scholarly journals Reduction of neuronal damage and promotion of locomotor recovery after spinal cord injury by early administration of methylprednisolone: possible involvement of autophagy pathway

RSC Advances ◽  
2017 ◽  
Vol 7 (5) ◽  
pp. 2979-2991 ◽  
Author(s):  
Yichao Jin ◽  
Shaofeng Yang ◽  
Xiaohua Zhang
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neuronal Damage ◽  
Neuroprotective Effect ◽  
Early Administration ◽  
Locomotor Recovery ◽  
Cord Injury ◽  
Autophagy Pathway

Interaction between autophagy and apoptosis participates in the neuroprotective effect of methylprednisolone on spinal cord injury.

Autophagy Reduces Neuronal Damage and Promotes Locomotor Recovery via Inhibition of Apoptosis After Spinal Cord Injury in Rats

2013 ◽  
Vol 49 (1) ◽  
pp. 276-287 ◽  
Author(s):  
Peifu Tang ◽  
Hongping Hou ◽  
Licheng Zhang ◽  
Xia Lan ◽  
Zhi Mao ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neuronal Damage ◽  
Locomotor Recovery ◽  
Cord Injury

scholarly journals Erratum to: Autophagy Reduces Neuronal Damage and Promotes Locomotor Recovery via Inhibition of Apoptosis after Spinal Cord Injury in Rats

2013 ◽  
Vol 49 (1) ◽  
pp. 288-289 ◽  
Author(s):  
Peifu Tang ◽  
Hongping Hou ◽  
Licheng Zhang ◽  
Xia Lan ◽  
Zhi Mao ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neuronal Damage ◽  
Locomotor Recovery ◽  
Cord Injury

Neuroprotective Effect of Epidural Electrical Stimulation against Ischemic Spinal Cord Injury in Rats

2005 ◽  
Vol 103 (1) ◽  
pp. 84-92 ◽  
Author(s):  
Manabu Kakinohana ◽  
Hideki Harada ◽  
Yasunori Mishima ◽  
Tatsuhiko Kano ◽  
Kazuhiro Sugahara
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Electrical Stimulation ◽  
Neuroprotective Effect ◽  
Spinal Cord Ischemia ◽  
Aortic Occlusion ◽  
Cord Injury ◽  
Optimal Setting ◽  
Transient Aortic Occlusion ◽  
Ischemic Spinal Cord Injury

Background Electroconvulsion therapy is likely to serve as an effective preconditioning stimulus for inducing tolerance to ischemic brain injury. The current study examines whether electrical stimuli on the spinal cord is also capable of inducing tolerance to ischemic spinal cord injury by transient aortic occlusion. Methods Spinal cord ischemia was induced by occlusion of the descending thoracic aorta in combination with maintaining systemic hypotension (40 mmHg) during the procedure. Animals implanted with epidural electrodes were divided into four groups according to electrical stimulation and sham. Two groups consisted of rapid preconditioning (RE group, n = 8) and sham procedure (RC group, n = 8) 30 min before 9 min of spinal cord ischemia. In the two groups that underwent delayed preconditioning, rats were exposed to 9 min of aortic occlusion 24 h after either pretreatment with epidural electrical stimulation (DE group, n = 8) or sham (DC group, n = 8). In addition, rats were exposed to 6-11 min of spinal cord ischemia at 30 min or 24 h after epidural electrical stimulation or sham stimulation. The group P50 represents the duration of spinal cord ischemia associated with 50% probability of resultant paraplegia. Results Pretreatment with electrical stimulation in the DE group but not the RE group protected the spinal cord against ischemia, and this stimulation prolonged the P50 by approximately 15.0% in the DE group compared with the DC group. Conclusions Although the optimal setting for this electrical preconditioning should be determined in future studies, the results suggest that epidural electrical stimulation will be a useful approach to provide spinal protection against ischemia.

