scholarly journals β-Glutamine-mediated self-association of transmembrane β-peptides within lipid bilayers

2016 ◽  
Vol 7 (9) ◽  
pp. 5900-5907 ◽  
Author(s):  
U. Rost ◽  
C. Steinem ◽  
U. Diederichsen
Keyword(s):  
Hydrogen Bonds ◽  
Lipid Bilayers ◽  
Rational Design ◽  
Secondary Structures ◽  
Design And Synthesis ◽  
Self Association

The rational design and synthesis of novel transmembrane β-peptides forming stable secondary structures in a membrane environment are described. Their state of aggregation within the membrane is controlled by hydrogen bonds.

scholarly journals Rational Design and Synthesis of Right-Handed d-Sulfono-γ-AApeptide Helical Foldamers as Potent Inhibitors of Protein–Protein Interactions

2020 ◽  
Vol 85 (16) ◽  
pp. 10552-10560
Author(s):  
Peng Sang ◽  
Yan Shi ◽  
Pirada Higbee ◽  
Minghui Wang ◽  
Sami Abdulkadir ◽  
...  
Keyword(s):  
Protein Interactions ◽  
Rational Design ◽  
Protein Protein Interactions ◽  
Design And Synthesis

Rational design and synthesis of novel Syk-kinase inhibitors

2012 ◽  
Vol 22 (2) ◽  
pp. 73-74 ◽  
Author(s):  
Alexey A. Zeifman ◽  
Ilya Yu. Titov ◽  
Igor V. Svitanko ◽  
Tatiana V. Rakitina ◽  
Aleksey V. Lipkin ◽  
...  
Keyword(s):  
Rational Design ◽  
Kinase Inhibitors ◽  
Design And Synthesis ◽  
Syk Kinase

Rational design and synthesis of multimorphology mesoporous carbon@silica nanoparticles with tailored structure

Carbon ◽  
2021 ◽  
Author(s):  
Yajuan Zhao ◽  
Haolin Lyu ◽  
Yujie Liu ◽  
Wenjie Liu ◽  
Yong Tian ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Mesoporous Carbon ◽  
Rational Design ◽  
Design And Synthesis

scholarly journals Rational Design and Synthesis of a Novel Anti-leukemic Agent Targeting Bruton′s Tyrosine Kinase (BTK), LFM-A13 [α-Cyano-β-Hydroxy-β-Methyl-N-(2,5-Dibromophenyl)Propenamide]

1999 ◽  
Vol 274 (14) ◽  
pp. 9587-9599 ◽  
Author(s):  
Sandeep Mahajan ◽  
Sutapa Ghosh ◽  
Elise A. Sudbeck ◽  
Yaguo Zheng ◽  
Suzanne Downs ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Rational Design ◽  
Design And Synthesis

3D hierarchically mesoporous Cu-doped NiO nanostructures as high-performance anode materials for lithium ion batteries

CrystEngComm ◽  
2015 ◽  
Vol 17 (48) ◽  
pp. 9336-9347 ◽  
Author(s):  
Jingyun Ma ◽  
Longwei Yin ◽  
Tairu Ge
Keyword(s):  
Porous Structure ◽  
Lithium Ion Batteries ◽  
Surface Area ◽  
Anode Materials ◽  
High Performance ◽  
Rational Design ◽  
Three Dimensional ◽  
Lithium Ion ◽  
Design And Synthesis ◽  
Hierarchically Porous Structure

We report on the rational design and synthesis of three dimensional (3D) Cu-doped NiO architectures with an adjustable chemical component, surface area, and hierarchically porous structure as anodes for lithium ion battery.

Rational design of a pyrene based luminescent porous supramolecular framework: excimer emission and energy transfer

RSC Advances ◽  
2015 ◽  
Vol 5 (92) ◽  
pp. 74986-74993 ◽  
Author(s):  
Komal Prasad ◽  
Ritesh Haldar ◽  
Tapas Kumar Maji
Keyword(s):  
Energy Transfer ◽  
Rational Design ◽  
Light Harvesting ◽  
Supramolecular Framework ◽  
Excimer Emission ◽  
Design And Synthesis ◽  
Porous Framework ◽  
Synthesis Approach

Based on rational design and synthesis approach, a pyrene based supramolecular flexible porous framework of Zn(ii) has been synthesized. It shows excimer emission and has been exploited for light harvesting application.

Syntheses, structures and characterization of isomorphous CoII and NiII coordination polymers based on 2-[(1H-imidazol-1-yl)methyl]-6-methyl-1H-benzimidazole and benzene-1,4-dicarboxylate

2017 ◽  
Vol 73 (8) ◽  
pp. 645-651 ◽  
Author(s):  
Qiu-Ying Huang ◽  
Yang Zhao ◽  
Xiang-Ru Meng
Keyword(s):  
Coordination Polymers ◽  
Rational Design ◽  
Three Dimensional ◽  
Spectroscopic Properties ◽  
Polymeric Chain ◽  
Design And Synthesis ◽  
Carboxylate Groups ◽  
Metal Organic ◽  
The One ◽  
Ir Spectroscopic

Careful choice of the organic ligands is one of the most important parameters in the rational design and synthesis of coordination polymers. Aromatic polycarboxylates have been widely used in the preparation of metal–organic polymers since they can utilize various coordination modes to form diverse structures and can act as hydrogen-bond acceptors and donors in the assembly of supramolecular structures. Nitrogen-heterocyclic organic compounds have also been used extensively as ligands for the construction of polymers with interesting structures. In the polymers catena-poly[[[diaquabis{2-[(1H-imidazol-1-yl)methyl]-6-methyl-1H-benzimidazole-κN 3}cobalt(II)]-μ2-benzene-1,4-dicarboxylato-κ2 O 1:O 4] dihydrate], {[Co(C8H4O4)(C12H11N4)2(H2O)2]·2H2O} n , (I), and catena-poly[[[diaquabis{2-[(1H-imidazol-1-yl)methyl]-6-methyl-1H-benzimidazole-κN 3}nickel(II)]-μ2-benzene-1,4-dicarboxylato-κ2 O 1:O 4] dihydrate], {[Ni(C8H4O4)(C12H11N4)2(H2O)2]·2H2O} n , (II), the CoII or NiII ion lies on an inversion centre and exhibits a slightly distorted octahedral coordination geometry, coordinated by two N atoms from two imidazole rings and four O atoms from two monodentate carboxylate groups and two water molecules. The dicarboxylate ligands bridge metal ions forming a polymeric chain. The 2-[(1H-imidazol-1-yl)methyl]-6-methyl-1H-benzimidazole ligands coordinate to the CoII or NiII centres in monodentate modes through an imidazole N atom and are pendant on opposite sides of the main chain. The two structures are isomorphous. In the crystal, the one-dimensional chains are further connected through O—H...O, O—H...N and N—H...O hydrogen bonds, leading to a three-dimensional supramolecular architecture. In addition, the IR spectroscopic properties, PXRD patterns, thermogravimetric behaviours and fluorescence properties of both polymers have been investigated.

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