scholarly journals Metal-free disproportionation of formic acid mediated by organoboranes

2016 ◽  
Vol 7 (9) ◽  
pp. 5680-5685 ◽  
Author(s):  
Clément Chauvier ◽  
Pierre Thuéry ◽  
Thibault Cantat
Keyword(s):  
Formic Acid ◽  
Mechanistic Studies ◽  
Metal Free ◽  
Aldehyde Reduction

In the presence of dialkylboranes, formic acid is converted to formaldehyde and methanol derivatives. This is the first example of formate disproportionation under metal-free conditions. Mechanistic studies highlight the role of transient borohydrides in the reduction of formates and this is further shown in transfer hydroboration for aldehyde reduction.

scholarly journals Unveiling the role of boroxines in metal-free carbon–carbon homologations using diazo compounds and boronic acids

2017 ◽  
Vol 8 (9) ◽  
pp. 6071-6075 ◽  
Author(s):  
Claudio Bomio ◽  
Mikhail A. Kabeshov ◽  
Arthur R. Lit ◽  
Shing-Hing Lau ◽  
Janna Ehlert ◽  
...  
Keyword(s):  
Boronic Acids ◽  
Free Carbon ◽  
Diazo Compounds ◽  
Mechanistic Studies ◽  
Metal Free

By means of computational and experimental mechanistic studies the fundamental role of boroxines in the reaction between diazo compounds and boronic acids was elucidated.

scholarly journals Role of defects in carbon materials during metal-free formic acid dehydrogenation

Nanoscale ◽  
2020 ◽  
Vol 12 (44) ◽  
pp. 22768-22777
Author(s):  
Ilaria Barlocco ◽  
Sofia Capelli ◽  
Xiuyuan Lu ◽  
Simone Tumiati ◽  
Nikolaos Dimitratos ◽  
...  
Keyword(s):  
Density Functional Theory ◽  
Dft Calculations ◽  
Formic Acid ◽  
Active Sites ◽  
Density Functional ◽  
Carbon Materials ◽  
Functional Theory ◽  
Metal Free ◽  
Formic Acid Dehydrogenation

A combination of experiments and Density functional theory (DFT) calculations demonstrated that the single vacancies present on the graphitic layers are the only active sites for FA dehydrogenation.

Synthetic and Mechanistic Studies of a Versatile Heteroaryl Thioether Directing Group for Pd(II) Catalysis

2019 ◽  
Author(s):  
Andrew Romine ◽  
Kin Yang ◽  
Malkanthi Karunananda ◽  
Jason Chen ◽  
Keary Engle
Keyword(s):  
Mechanistic Studies ◽  
Salvianolic Acid ◽  
Wide Range ◽  
Computational Data ◽  
Synthetic Utility ◽  
Directing Group ◽  
High Yields ◽  
Julia Olefination ◽  
Reaction Progress Kinetic Analysis

A weakly coordinating monodentate heteroaryl thioether directing group has been developed for use in Pd(II) catalysis to orchestrate key elementary steps in the catalytic cycle that require conformational flexibility in a manner that is difficult to accomplish with traditional strongly coordinating directing groups. This benzothiazole thioether, (BT)S, directing group can be used to promote oxidative Heck reactivity of internal alkenes providing a wide range of products in moderate to high yields. To demonstrate the broad applicability of this directing group, arene C–H olefination was also successfully developed. Reaction progress kinetic analysis provides insights into the role of the directing group in each reaction, which is supplemented with computational data for the oxidative Heck reaction. Furthermore, this (BT)S directing group can be transformed into a number of synthetically useful functional groups, including a sulfone for Julia olefination, allowing it to serve as a “masked olefin” directing group in synthetic planning. In order to demonstrate this synthetic utility, natural products (+)-salvianolic acid A and salvianolic acid F are formally synthesized using the (BT)S directed C–H olefination as the key step.

scholarly journals Global phosphoproteomics reveals DYRK1A regulates CDK1 activity in glioblastoma cells