Augmented Locomotor Recovery after Spinal Cord Injury in the Athymic Nude Rat

2006 ◽  
Vol 23 (5) ◽  
pp. 660-673 ◽  
Author(s):  
Jason R. Potas ◽  
Yu Zheng ◽  
Charbel Moussa ◽  
Melinda Venn ◽  
Catherine A. Gorrie ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Locomotor Recovery ◽  
Nude Rat ◽  
Cord Injury

scholarly journals Function of the nucleus accumbens in motor control during recovery after spinal cord injury

Science ◽  
2015 ◽  
Vol 350 (6256) ◽  
pp. 98-101 ◽  
Author(s):  
Masahiro Sawada ◽  
Kenji Kato ◽  
Takeharu Kunieda ◽  
Nobuhiro Mikuni ◽  
Susumu Miyamoto ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Nucleus Accumbens ◽  
High Frequency ◽  
Neuronal Damage ◽  
Recovery Period ◽  
Oscillatory Activity ◽  
Finger Movements ◽  
Early Recovery ◽  
Cord Injury

Motivation facilitates recovery after neuronal damage, but its mechanism is elusive. It is generally thought that the nucleus accumbens (NAc) regulates motivation-driven effort but is not involved in the direct control of movement. Using causality analysis, we identified the flow of activity from the NAc to the sensorimotor cortex (SMC) during the recovery of dexterous finger movements after spinal cord injury at the cervical level in macaque monkeys. Furthermore, reversible pharmacological inactivation of the NAc during the early recovery period diminished high-frequency oscillatory activity in the SMC, which was accompanied by a transient deficit of amelioration in finger dexterity obtained by rehabilitation. These results demonstrate that during recovery after spinal damage, the NAc up-regulates the high-frequency activity of the SMC and is directly involved in the control of finger movements.

Epidural electrical stimulation to facilitate locomotor recovery after spinal cord injury

2021 ◽  
Author(s):  
Johannie Audet ◽  
Charly G. Lecomte
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Electrical Stimulation ◽  
Clinical Implementation ◽  
Preclinical Models ◽  
Lumbosacral Region ◽  
Locomotor Recovery ◽  
Promising Therapeutic Approach ◽  
Cord Injury ◽  
Stimulation Of

Tonic or phasic electrical epidural stimulation of the lumbosacral region of the spinal cord facilitates locomotion and standing in a variety of preclinical models with severe spinal cord injury. However, the mechanisms of epidural electrical stimulation that facilitate sensorimotor functions remain largely unknown. This review aims to address how epidural electrical stimulation interacts with spinal sensorimotor circuits and discusses the limitations that currently restrict the clinical implementation of this promising therapeutic approach.

Lack of adenylate cyclase 1 (AC1): Consequences on corticospinal tract development and on locomotor recovery after spinal cord injury

2014 ◽  
Vol 1549 ◽  
pp. 1-10 ◽  
Author(s):  
H. Nait Taleb Ali ◽  
M.P. Morel ◽  
M. Doulazmi ◽  
S. Scotto-Lomassese ◽  
P. Gaspar ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Adenylate Cyclase ◽  
Corticospinal Tract ◽  
Locomotor Recovery ◽  
Cord Injury

Neuroprotective Effect of Vaccination with Autoantigen-Pulsed Dendritic Cells After Spinal Cord Injury

2012 ◽  
Vol 176 (1) ◽  
pp. 281-292 ◽  
Author(s):  
Yufu Wang ◽  
Ke Wang ◽  
Rui Chao ◽  
Jing Li ◽  
Lei Zhou ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Dendritic Cells ◽  
Neuroprotective Effect ◽  
Cord Injury

scholarly journals Oscillating field stimulation promotes axon regeneration and locomotor recovery after spinal cord injury

2022 ◽  
Vol 17 (6) ◽  
pp. 1318
Author(s):  
Jin-Zhu Bai ◽  
Yi-Xin Wang ◽  
Zhen Lyu ◽  
Guang-Hao Zhang ◽  
Xiao-Lin Huo
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Axon Regeneration ◽  
Field Stimulation ◽  
Locomotor Recovery ◽  
Cord Injury
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