scholarly journals Pyroglutamate aminopeptidase 1 may be an indicator of cellular inflammatory response as revealed using a sensitive long-wavelength fluorescent probe

2016 ◽  
Vol 7 (7) ◽  
pp. 4694-4697 ◽  
Author(s):  
Qiuyu Gong ◽  
Lihong Li ◽  
Xiaofeng Wu ◽  
Huimin Ma
Keyword(s):  
Inflammatory Response ◽  
Fluorescent Probe ◽  
Long Wavelength ◽  
Cellular Inflammatory Response

The cellular inflammatory response in nicotinate skin reactions

1987 ◽  
Vol 116 (3) ◽  
pp. 341-349 ◽  
Author(s):  
J.S.C. ENGLISH ◽  
R.K. WINKELMANN ◽  
J.B. LOUBACK ◽  
M.W. GREAVES ◽  
D.M. MACDONALD
Keyword(s):  
Inflammatory Response ◽  
Skin Reactions ◽  
Cellular Inflammatory Response

Docosahexaenoic acid reduces cellular inflammatory response following permanent focal cerebral ischemia in rats

2013 ◽  
Vol 24 (12) ◽  
pp. 2127-2137 ◽  
Author(s):  
Cheng-Yi Chang ◽  
Yu-Hsiang Kuan ◽  
Jian-Ri Li ◽  
Wen-Ying Chen ◽  
Yen-Chuan Ou ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Docosahexaenoic Acid ◽  
Inflammatory Response ◽  
Focal Cerebral Ischemia ◽  
Cellular Inflammatory Response

Oxidative stress and inflammation contribute to lung toxicity after a common breast cancer chemotherapy regimen

2002 ◽  
Vol 283 (2) ◽  
pp. L336-L345 ◽  
Author(s):  
Amir M. Abushamaa ◽  
Thomas A. Sporn ◽  
Rodney J. Folz
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Lung Injury ◽  
Inflammatory Response ◽  
Chemotherapeutic Agents ◽  
Total Cell ◽  
Lung Toxicity ◽  
High Dose ◽  
Cell Counts ◽  
Cellular Inflammatory Response

Delayed pulmonary toxicity syndrome after high-dose chemotherapy (HDC) and autologous hematopoietic support occurs in up to 64% of women with advanced-stage breast cancer. Using a similar, but nonmyeloablative, HDC treatment regimen in mice, we found both immediate and persistent lung injury, coincident with marked decreases in lung tissue glutathione reductase activity and accompanied by increases in lung oxidized glutathione, bronchoalveolar lavage (BAL) lipid peroxidation, and BAL total cell counts. Most interestingly, at 6 wk, BAL total cell counts had increased fourfold, with lymphocyte cell counts increasing >11-fold. A single supplemental dose of glutathione prevented early lung injury at 48 h but showed no lung-protective effects at 6 wk, whereas single doses of other thiol-sparing agents (Ethyol and glutathione monoethyl ester) showed no benefit. These data suggest that this HDC regimen results in acute and persistent lung toxicity, induced in part by oxidative stress, that culminates with an acute lung cellular inflammatory response. Continuous glutathione supplementation and/or attenuation of the delayed pulmonary inflammatory response may prove beneficial in preventing lung toxicity after the use of these chemotherapeutic agents.

A long-wavelength fluorescent probe for amino compounds and its application in the determination of aliphatic amines

2018 ◽  
Vol 10 (26) ◽  
pp. 3188-3196
Author(s):  
Li-Jun Xia ◽  
Xiao-Feng Guo ◽  
Yan Ji ◽  
Liu Chen ◽  
Hong Wang
Keyword(s):  
Fluorescent Probe ◽  
Fluorescence Detection ◽  
Detection Method ◽  
Aliphatic Amines ◽  
Long Wavelength ◽  
Amino Compounds

In this study, a simple HPLC-fluorescence detection method for aliphatic amines was developed with a novel long-wavelength BODIPY-based derivatization reagent.

scholarly journals Long Wavelength TCF-Based Fluorescent Probe for the Detection of Alkaline Phosphatase in Live Cells

2019 ◽  
Vol 7 ◽  
Author(s):  
Lauren Gwynne ◽  
Adam C. Sedgwick ◽  
Jordan E. Gardiner ◽  
George T. Williams ◽  
Gyoungmi Kim ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Fluorescent Probe ◽  
Live Cells ◽  
Long Wavelength

The development of a hemicyanine-based ratiometric CO fluorescent probe with a long emission wavelength and its applications for imaging CO in vitro and in vivo

2020 ◽  
Vol 44 (28) ◽  
pp. 12107-12112 ◽  
Author(s):  
Yunyan Zhang ◽  
Xiuqi Kong ◽  
Yonghe Tang ◽  
Min Li ◽  
Yaguang Yin ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Living Cells ◽  
Emission Wavelength ◽  
Long Wavelength ◽  
Wavelength Emission ◽  
Ratiometric Fluorescent Probe

A novel ratiometric fluorescent probe, Hcy-CO, with long-wavelength emission was developed for visualizing CO in living cells and zebrafish.

scholarly journals Resveratrol Inhibits Particulate Matter-Induced Inflammatory Responses in Human Keratinocytes

2020 ◽  
Vol 21 (10) ◽  
pp. 3446 ◽  
Author(s):  
Jung-Won Shin ◽  
Hyun-Sun Lee ◽  
Jung-Im Na ◽  
Chang-Hun Huh ◽  
Kyung-Chan Park ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Inflammatory Response ◽  
Molecular Mechanisms ◽  
Inflammatory Responses ◽  
Antioxidant Properties ◽  
Complex Mixture ◽  
Human Keratinocytes ◽  
Receptor Activation ◽  
Air Pollutant ◽  
Cellular Inflammatory Response

Particulate matter (PM), a major air pollutant, is a complex mixture of solid and liquid particles of various sizes. PM has been demonstrated to cause intracellular inflammation in human keratinocytes, and is associated with various skin disorders, including atopic dermatitis, eczema, and skin aging. Resveratrol is a natural polyphenol with strong antioxidant properties, and its beneficial effects against skin changes due to PM remain elusive. Therefore, in the present study, we investigated the effect of resveratrol on PM-induced skin inflammation and attempted to deduce the molecular mechanisms underlying resveratrol’s effects. We found that resveratrol inhibited PM-induced aryl hydrocarbon receptor activation and reactive oxygen species formation in keratinocytes. It also suppressed the subsequent cellular inflammatory response by inhibiting mitogen-activated protein kinase activation. Consequentially, resveratrol reduced PM-induced cyclooxygenase-2/prostaglandin E2 and proinflammatory cytokine expression, including that of matrix metalloproteinase (MMP)-1, MMP-9, and interleukin-8, all of which are known to be central mediators of various inflammatory conditions and aging. In conclusion, resveratrol inhibits the PM-induced inflammatory response in human keratinocytes, and we suggest that resveratrol may have potential for preventing air pollution-related skin problems.

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