Ultra-sensitive diagnosis of orthotopic patient derived hepatocellular carcinoma by Fe@graphene nanoparticles in MRI

RSC Advances ◽  
2016 ◽  
Vol 6 (115) ◽  
pp. 113919-113923 ◽  
Author(s):  
Chao Zhang ◽  
Jing Ren ◽  
Yutong Yang ◽  
Dunhui Wang ◽  
Jian He ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cancer Detection ◽  
Diagnostic Ability ◽  
Magnetic Performance ◽  
Graphene Nanoparticles ◽  
Low Cytotoxicity

mPEG-DSPE modified Fe/graphene nanoparticles showed low cytotoxicity and high magnetic performance, providing super MRI diagnostic ability for cancer detection.

Differentiation between hepatocellular carcinoma and intrahepatic cholangiocarcinoma using contrast-enhanced ultrasound: A systematic review and meta-analysis

2021 ◽  
pp. 1-17
Author(s):  
Yanling Chen ◽  
Wenping Wang
Keyword(s):  
Hepatocellular Carcinoma ◽  
Diagnostic Accuracy ◽  
Publication Bias ◽  
Likelihood Ratio ◽  
Intrahepatic Cholangiocarcinoma ◽  
Cochrane Library ◽  
Arterial Phase ◽  
Contrast Enhanced Ultrasound ◽  
Diagnostic Ability ◽  
Contrast Enhanced

AIM: To explore the diagnostic ability of contrast-enhanced ultrasound (CEUS) in distinguishing intrahepatic cholangiocarcinoma (ICC) from hepatocellular carcinoma (HCC). MATERIALS AND METHODS: PubMed, EMBASE, Cochrane Library, and Web of Science were systematically searched for studies reporting the diagnostic accuracy of CEUS in differentiating ICC from HCC. The diagnostic ability of CEUS was assessed based on the pooled sensitivity, specificity, diagnostic odds ratio (DOR), positive likelihood ratio (PLR), negative likelihood ratio (NLR) and area under the curve (AUC) with 95% confidence intervals (CIs). The methodologic quality was assessed by the QUADAS-2 tool. Subgroup analyses, meta-regression and investigation of publication bias were performed to identify the source of heterogeneity. RESULTS: A total of eight studies were included, consisting of 1,116 patients with HCC and 529 with ICC. The general diagnostic performance of CEUS in distinguishing ICC and HCC were as follows: pooled sensitivity, 0.92 (95% CI: 0.84–0.96); pooled specificity, 0.87 (95% CI: 0.79–0.92); pooled PLR, 7.1 (95% CI: 4.1–12.0); pooled NLR, 0.09 (95% CI: 0.05–0.19); pooled DOR, 76 (95% CI: 26–220) and AUC, 0.95(95% CI: 0.93–0.97). Different liver background may be a potential factor that influenced the diagnostic accuracy of CEUS according to the subgroup analysis, with the pooled DOR of 89.67 in the mixed liver background group and 46.87 in the cirrhosis group, respectively. Six informative CEUS features that may help differentiate HCC from ICC were extracted. The three CEUS features favoring HCC were arterial phase hyperenhancement(APHE), mild washout and late washout (>60s); the three CEUS favoring ICC were arterial rim enhancement, marked washout and early washout(<60s). No potential publication bias was observed. CONCLUSION: CEUS showed great diagnostic ability in differentiating ICC from HCC, which may be promising for noninvasive evaluation of these diseases.

Lenvatinib and Cu2-XS nanocrystals co-encapsulated in poly(D,L-lactide-co-glycolide) for synergistic chemo-photothermal therapy against advanced hepatocellular carcinoma

2021 ◽  
Author(s):  
Qi Xu ◽  
Qiuting Li ◽  
Zhe Yang ◽  
Piao Huang ◽  
Han Hu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Multidrug Resistance ◽  
Photothermal Therapy ◽  
Advanced Hepatocellular Carcinoma ◽  
Anticancer Effect ◽  
Targeted Drug ◽  
Low Cytotoxicity

Lenvatinib (LT) is gradually replacing sorafenib as an alternative targeted drug for advanced hepatocellular carcinoma (HCC). However, the anticancer effect of LT is still limited by low cytotoxicity, multidrug resistance...

