scholarly journals A practical iodine-catalyzed oxidative conversion of aldehydes to nitriles

RSC Advances ◽  
2017 ◽  
Vol 7 (3) ◽  
pp. 1484-1489 ◽  
Author(s):  
Chaojie Fang ◽  
Meichao Li ◽  
Xinquan Hu ◽  
Weimin Mo ◽  
Baoxiang Hu ◽  
...  
Keyword(s):  
Nitrogen Source ◽  
Efficient Method ◽  
Ammonium Acetate ◽  
Direct Synthesis ◽  
Oxidative Conversion ◽  
Butyl Hydroperoxide

A simple and efficient method for the direct synthesis of nitriles from aldehydes using ammonium acetate as the nitrogen source, iodine as the catalyst, and tert-butyl hydroperoxide (TBHP) as the oxidant was developed.

A novel and efficient method for the direct synthesis of pyrrolyl or indolyl substituted 9,10-dihydrophenanthren-9-ol analogues

2020 ◽  
Vol 61 (7) ◽  
pp. 151500
Author(s):  
Qi Xia ◽  
Xinlei Zhao ◽  
Juan Zhang ◽  
Jiayi Wang ◽  
Gonghua Song
Keyword(s):  
Efficient Method ◽  
Direct Synthesis

Direct synthesis of sulfonated dihydroisoquinolinones from N-allylbenzamide and arylsulfinic acids via TBHP-promoted cascade radical addition and cyclization

2016 ◽  
Vol 52 (77) ◽  
pp. 11559-11562 ◽  
Author(s):  
Dong Xia ◽  
Yang Li ◽  
Tao Miao ◽  
Pinhua Li ◽  
Lei Wang
Keyword(s):  
Direct Synthesis ◽  
Radical Addition ◽  
Butyl Hydroperoxide

A novel tert-butyl hydroperoxide (TBHP)-promoted cascade radical addition and cyclization of N-allylbenzamides and arylsulfinic acids to sulfonated dihydroisoquinolinones was developed.

scholarly journals K7Na3P2W18Cu4O68: A Mild, Efficient, and Reusable Catalyst for the One-Pot Synthesis of 1,2,4,5-Tetra Substituted Imidazoles

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Nasim Milani Kalkhorani ◽  
Majid M. Heravi
Keyword(s):  
Efficient Method ◽  
Ammonium Acetate ◽  
Solvent Free ◽  
Reusable Catalyst ◽  
One Pot ◽  
One Pot Synthesis ◽  
Solvent Free Conditions ◽  
The One

An efficient method for the synthesis of 1,2,4,5-tetra substituted imidazoles usingK7Na3P2W18Cu4O68as catalyst is reported. This four-component condensation of benzil, aldehydes, amines, and ammonium acetate proceeds under solvent-free conditions. The catalyst is handling and recoverable.

scholarly journals Direct synthesis of amides from nonactivated carboxylic acids using urea as nitrogen source and Mg(NO3)2 or imidazole as catalysts

2020 ◽  
Vol 11 (22) ◽  
pp. 5808-5818 ◽  
Author(s):  
A. Rosie Chhatwal ◽  
Helen V. Lomax ◽  
A. John Blacker ◽  
Jonathan M. J. Williams ◽  
Patricia Marcé
Keyword(s):  
Nitrogen Source ◽  
Carboxylic Acids ◽  
Direct Synthesis

This methodology is particularly useful for the direct synthesis of primary and N-methyl amides using urea as a stable and easy to manipulate nitrogen source.

scholarly journals Synthesis of Nitroaromatic Compounds via Three-Component Ring Transformations

Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 639
Author(s):  
Song Thi Le ◽  
Haruyasu Asahara ◽  
Nagatoshi Nishiwaki
Keyword(s):  
Nitrogen Source ◽  
Ammonium Acetate ◽  
Nitroaromatic Compounds ◽  
Ring Transformation ◽  
Leaving Group ◽  
Ring Transformations ◽  
Alternative Procedures ◽  
Synthetic Equivalent ◽  
Electron Deficiency

