Dispersive liquid–liquid microextraction with back extraction using an immiscible organic solvent for determination of benzodiazepines in water, urine, and plasma samples

RSC Advances ◽  
2016 ◽  
Vol 6 (115) ◽  
pp. 114198-114207 ◽  
Author(s):  
Mahnaz Ghambarian ◽  
Fateme Tajabadi ◽  
Yadollah Yamini ◽  
Ali Esrafili
Keyword(s):  
Organic Solvent ◽  
Organic Solvents ◽  
Back Extraction ◽  
Plasma Samples ◽  
Extraction Step ◽  
Dispersive Liquid Liquid Microextraction ◽  
Liquid Microextraction

A novel DLLME method with a back extraction step using two immiscible organic solvents for obtaining higher clean-up than the conventional DLLME method.

scholarly journals A Method to Determination of Lead Ions in Aqueous Samples: Ultrasound-Assisted Dispersive Liquid-Liquid Microextraction Method Based on Solidification of Floating Organic Drop and Back-Extraction Followed by FAAS

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Çiğdem Arpa ◽  
Itır Aridaşir
Keyword(s):  
Aqueous Phase ◽  
Lead Ions ◽  
Extraction Temperature ◽  
Back Extraction ◽  
Extraction Solvent ◽  
Extraction Step ◽  
Ultrasound Assisted ◽  
Dispersive Liquid Liquid Microextraction ◽  
Liquid Microextraction

Ultrasound-assisted dispersive liquid-liquid microextraction method based on solidification of floating organic drop and back-extraction (UA-DLLME-SFO-BE) technique was proposed for preconcentration of lead ions. In this technique, two SFODME steps are applied in sequence. The classical SFODME was applied as the first step and then the second (back-extraction) step was applied. For the classical SFODME, Pb ions were complexed with Congo red at pH 10.0 and then extracted into 1-dodecanol. After this stage, a second extraction step was performed instead of direct determination of the analyte ion in the classical method. For this purpose, the organic phase containing the extracted analyte ions is treated with 1.0 mol·L−1HNO3solution and then exposed to ultrasonication. So, the analyte ions were back-extracted into the aqueous phase. Finally, the analyte ions in the aqueous phase were determined by FAAS directly. Owing to the second extraction step, a clogging problem caused by 1-dodecanol during FAAS determination was avoided. Some parameters which affect the extraction efficiency such as pH, volume of extraction solvent, concentration of complexing agent, type, volume, and concentration of back-extraction solvent, effect of cationic surfactant addition, effect of temperature, and so on were examined. Performed experiments showed that optimum pH was 10.0, 1-dodecanol extraction solvent volume was 75 μL, back-extraction solvent was 500 μL, 1.0 mol·L−1HNO3, extraction time was 4 min, and extraction temperature was 40°C. Under optimum conditions, the enhancement factor, limit of detection, limit of quantification, and relative standard deviation were calculated as 81, 1.9 μg·L−1, 6.4 μg·L−1, and 3.4% (for 25 μg·L−1Pb2+), respectively.

Determination of Fungicides in Fruit Juice by Ultrasound-Assisted Dispersive Liquid–Liquid Microextraction Based on Solidification of Floating Organic Solvent Droplets Followed by High Performance Liquid Chromatography

2014 ◽  
Vol 97 (1) ◽  
pp. 183-187 ◽  
Author(s):  
Run-Zhen Fan ◽  
Congyun Liu ◽  
Wenqing Jiang ◽  
Xiaonan Wang ◽  
Fengmao Liu
Keyword(s):  
Organic Solvent ◽  
High Performance ◽  
Fruit Juice ◽  
Enrichment Factors ◽  
Wide Range ◽  
Separation And Preconcentration ◽  
Ultrasound Assisted ◽  
Dispersive Liquid Liquid Microextraction ◽  
Liquid Microextraction

Abstract Ultrasound-assisted dispersive liquid–liquid microextraction (UA-DLLME) based on solidification of the floating organic solvent droplets (SFO) combined with HPLC was used for determination of five fungicides in fruit juice samples. 1-Dodecanol, which has a low density and low toxicity, was used as the extraction solvent in UA-DLLME. The solidification of floating organic dropletsfacilitates the transfer of analytes from the aqueous phase to the organic phase. This method was easy, quick, inexpensive, precise, and linear over a wide range. Under the optimized conditions, the enrichment factors for a 5 mL fruit juice sample were 25 to 56, and the LODs for the five fungicides ranged from 5 to 50 μg/L. The average recoveries ranged from 71.8 to 118.2% with RSDsof 0.9 to 13.9%. Application of the DLLME-SFO technique allows successful separation and preconcentration of the fungicides at a low concentration level in fruit juice samples.