SCCA1–IGM and SCCA2–IGM Compared with Total SCCA-IGM for Diagnosis of Hepatocellular Carcinoma

2009 ◽  
Vol 24 (3) ◽  
pp. 205-205
Author(s):  
Alessandra Biasiolo ◽  
Natascia Tono ◽  
Santina Quarta ◽  
Luca Beneduce ◽  
Angelo Gatta ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cancer ◽  
Cancer Detection ◽  
Immune Complexes ◽  
Primary Liver Cancer ◽  
Diagnostic Sensitivity ◽  
Serum Samples ◽  
Sensitivity Score ◽  
Commercial Assay ◽  
The Family

Introduction SCCA1 and SCCA2 belong to the family of serine protease inhibitors (SERPIN). Both SCCA isoforms have been found to be increased in patients with squamous cell carcinoma (SCC) of different organs. Recent findings have demonstrated that SCCA-IgM immune complexes are a novel class of biomarkers for primary liver cancer detection. An increase in SCCA-IgM levels in patients with cirrhosis is associated with the development of liver cancer. Aims and methods To evaluate the diagnostic accuracy of different isoforms of SCCA-IgM compared with a commercial assay for SCCA-IgM in patients with hepatocellular carcinoma (HCC). Twenty-six patients with HCC (M/F 1 9/7; mean age ± SD: 65 ± 13 years) were analyzed. Serum samples from 28 blood donors (M/F 17/11; mean age ± SD: 38 ± 9 years) were used as control. Two monoclonal antibodies, SCC 111 and SCC 1 04 (CanAg Diagnostics, Gothenburg, Sweden) were used as catcher antibodies to perform specific ELISA for SCCA1-lgM and SCCA2-lgM. SCCA-IgM immune complexes were also detected in serum by a commercial ELISA kit (Hepa-IC, Xeptagen, Marghera, Italy) according to the manufacturer's instructions. Results Circulating SCCA1-IgM was detectable in 6 out of 26 patients (sensitivity 23%), while SCCA2-lgM ELISA was positive in 9 of 26 patients (sensitivity 35%). When SCCA-IgM levels were measured using the commercial assay the diagnostic sensitivity increased to 58% (15/26). The SCCA1-IgM, SCCA2-lgM and SCCA-IgM tests had 100% specificity in healthy controls. Conclusions The commercial assay allowed the detection of both isoforms of SCCA forming the IgM immune complexes, providing a better diagnostic sensitivity score than that obtained with the SCCA1-IgM or SCCA2-lgM test.

scholarly journals Restricted Boltzmann Machines for Classification of Hepatocellular Carcinoma

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
James A. Koziol ◽  
Eng M. Tan ◽  
Liping Dai ◽  
Pengfei Ren ◽  
Jian-Ying Zhang
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cancer Detection ◽  
Classification Problem ◽  
Classification Problems ◽  
Operating Characteristics ◽  
Restricted Boltzmann Machines ◽  
Boltzmann Machines ◽  
Multiple Antigen ◽  
Detection And Diagnosis

Multiple antigen miniarrays can provide accurate tools for cancer detection and diagnosis. These miniarrays can be validated by examining their operating characteristics in classifying individuals as either cancer patients or normal (non-cancer) subjects. We describe the use of restricted Boltzmann machines for this classification problem, relative to diagnosis of hepatocellular carcinoma. In this setting, we find that its operating characteristics are similar to a logistic regression standard and suggest that restricted Boltzmann machines merit further consideration for classification problems.

scholarly journals A three-miRNA panel in serum as a noninvasive biomarker for colorectal cancer detection