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Ariadna Recasens ◽  
Sean J. Humphrey ◽  
Michael Ellis ◽  
Monira Hoque ◽  
Ramzi H. Abbassi ◽  
...  
Keyword(s):  
Ubiquitin Ligase ◽  
Cyclin B ◽  
Anaphase Promoting Complex ◽  
Mechanistic Studies ◽  
Glioblastoma Cells ◽  
Cycle Arrest ◽  
Dual Specificity ◽  
Rb Pathway ◽  
High Doses

AbstractBoth tumour suppressive and oncogenic functions have been reported for dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). Herein, we performed a detailed investigation to delineate the role of DYRK1A in glioblastoma. Our phosphoproteomic and mechanistic studies show that DYRK1A induces degradation of cyclin B by phosphorylating CDC23, which is necessary for the function of the anaphase-promoting complex, a ubiquitin ligase that degrades mitotic proteins. DYRK1A inhibition leads to the accumulation of cyclin B and activation of CDK1. Importantly, we established that the phenotypic response of glioblastoma cells to DYRK1A inhibition depends on both retinoblastoma (RB) expression and the degree of residual DYRK1A activity. Moderate DYRK1A inhibition leads to moderate cyclin B accumulation, CDK1 activation and increased proliferation in RB-deficient cells. In RB-proficient cells, cyclin B/CDK1 activation in response to DYRK1A inhibition is neutralized by the RB pathway, resulting in an unchanged proliferation rate. In contrast, complete DYRK1A inhibition with high doses of inhibitors results in massive cyclin B accumulation, saturation of CDK1 activity and cell cycle arrest, regardless of RB status. These findings provide new insights into the complexity of context-dependent DYRK1A signalling in cancer cells.

Disclosing the role of Gold on Palladium ‐ Gold alloyed supported catalysts in formic acid decomposition

ChemCatChem ◽  
2021 ◽  
Author(s):  
Alberto Villa ◽  
Ilaria Barlocco ◽  
Sofia Capelli ◽  
Xiuyuan Lu ◽  
Silvio Bellomi ◽  
...  
Keyword(s):  
Formic Acid ◽  
Supported Catalysts ◽  
Acid Decomposition ◽  
Formic Acid Decomposition

scholarly journals Metal‐Free Deoxygenation of Amine N–Oxides: Synthetic and Mechanistic Studies

ChemPhysChem ◽  
2021 ◽  
Author(s):  
Sami Lakhdar ◽  
William Lecroq ◽  
Jules Schleinitz ◽  
Mallaury Billoue ◽  
Anna Perfetto ◽  
...  
Keyword(s):  
Mechanistic Studies ◽  
Metal Free

scholarly journals Selectivity Effects in Bimetallic Catalysis: Role of the Metal Sites in the Decomposition of Formic Acid into H2and CO2by the Coinage Metal Binuclear Complexes [dppmMM′(H)]+

ChemCatChem ◽  
2017 ◽  
Vol 9 (7) ◽  
pp. 1298-1302 ◽  
Author(s):  
Athanasios Zavras ◽  
Marjan Krstić ◽  
Philippe Dugourd ◽  
Vlasta Bonačić-Koutecký ◽  
Richard A. J. O'Hair
Keyword(s):  
Formic Acid ◽  
Binuclear Complexes ◽  
Coinage Metal ◽  
Bimetallic Catalysis

The Fe(III)-catalyzed functionalization of saturated hydrocarbons by tert-butyl hydroperoxide: Mechanistic studies on the role of dioxygen

1992 ◽  
Vol 33 (38) ◽  
pp. 5473-5476 ◽  
Author(s):  
Derek H.R. Barton ◽  
Stéphane D. Bévière ◽  
Warinthorn Chavasiri ◽  
Darío Doller ◽  
Bin Hu
Keyword(s):  
Mechanistic Studies ◽  
Saturated Hydrocarbons ◽  
Butyl Hydroperoxide ◽  
Tert Butyl ◽  
Tert Butyl Hydroperoxide
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