scholarly journals Dietary supplementation of Thai black rice bran extract and yeast beta-glucan protects the dextran sodium sulphate mediated colitis induced rat

RSC Advances ◽  
2017 ◽  
Vol 7 (1) ◽  
pp. 396-402 ◽  
Author(s):  
Noppawat Pengkumsri ◽  
Bhagavathi Sundaram Sivamaruthi ◽  
Sasithorn Sirilun ◽  
Prasit Suwannalert ◽  
Teerapat Rodboon ◽  
...  

The present study was employed to evaluate the impact of black rice bran (RB) extract, and yeast β-glucan (YBG) supplementation on a dextran sodium sulfate (DSS)-induced colitis rat model.

2015 ◽  
Vol 6 (6) ◽  
pp. 419-433
Author(s):  
M. El - Bana ◽  
M. El - Sayed ◽  
Sahar AbdEl- Hady

2021 ◽  
Vol 22 (2) ◽  
pp. 772
Author(s):  
Javier Conde ◽  
Marlene Schwarzfischer ◽  
Egle Katkeviciute ◽  
Janine Häfliger ◽  
Anna Niechcial ◽  
...  

Environmental and genetic factors have been demonstrated to contribute to the development of inflammatory bowel disease (IBD). Recent studies suggested that the food additive; titanium dioxide (TiO2) might play a causative role in the disease. Therefore, in the present study we aimed to explore the interaction between the food additive TiO2 and the well-characterized IBD risk gene protein tyrosine phosphatase non-receptor type 2 (Ptpn2) and their role in the development of intestinal inflammation. Dextran sodium sulphate (DSS)-induced acute colitis was performed in mice lacking the expression of Ptpn2 in myeloid cells (Ptpn2LysMCre) or their wild type littermates (Ptpn2fl/fl) and exposed to the microparticle TiO2. The impact of Ptpn2 on TiO2 signalling pathways and TiO2-induced IL-1β and IL-10 levels were studied using bone marrow-derived macrophages (BMDMs). Ptpn2LysMCre exposed to TiO2 exhibited more severe intestinal inflammation than their wild type counterparts. This effect was likely due to the impact of TiO2 on the differentiation of intestinal macrophages, suppressing the number of anti-inflammatory macrophages in Ptpn2 deficient mice. Moreover, we also found that TiO2 was able to induce the secretion of IL-1β via mitogen-activated proteins kinases (MAPKs) and to repress the expression of IL-10 in bone marrow-derived macrophages via MAPK-independent pathways. This is the first evidence of the cooperation between the genetic risk factor Ptpn2 and the environmental factor TiO2 in the regulation of intestinal inflammation. The results presented here suggest that the ingestion of certain industrial compounds should be taken into account, especially in individuals with increased genetic risk


LWT ◽  
2007 ◽  
Vol 40 (10) ◽  
pp. 1732-1740 ◽  
Author(s):  
Jintana Wiboonsirikul ◽  
Shigeru Hata ◽  
Takuo Tsuno ◽  
Yukitaka Kimura ◽  
Shuji Adachi

2011 ◽  
Vol 24 (3) ◽  
pp. 273-281 ◽  
Author(s):  
Dong-Ju Kim ◽  
Su-Noh Ryu ◽  
Sang-Jun Han ◽  
Hwa-Young Kim ◽  
Jung-Hak Kim ◽  
...  

2016 ◽  
Vol 15 (9) ◽  
pp. 837-845 ◽  
Author(s):  
Enny Purwati Nurlaili ◽  
Mary Astuti ◽  
Yustinus Marsono ◽  
Sri Naruki

Author(s):  
N M Wartini ◽  
L P Wrasiati ◽  
I A A Widnyani ◽  
G P G Putra ◽  
I M A S Wijaya

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