Star-shape paclitaxel prodrug self-assembled nanomedicine: combining high drug loading and enhanced cytotoxicity

RSC Advances ◽  
2016 ◽  
Vol 6 (110) ◽  
pp. 109076-109082 ◽  
Author(s):  
Mengjuan Jiang ◽  
Xiangfei Han ◽  
Weiling Guo ◽  
Wei Li ◽  
Jinling Chen ◽  
...  
Keyword(s):  
Drug Loading ◽  
High Drug ◽  
Self Assembled ◽  
High Drug Loading

Star-shape paclitaxel prodrugs self-assembled nanoparticles combining high drug loading and enhanced cytotoxicity.

Novel dual VES phospholipid self-assembled liposomes with an extremely high drug loading efficiency

2017 ◽  
Vol 156 ◽  
pp. 29-37 ◽  
Author(s):  
Yongpeng Hou ◽  
Chen Yao ◽  
Longbing Ling ◽  
Yawei Du ◽  
Ruiyu He ◽  
...  
Keyword(s):  
Drug Loading ◽  
High Drug ◽  
Loading Efficiency ◽  
Drug Loading Efficiency ◽  
Self Assembled ◽  
High Drug Loading

Superior antitumor effect of extremely high drug loading self-assembled paclitaxel nanofibers

2017 ◽  
Vol 526 (1-2) ◽  
pp. 217-224 ◽  
Author(s):  
Huae Xu ◽  
Xiaowei Lu ◽  
Jun Li ◽  
Dan Ding ◽  
Hong Wang ◽  
...  
Keyword(s):  
Antitumor Effect ◽  
Drug Loading ◽  
High Drug ◽  
Self Assembled ◽  
High Drug Loading

A High-Drug-Loading Self-Assembled Nanoemulsion Enhances the Oral Absorption of Probucol in Rats

2013 ◽  
Vol 102 (4) ◽  
pp. 1301-1306 ◽  
Author(s):  
Zhiwen Zhang ◽  
Jian Huang ◽  
Shijun Jiang ◽  
Zeying Liu ◽  
Gu Wangwen ◽  
...  
Keyword(s):  
Oral Absorption ◽  
Drug Loading ◽  
High Drug ◽  
Self Assembled ◽  
High Drug Loading

Self-assembled nanomedicine combining a berberine derivative and doxorubicin for enhanced antitumor and antimetastatic efficacy via mitochondrial pathways

Nanoscale ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 6605-6623
Author(s):  
Chuchu Lin ◽  
Xuan Yang ◽  
Huatian Li ◽  
Yiqing Zou ◽  
Imran Shair Mohammad ◽  
...  
Keyword(s):  
Drug Loading ◽  
Tumor Proliferation ◽  
High Drug ◽  
Proliferation And Metastasis ◽  
Self Assembled ◽  
High Drug Loading ◽  
Tumor Proliferation And Metastasis

A self-assembled nanomedicine combining Ber and Dox with high drug loading was developed, which could translocate Dox from the nucleus to mitochondria and finally inhibit tumor proliferation and metastasis simultaneously via mitochondrial pathways.

scholarly journals A novel self-assembled sandwich nanomedicine for NIR-responsive release of NO

Nanoscale ◽  
2015 ◽  
Vol 7 (47) ◽  
pp. 20055-20062 ◽  
Author(s):  
Jing Fan ◽  
Nongyue He ◽  
Qianjun He ◽  
Yi Liu ◽  
Ying Ma ◽  
...  
Keyword(s):  
Drug Loading ◽  
Loading Capacity ◽  
High Drug ◽  
No Release ◽  
Self Assembled ◽  
High Drug Loading

A sandwich nanomedicine self-assembled by GO nanosheets and BNN6 exhibits high drug loading capacity and NIR responsiveness for NO release.

Investigating the influence of aromatic moieties on the formulation of hydrophobic natural products and drugs in poly(2-oxazoline) based amphiphiles

2018 ◽  
Author(s):  
Robert Luxenhofer ◽  
Michael M Lübtow ◽  
Lukas Hahn ◽  
Thomas Lorson ◽  
Rainer Schobert
Keyword(s):  
Natural Products ◽  
Small Molecules ◽  
Water Solubility ◽  
Drug Loading ◽  
High Drug ◽  
Long Term Stability ◽  
Aromatic Content ◽  
Important Interaction ◽  
Amorphous Structures ◽  
High Drug Loading

Many natural compounds with interesting biomedical properties share one physicochemical property, namely a low water solubility. Polymer micelles are, among others, a popular means to solubilize hydrophobic compounds. The specific molecular interactions between the polymers and the hydrophobic drugs are diverse and recently it has been discussed that macromolecular engineering can be used to optimize drug loaded micelles. Specifically, π-π stacking between small molecules and polymers has been discussed as an important interaction that can be employed to increase drug loading and formulation stability. Here, we test this hypothesis using four different polymer amphiphiles with varying aromatic content and various natural products that also contain different relative amounts of aromatic moieties. While in the case of paclitaxel, having the lowest relative content of aromatic moieties, the drug loading decreases with increasing relative aromatic amount in the polymer, the drug loading of curcumin, having a much higher relative aromatic content, is increased. Interestingly, the loading using schizandrin A, a dibenzo[a,c]cyclooctadiene lignan with intermediate relative aromatic content is not influenced significantly by the aromatic content of the polymers employed. The very high drug loading, long term stability, the ability to form stable highly loaded binary coformulations in different drug combinations, small sized formulations and amorphous structures in all cases, corroborate earlier reports that poly(2-oxazoline) based micelles exhibit an extraordinarily high drug loading and are promising candidates for further biomedical applications. The presented results underline that the interaction between the polymers and the incorporated small molecules are complex and must be investigated in every specific case.<br>

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