scholarly journals Polymeric vector-mediated delivery of an miR-21 inhibitor for prostate cancer treatment

RSC Advances ◽  
2017 ◽  
Vol 7 (18) ◽  
pp. 11057-11066 ◽  
Author(s):  
Chuyi Chen ◽  
Xinghua Huang ◽  
Yong Wang ◽  
Liteng Lin ◽  
Lei Liu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Treatment ◽  
Effective Treatment ◽  
Delivery System ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Treatment

An miR-21 silencing strategy based on a polymeric vector-mediated delivery system was developed for the effective treatment of human prostate cancer.

scholarly journals Bauhinia purprea agglutinin ‐modified liposomes for human prostate cancer treatment

2015 ◽  
Vol 107 (1) ◽  
pp. 53-59 ◽  
Author(s):  
Keisuke Ikemoto ◽  
Kosuke Shimizu ◽  
Kento Ohashi ◽  
Yoshihito Takeuchi ◽  
Motohiro Shimizu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Treatment ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Prostate Cancer Treatment

Methylglyoxal–Induced Apoptosis in Human Prostate Carcinoma: Potential Modality for Prostate Cancer Treatment

2000 ◽  
Vol 37 (6) ◽  
pp. 728-734 ◽  
Author(s):  
Dan M. Milanesa ◽  
Muhammad S. Choudhury ◽  
Camille Mallouh ◽  
Hiroshi Tazaki ◽  
Sensuke Konno
Keyword(s):  
Prostate Cancer ◽  
Cancer Treatment ◽  
Prostate Carcinoma ◽  
Human Prostate ◽  
Prostate Cancer Treatment ◽  
Human Prostate Carcinoma ◽  
Induced Apoptosis

scholarly journals TLE3 loss confers AR inhibitor resistance by facilitating GR-mediated human prostate cancer cell growth

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Sander AL Palit ◽  
Daniel Vis ◽  
Suzan Stelloo ◽  
Cor Lieftink ◽  
Stefan Prekovic ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Lncap Cells ◽  
Cancer Cell Growth ◽  
Prostate Cancer Treatment ◽  
Human Prostate Cancer Cell ◽  
Genome Wide ◽  
A Genome ◽  
Inhibitor Resistance

Androgen receptor (AR) inhibitors represent the mainstay of prostate cancer treatment. In a genome-wide CRISPR-Cas9 screen using LNCaP prostate cancer cells, loss of co-repressor TLE3 conferred resistance to AR antagonists apalutamide and enzalutamide. Genes differentially expressed upon TLE3 loss share AR as the top transcriptional regulator, and TLE3 loss rescued the expression of a subset of androgen-responsive genes upon enzalutamide treatment. GR expression was strongly upregulated upon AR inhibition in a TLE3-negative background. This was consistent with binding of TLE3 and AR at the GR locus. Furthermore, GR binding was observed proximal to TLE3/AR-shared genes. GR inhibition resensitized TLE3KO cells to enzalutamide. Analyses of patient samples revealed an association between TLE3 and GR levels that reflected our findings in LNCaP cells, of which the clinical relevance is yet to be determined. Together, our findings reveal a mechanistic link between TLE3 and GR-mediated resistance to AR inhibitors in human prostate cancer.

629: Novel Laser Activated Gold Nanoshell Thermal Ablation of Human Prostate Cancer in Vivo

2007 ◽  
Vol 177 (4S) ◽  
pp. 210-211 ◽  
Author(s):  
Joshua M. Stern ◽  
Jennifer Stanfield ◽  
Jer-Tsang Hsieh ◽  
Jeffrey A. Cadeddu
Keyword(s):  
Prostate Cancer ◽  
Thermal Ablation ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Gold Nanoshell

1495: Elevated Expression of Tumor-Associated Macrophages is Associated with Poor Prognosis of Human Prostate Cancer

2006 ◽  
Vol 175 (4S) ◽  
pp. 483-483
Author(s):  
Hitoshi Takayama ◽  
Norio Nonomura ◽  
Daizo Oka ◽  
Masahiro Shiba ◽  
Yasuyuki Arai ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Poor Prognosis ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Tumor Associated Macrophages ◽  
Elevated Expression

797: Noggin Blocks the Osteoinductive Properties of Human Prostate Cancer Cell Lines

2006 ◽  
Vol 175 (4S) ◽  
pp. 258-258
Author(s):  
Ruth Schwaninger ◽  
Cyrill A. Rentsch ◽  
Antoinette Wetterwald ◽  
Irena Klima ◽  
Gabri Van der Pluijm ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Lines ◽  
Human Prostate ◽  
Human Prostate Cancer ◽  
Human Prostate Cancer Cell ◽  
Prostate Cancer Cell Lines

1077: A Novel Apoptosis-Inducing Gene and its Application in Prostate Cancer Treatment

2004 ◽  
Vol 171 (4S) ◽  
pp. 284-284
Author(s):  
Yi Lu ◽  
Jun Zhang ◽  
Ben Beheshti ◽  
Ximing J. Yang ◽  
Syamal K. Bhattacharya ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Treatment ◽  
Prostate Cancer Treatment
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