scholarly journals Circulatory zinc transport is controlled by distinct interdomain sites on mammalian albumins

2016 ◽  
Vol 7 (11) ◽  
pp. 6635-6648 ◽  
Author(s):  
Katarzyna B. Handing ◽  
Ivan G. Shabalin ◽  
Omar Kassaar ◽  
Siavash Khazaipoul ◽  
Claudia A. Blindauer ◽  
...  
Keyword(s):  
Serum Albumin ◽  
Crystal Structures ◽  
Zinc Binding ◽  
Zinc Transport ◽  
Binding Data ◽  
Essential Nutrient

Circulatory transport of the essential nutrient zinc primarily occurs through its binding to serum albumin. Here, we present the first crystal structures of mammalian albumins in complex with zinc. These structures, together with accompanying zinc binding data, allow identification of key zinc transport sites on human and equine albumins.

Albumin as a zinc carrier: properties of its high-affinity zinc-binding site

2008 ◽  
Vol 36 (6) ◽  
pp. 1317-1321 ◽  
Author(s):  
Jin Lu ◽  
Alan J. Stewart ◽  
Peter J. Sadler ◽  
Teresa J.T. Pinheiro ◽  
Claudia A. Blindauer
Keyword(s):  
Fatty Acid ◽  
Serum Albumin ◽  
Molecular Mechanisms ◽  
Zinc Binding ◽  
Serum Albumins ◽  
Fatty Acid Binding ◽  
Zinc Binding Site ◽  
Essential Nutrient ◽  
The Subject ◽  
Zinc Site

Although details of the molecular mechanisms for the uptake of the essential nutrient zinc into the bloodstream and its subsequent delivery to zinc-requiring organs and cells are poorly understood, it is clear that in vertebrates the majority of plasma zinc (9–14 μM; approx. 75–85%) is bound to serum albumin, constituting part of the so-called exchangeable pool. The binding of metal ions to serum albumins has been the subject of decades of studies, employing a multitude of techniques, but only recently has the identity and putative structure of the major zinc site on albumin been reported. Intriguingly, this site is located at the interface between two domains, and involves two residues from each of domains I and II. Comparisons of X-ray crystal structures of free and fatty-acid bound human serum albumin suggest that zinc binding to this site and fatty acid binding to one of the five major sites may be interdependent. Interactive binding of zinc and long-chain fatty acids to albumin may therefore have physiological implications.

High-resolution Crystal Structures of Erythrina cristagalli Lectin in Complex with Lactose and 2′-α-l-Fucosyllactose and Correlation with Thermodynamic Binding Data

2002 ◽  
Vol 321 (1) ◽  
pp. 69-83 ◽  
Author(s):  
Cecilia Svensson ◽  
Susann Teneberg ◽  
Carol L. Nilsson ◽  
Anders Kjellberg ◽  
Frederick P. Schwarz ◽  
...  
Keyword(s):  
High Resolution ◽  
Crystal Structures ◽  
Binding Data

Crystal Structures of Human Tissue Kallikrein 4: Activity Modulation by a Specific Zinc Binding Site

2006 ◽  
Vol 362 (5) ◽  
pp. 1094-1107 ◽  
Author(s):  
Mekdes Debela ◽  
Viktor Magdolen ◽  
Valerie Grimminger ◽  
Christian Sommerhoff ◽  
Albrecht Messerschmidt ◽  
...  
Keyword(s):  
Binding Site ◽  
Crystal Structures ◽  
Human Tissue ◽  
Zinc Binding ◽  
Tissue Kallikrein ◽  
Zinc Binding Site ◽  
Kallikrein 4

Crystal structures of human serum albumin complexed with monounsaturated and polyunsaturated fatty acids

2001 ◽  
Vol 314 (5) ◽  
pp. 955-960 ◽  
Author(s):  
Isabelle Petitpas ◽  
Tim Grüne ◽  
Ananyo A Bhattacharya ◽  
Stephen Curry
Keyword(s):  
Fatty Acids ◽  
Human Serum Albumin ◽  
Polyunsaturated Fatty Acids ◽  
Serum Albumin ◽  
Human Serum ◽  
Crystal Structures

scholarly journals Crystal Structures of the Mnk2 Kinase Domain Reveal an Inhibitory Conformation and a Zinc Binding Site

Structure ◽  
2005 ◽  
Vol 13 (10) ◽  
pp. 1559-1568 ◽  
Author(s):  
Ralf Jauch ◽  
Stefan Jäkel ◽  
Catharina Netter ◽  
Kay Schreiter ◽  
Babette Aicher ◽  
...  
Keyword(s):  
Binding Site ◽  
Crystal Structures ◽  
Kinase Domain ◽  
Zinc Binding ◽  
Zinc Binding Site
Sign in / Sign up

Export Citation Format

Share Document