondaker M. Rahman
Keyword(s):  
Structural Flexibility ◽  
Loop Structure ◽  
Hairpin Loop ◽  
Dna Hairpins ◽  
Sequence Preference ◽  
Antitumour Agent

Pyrrolobenzodiazepine (PBD) monomer GWL-78 reacts faster with DNA hairpins containing a hexaethylene glycol (HEG) loop compared to hairpins containing a TTT loop due to the greater structural flexibility of the HEG.

Comparative Review. Classical Dynamics of Particles and Systems, 4th ed.

2000 ◽  
Vol 68 (4) ◽  
pp. 390-393 ◽  
Author(s):  
Jerry Marion ◽  
Stephen Thornton ◽  
R. W. Robinett
Keyword(s):  
Classical Dynamics ◽  
Comparative Review ◽  
Dynamics Of Particles
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