scholarly journals A combined therapy of rtPA-loaded thermoresponsive gels and ultrasound on hematoma in a rat model of intracerebral hemorrhage

RSC Advances ◽  
2017 ◽  
Vol 7 (26) ◽  
pp. 15809-15816 ◽  
Author(s):  
Wei Sun ◽  
Zhongxin Qian ◽  
Mingzhu Zhao ◽  
Ming Shen ◽  
Yourong Duan ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Plasminogen Activator ◽  
Rat Model ◽  
Combined Therapy ◽  
Pluronic F127 ◽  
Tissue Type ◽  
Intracerebral Hematoma ◽  
Tissue Type Plasminogen Activator ◽  
Type Plasminogen Activator ◽  
Neurological Response

To develop and validate an effective method for the removal of residual intracerebral hematoma, we prepared a recombinant tissue-type plasminogen activator (rtPA)-loaded Pluronic F127 (NP-rtPA) delivery system to evaluate the neurological response of the ICH rat model.

scholarly journals Plasminogen Activator Inhibitor-1 Induction after Experimental Intracerebral Hemorrhage

2002 ◽  
Vol 22 (1) ◽  
pp. 55-61 ◽  
Author(s):  
Ya Hua ◽  
Guohua Xi ◽  
Richard F. Keep ◽  
Jimin Wu ◽  
Yajun Jiang ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Plasminogen Activator ◽  
Serine Proteases ◽  
Plasminogen Activator Inhibitor ◽  
Tissue Type ◽  
Plasminogen Activator Inhibitor 1 ◽  
Tissue Type Plasminogen Activator ◽  
Protein Levels ◽  
Type Plasminogen Activator ◽  
Activator Inhibitor

Serine proteases, such as thrombin and tissue-type plasminogen activator, play an important role in brain injury after intracerebral hemorrhage and other neurologic disorders. Plasminogen activator inhibitor-1 is one of the serine protease inhibitors, or serpins. The balance between serine proteases and serpins may affect the outcome of intracerebral hemorrhage. The purpose of this study was to determine whether plasminogen activator inhibitor-1 and tissue-type plasminogen activator are upregulated after intracerebral hemorrhage and the role that thrombin plays in that induction. Plasminogen activator inhibitor-1 protein levels were upregulated after intracerebral hemorrhage. Brain plasminogen activator inhibitor-1 content also increased after thrombin infusion in a dose-dependent manner. Hirudin, a specific thrombin inhibitor, blocked the upregulation of plasminogen activator inhibitor-1 after intracerebral hemorrhage. Time courses showed that plasminogen activator inhibitor-1 levels around the hematoma peaked at the first day. Plasminogen activator inhibitor-1–positive cells were detected in the perihematomal area and the ipsilateral basal ganglia after thrombin infusion, but not in the contralateral hemisphere. Plasminogen activator inhibitor-1 messenger RNA levels were increased at 24 hours after intracerebral hemorrhage and after thrombin infusion. However, tissue-type plasminogen activator protein levels were the same in the control, whole-blood, and thrombin-infusion groups. In conclusion, intracerebral hemorrhage and thrombin infusion stimulate plasminogen activator inhibitor-1 but not tissue-type plasminogen activator production in the brain. The upregulation of plasminogen activator inhibitor-1 may be neuroprotective by limiting thrombin or other serine protease-induced toxicity.

Microvascular repair following a modified crush-avulsion injury in a rat model: Effect of recombinant human tissue-type plasminogen activator on the patency rate

Microsurgery ◽  
2000 ◽  
Vol 20 (2) ◽  
pp. 52-58 ◽  
Author(s):  
Efstathios G. Lykoudis ◽  
Petros N. Panayotou ◽  
Constantinos N. Stamatopoulos ◽  
Konstantina B. Frangia ◽  
Apostolos E. Papalois ◽  
...  
Keyword(s):  
Plasminogen Activator ◽  
Rat Model ◽  
Human Tissue ◽  
Patency Rate ◽  
Tissue Type ◽  
Tissue Type Plasminogen Activator ◽  
Avulsion Injury ◽  
Type Plasminogen Activator

scholarly journals A Rat Model of Studying Tissue-Type Plasminogen Activator Thrombolysis in Ischemic Stroke With Diabetes

Stroke ◽  
2012 ◽  
Vol 43 (2) ◽  
pp. 567-570 ◽  
Author(s):  
Xiang Fan ◽  
Jianhua Qiu ◽  
Zhanyang Yu ◽  
Haibin Dai ◽  
Aneesh B. Singhal ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Plasminogen Activator ◽  
Rat Model ◽  
Tissue Type ◽  
Tissue Type Plasminogen Activator ◽  
Type Plasminogen Activator
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