2020 ◽  
Vol 35 (3) ◽  
pp. 74-82
Author(s):  
Xiqi Peng ◽  
Jingyao Wang ◽  
Chunduo Zhang ◽  
Kaihao Liu ◽  
Liwen Zhao ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Receiver Operating Characteristic ◽  
Cancer Detection ◽  
Operating Characteristic ◽  
Target Genes ◽  
Healthy Controls ◽  
Characteristic Analysis ◽  
Diagnostic Ability ◽  
Noninvasive Biomarker ◽  
Receiver Operating

Background: Circulating miRNAs have been proved to be promising biomarkers for disease detection in recent years. The present study aimed at exploring available serum miRNA biomarkers for the detection of colorectal cancer. Methods: A three-phase study was performed to select and validate candidate miRNAs with significant dysregulation in colorectal cancer using quantitative reverse transcription-polymerase chain reaction. This study recruited 137 colorectal cancer patients and 145 healthy controls. The diagnostic values of miRNAs were evaluated by receiver operating characteristic analysis. Bioinformatics analyses were utilized to predict target genes of miRNAs, and to conduct functional annotation and enrichment. Results: miR-30e-3p, miR-31-5p, miR-34b-3p and miR-146a-5p, miR-148a-3p and miR-192-5p were significantly dysregulated in colorectal cancer serum when compared with healthy controls. The panel composed of miR-30e-3p, miR-146a-5p, and miR-148a-3p exhibited strong diagnostic ability. The area under the receiver operating characteristic curve of the three-miRNA panel was 0.883, with a sensitivity of 0.800 and specificity of 0.787. Conclusion: The present study identified a three-miRNA panel in serum with a strong diagnostic ability of colorectal cancer, which may be able to serve as a novel noninvasive biomarker for colorectal cancer detection.

The advances in applying inorganic fluorescent nanomaterials for the detection of hepatocellular carcinoma and other cancers

RSC Advances ◽  
2015 ◽  
Vol 5 (97) ◽  
pp. 79572-79584 ◽  
Author(s):  
Hetao Chen ◽  
Dongxing Shi ◽  
Yu Wang ◽  
Liwen Zhang ◽  
Qiang Zhang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cancer Detection ◽  
Fluorescent Nanomaterials

The advances, drawbacks and application suggestions of QDs, UCNPs and CDs in HCC and other cancer detection fields are discussed.

Theranostic liposomes as nanodelivered chemotherapeutics enhanced the microwave ablation of hepatocellular carcinoma

Nanomedicine ◽  
2019 ◽  
Vol 14 (16) ◽  
pp. 2151-2167 ◽  
Author(s):  
Qunfang Zhou ◽  
Kun Wang ◽  
Jianping Dou ◽  
Feng Cao ◽  
Fengyong Liu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Indocyanine Green ◽  
Liver Tissue ◽  
Microwave Ablation ◽  
Normal Liver ◽  
Tumor Uptake ◽  
Diagnostic Ability ◽  
Ablation Efficiency ◽  
Tomography Imaging ◽  
Optoacoustic Tomography

Aim: This study aimed to develop indocyanine green- and doxorubicin-loaded liposomes (DILPs) as theranostic nanoplatform for the detection of hepatocellular carcinoma (HCC) and as an efficient chemotherapeutic to enhance microwave ablation. Materials & methods: DILPs were synthesized and thoroughly characterized. Biocompatibility, tumor uptake and accumulation, and synergistic ablation-chemotherapeutic efficiency were systematically explored in them. In addition, human HCC surgical samples were used to test the affinity of DILPs for HCC. Results: The combination of microwave ablation and DILPs enhanced the ablation efficiency of HCC with apparent tumor inhibition. DILPs exhibited excellent diagnostic ability and could detect 2.5-mm HCC lesions via optoacoustic tomography imaging. DILPs had better affinity for human HCC surgical samples compared with normal liver tissue. Conclusion: Theranostic DILPs could serve as promising nanoparticles for treatment and management of HCC in the clinic.

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