scholarly journals Substituted 4-oxo-crotonic acid derivatives as a new class of protein kinase B (PknB) inhibitors: synthesis and SAR study

RSC Advances ◽  
2017 ◽  
Vol 7 (8) ◽  
pp. 4763-4775 ◽  
Author(s):  
Changliang Xu ◽  
Xiaoguang Bai ◽  
Jian Xu ◽  
Jinfeng Ren ◽  
Yun Xing ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase B ◽  
Structure Activity Relationship ◽  
Crotonic Acid ◽  
Activity Relationship ◽  
New Class ◽  
Structure Activity ◽  
Sar Study

Structure–activity relationship (SAR) study of a series of unsaturated crotonic acid derivatives as potential PknB inhibitors.

A mode of action study of cationic anthraquinone analogs: a new class of highly potent anticancer agents

MedChemComm ◽  
2015 ◽  
Vol 6 (11) ◽  
pp. 2012-2022 ◽  
Author(s):  
Jaya P. Shrestha ◽  
Yagya Prasad Subedi ◽  
Liaohai Chen ◽  
Cheng-Wei Tom Chang
Keyword(s):  
Cancer Cells ◽  
Anticancer Agents ◽  
Mode Of Action ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
New Class ◽  
Structure Activity ◽  
Sar Study

Previously, we reported the synthesis and structure–activity relationship (SAR) study of a series of novel 4,9-dioxo-4,9-dihydro-1H-naphtho[2,3-d][1,2,3]triazol-3-ium salts, which had very potent anti-proliferative activities (low μM to nM GI50) against a broad range of cancer cells.

Design, synthesis, and structure–activity relationship of new isobenzofuranone ligands of protein kinase C

2004 ◽  
Vol 14 (11) ◽  
pp. 2963-2967 ◽  
Author(s):  
Yoshiyasu Baba ◽  
Yosuke Ogoshi ◽  
Go Hirai ◽  
Takeshi Yanagisawa ◽  
Kumiko Nagamatsu ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Design Synthesis ◽  
Kinase C ◽  
Structure Activity ◽  
Relationship Of
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