1-Methyl-3,5-dinitro-2-pyridone serves as an excellent substrate for nucleophilic-type ring transformation because of the electron deficiency and presence of a good leaving group. In this review, we focus on the three-component ring transformation (TCRT) of dinitropyridone involving a ketone and a nitrogen source. When dinitropyridone is allowed to react with a ketone in the presence of ammonia, TCRT proceeds to afford nitropyridines that are not easily produced by alternative procedures. Ammonium acetate can be used as a nitrogen source instead of ammonia to undergo the TCRT, leading to nitroanilines in addition to nitropyridines. In these reactions, dinitropyridone serves as a safe synthetic equivalent of unstable nitromalonaldehyde.

scholarly journals An Efficient Method for The Synthesis of Dihydropyridine by Hantzsch Reaction with Fe/SiO2 Nano Heterogeneous Catalysts

2020 ◽  
Vol 15 (3) ◽  
pp. 617-630
Author(s):  
Ateeq Rahman ◽  
P. N. Nehemia ◽  
Moola M. Nyambe
Keyword(s):  
Efficient Method ◽  
Room Temperature ◽  
Heterogeneous Catalysts ◽  
Ammonium Acetate ◽  
Gas Chromatography Mass Spectrometry ◽  
Impregnation Method ◽  
Hantzsch Reaction ◽  
Melting Points ◽  
Title Reaction ◽  
Layer Chromatography

An efficient method for the synthesis of dihydropyridines (DHPs) by Hantzsch reaction with Fe/SiO2 heterogeneous catalysts was developed. The Fe/SiO2 catalysts was prepared by impregnation method. The catalysts were characterized by IR and SEM instruments. The SEM results indicated that Fe/SiO2 nano spheres were formed. The reaction procedure involved reaction of aldehyde, ethyl acetoacetate (EAA), ammonium acetate (NH4OAc) and ethanol under reflux. The study was focused on optimizing reactions conditions: Standardization of catalyst, substrate of study and solvent study. In order to identify the best active catalysts, five different ratios of catalyst were synthesized and evaluated for the title reaction under similar conditions. To standardize the active catalysts, different temperature conditions (i.e. room temperature, 60 ºC and 80 ºC) as well as catalysts amounts were evaluated. Under these established conditions, 2.5% Fe/SiO2 was the best active catalysts that resulted. Benzaldehyde and p-anisaldehyde were used to study the effect of having various substrates on the conversion and reaction time, especially the substituted aldehydes. The best results were obtained by reacting p-anisaldehyde with EAA, NH4OAc and ethanol at 60 ºC with 0.3 grams of 2.5% Fe/SiO2 heterogeneous catalysts. Thin Layer Chromatography (TLC) monitoring of the reaction mixture showed no selectivity at high temperatures (80 ºC) with 15% Fe/SiO2. Standardization of solvent study was executed with two solvents, ethanol and acetonitrile. The product dihydropyridines were analyzed using gas chromatography-mass spectrometry (GC-MS). The melting points of the products were compared with authentic samples reported in the literature. Hence, the Fe/SiO2 catalysts is eco-friendly and economically developed for the title reaction. Copyright © 2020 BCREC Group. All rights reserved 

ChemInform Abstract: Direct Synthesis of Nitriles from Cleavage of C=C Double Bond with Nitrite as the Nitrogen Source and Oxidant.

ChemInform ◽  
2016 ◽  
Vol 47 (40) ◽  
Author(s):  
Qiang Liu ◽  
Bao Fang ◽  
Xiaohui Bai ◽  
Yuan Liu ◽  
Yao Wu ◽  
...  
Keyword(s):  
Double Bond ◽  
Nitrogen Source ◽  
Direct Synthesis
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