Dispersive liquid–liquid microextraction coupled with single-drop microextraction for the fast determination of sulfonamides in environmental water samples by high performance liquid chromatography-ultraviolet detection

2016 ◽  
Vol 8 (3) ◽  
pp. 517-525 ◽  
Author(s):  
Xiaoyi Li ◽  
Quanle Li ◽  
Aifang Xue ◽  
Hao Chen ◽  
Shengqing Li
Keyword(s):  
High Performance ◽  
Environmental Water ◽  
Back Extraction ◽  
Single Drop ◽  
Ultraviolet Detection ◽  
Fast Determination ◽  
Single Drop Microextraction ◽  
Dispersive Liquid Liquid Microextraction ◽  
Liquid Microextraction

A simple coupling of low-density solvent-based solvent-demulsification dispersive liquid–liquid microextraction (2-min pre-extraction) and single-drop microextraction (15-min back-extraction).

Application of optimized dispersive liquid–liquid microextraction for determination of melatonin by HPLC–UV in plasma samples

2014 ◽  
Vol 960 ◽  
pp. 1-7 ◽  
Author(s):  
M.S. Talebianpoor ◽  
S. Khodadoust ◽  
A. Rozbehi ◽  
M. Akbartabar Toori ◽  
M. Zoladl ◽  
...  
Keyword(s):  
Plasma Samples ◽  
Dispersive Liquid Liquid Microextraction ◽  
Liquid Microextraction

Ultrasound-Assisted Dispersive Liquid–Liquid Microextraction and Capillary Electrophoretic Determination of Tramadol in Human Plasma

2020 ◽  
Vol 16 ◽  
Author(s):  
Paria Habibollahi ◽  
Azam Samadi ◽  
Alireza Garjani ◽  
Samad Shams Vahdati ◽  
Hamid-Reza Sargazi ◽  
...  
Keyword(s):  
Human Plasma ◽  
Limit Of Detection ◽  
Plasma Samples ◽  
Extraction Solvent ◽  
Human Plasma Samples ◽  
Good Repeatability ◽  
Ultrasound Assisted ◽  
Dispersive Liquid Liquid Microextraction ◽  
Liquid Microextraction

BACKGROUND: Tramadol, (±)-trans-2-[(dimethylamino) methyl]-1-(3-methoxyphenyl) cyclohexanol, is a synthetic centrally acting analgesic used in the treatment of moderate to chronic pain. Tramadol like other narcotic drugs is used for the treatment of pain and also may be abused. Its overdose can cause adverse effects such as dizziness, vomiting, and nausea. The aim of this paper is to develop a sample preparation method for the determination of tramadol in human plasma samples followed by CE analysis. METHODS: Ultrasound assisted-dispersive liquid–liquid microextraction using binary mixed extractant solvent (chloroform and ethyl acetate) was used for extraction of one hundred microliters of tramadol spiked human plasma samples and in real human plasma samples obtained from the patients with abuse of tramadol. After evaporation the extractant solvent, the residue was reconstituted in 100 µL deionized water and subsequently analyzed by CE-UV. RESULTS: The developed method has remarkable characteristics including simplicity, good repeatability and appreciable accuracy. Under the best extraction conditions, low limit of detection at 7.0 µg per liter level with good linearity in the range of 0.02–10 µg mL‒1 was obtained. CONCLUSION: UA-DLLME using a binary mixed extraction solvent was established for the determination of tramadol in human plasma samples via CE method with UV-detection. In addition, the analysis of tramadol in some plasma samples of patients with abuse of tramadol indicated that the method has acceptable performance for determination of tramadol in plasma samples which indicate that the method is suitable for clinical applications.

Ligandless dispersive liquid–liquid microextraction combined with syringe to syringe back extraction for the determination of lead in water samples by flame atomic absorption spectrometry

2017 ◽  
Vol 9 (32) ◽  
pp. 4673-4679 ◽  
Author(s):  
Li Yao ◽  
Wenzhi Xu ◽  
Chaowen Lin ◽  
Yongqun Zhu ◽  
Fuxiang Luo ◽  
...  
Keyword(s):  
Atomic Absorption Spectrometry ◽  
Atomic Absorption ◽  
Flame Atomic Absorption Spectrometry ◽  
Water Samples ◽  
Absorption Spectrometry ◽  
Back Extraction ◽  
Flame Atomic Absorption ◽  
Dispersive Liquid Liquid Microextraction ◽  
Liquid Microextraction

Ligandless DLLME combined with syringe to syringe back extraction was applied for the preconcentration of Pb prior to analysis by FAAS.

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