Synthesis of amine-polyglycidol functionalised Fe3O4@SiO2nanocomposites for magnetic hyperthermia, pH-responsive drug delivery, and bioimaging applications

RSC Advances ◽  
2016 ◽  
Vol 6 (111) ◽  
pp. 110444-110453 ◽  
Author(s):  
Madhappan Santha Moorthy ◽  
Yunok Oh ◽  
Subramanian Bharathiraja ◽  
Panchanathan Manivasagan ◽  
Thenmozhi Rajarathinam ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Contrast Agent ◽  
Magnetic Hyperthermia ◽  
Ph Responsive ◽  
Drug Delivery Carrier

We report the biocompatible Fe3O4@SiO2@APG-F nanocomposite for drug delivery and hyperthermia applications. The Fe3O4@SiO2@APG-F nanocomposite could serve as a good hyperthermia agent, drug delivery carrier, and fluorescent contrast agent.

Crown ether triad modified core–shell magnetic mesoporous silica nanocarrier for pH-responsive drug delivery and magnetic hyperthermia applications

2017 ◽  
Vol 41 (19) ◽  
pp. 10935-10947 ◽  
Author(s):  
Madhappan Santha Moorthy ◽  
Subramanian Bharathiraja ◽  
Panchanathan Manivasagan ◽  
Kang Dae Lee ◽  
Junghwan Oh
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Crown Ether ◽  
Magnetic Hyperthermia ◽  
Core Shell ◽  
Ph Responsive ◽  
Magnetic Mesoporous Silica

A “host–guest” complexation-based core–shell FeNP@SiOH@CET NP system was fabricated for chemotherapy and magnetic hyperthermia applications.

Synthesis of Fe3O4 modified mesoporous silica hybrid for pH-responsive drug delivery and magnetic hyperthermia applications

2017 ◽  
Vol 25 (4) ◽  
pp. 1251-1264 ◽  
Author(s):  
Madhappan Santha Moorthy ◽  
Subramanian Bharathiraja ◽  
Panchanathan Manivasagan ◽  
Yunok Oh ◽  
Thi Tuong Vy Phan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Magnetic Hyperthermia ◽  
Ph Responsive ◽  
Silica Hybrid

Nanostructures for pH-sensitive Drug Delivery and Magnetic Resonance Contrast Enhancement Systems

2018 ◽  
Vol 25 (25) ◽  
pp. 3036-3057 ◽  
Author(s):  
Xiao Sun ◽  
Guilong Zhang ◽  
Zhengyan Wu
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
Drug Release ◽  
Contrast Enhancement ◽  
General Strategy ◽  
Ph Responsive ◽  
Physicochemical Changes ◽  
Magnetic Resonance Contrast ◽  
Resonance Contrast ◽  
Magnetic Resonance Contrast Enhancement

According to the differences of microenvironments between tumors and healthy tissues, if the anticancer drugs or magnetic resonance contrast agents (MRCAs) can be controlled to precisely match physiological needs at targeted tumor sites, it is expected to acquire better therapeutic efficacy and more accurate diagnosis. Over the decade, stimuli-responsive nanomaterials have been a research hotspot for cancer treatment and diagnosis because they show many excellent functions, such as in vivo imaging, combined targeting drug delivery and systemic controlled release, extended circulation time, etc. Among the various stimuli nanosystems, pH-stimuli mode is regarded as the most general strategy because of solid tumors acidosis. When exposed to weakly acidic tumor microenvironment, pH-responsive nanoplatforms can generate physicochemical changes for their structure and surface characteristics, causing drug release or contrast enhancement. In this review, we focused on the designs of various pH-responsive nanoplatforms and discussed the mechanisms of controlled drug release or switch on-off in MRCAs. This review also discussed the efficacy of cellular internalization for these nanoplatforms via endocytosis of acidic tumor cell. Meanwhile, nanoplatforms response to acidic intracellular pH (such as endosome, lysosome) are discussed, along with approaches for improving drug release performance and magnetic resonance contrast enhancement. A greater understanding of these pH-responsive nanoplatforms will help design more efficient nanomedicine to address the challenges encountered in conventional diagnosis and chemotherapy.

Synthesis of pH-responsive triazine skeleton nano-polymer composite containing AIE group for drug delivery

2021 ◽  
Author(s):  
Yifan Zhang ◽  
Xueying Peng ◽  
Xinbo Jing ◽  
Lin Cui ◽  
Shengchao Yang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polymer Composite ◽  
Ph Responsive

scholarly journals pH and redox dual-sensitive drug delivery system constructed based on fluorescent carbon dots

RSC Advances ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 2656-2663
Author(s):  
Boye Zhang ◽  
Qianqian Duan ◽  
Yi Li ◽  
Jianming Wang ◽  
Wendong Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Cancer Cells ◽  
Fluorescence Imaging ◽  
Drug Delivery System ◽  
Delivery System ◽  
Carbon Dots ◽  
Ph Responsive ◽  
Charge Reversal ◽  
Fluorescent Carbon Dots

The system is pH-responsive and redox-controlled release. And the charge reversal and size transitions of the system can enhance the targeted ability. Moreover, the system can recognize the cancer cells by the fluorescence imaging.

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