Cadmium(ii) carboxyphosphonates based on mixed ligands: syntheses, crystal structures and recognition properties toward amino acids

RSC Advances ◽  
2016 ◽  
Vol 6 (95) ◽  
pp. 92175-92185 ◽  
Author(s):  
Zhou Zhao ◽  
Dan Yang ◽  
Bo Xing ◽  
Chao Ma ◽  
Zhen-Gang Sun ◽  
...  
Keyword(s):  
Amino Acids ◽  
Crystal Structures ◽  
Selective Recognition ◽  
Luminescence Properties ◽  
Mixed Ligands

Three novel cadmium(ii) carboxyphosphonates have been hydrothermally synthesized. The luminescence properties of compounds 1–3 have been investigated. Meanwhile, the excellent abilities of compounds 2 and 3 for selective recognition of tryptophan (Trp) have been demonstrated.

scholarly journals Selective Recognition of Amino Acids and Peptides by Small Supramolecular Receptors

Molecules ◽  
2020 ◽  
Vol 26 (1) ◽  
pp. 106
Author(s):  
Joana N. Martins ◽  
João Carlos Lima ◽  
Nuno Basílio
Keyword(s):  
Amino Acids ◽  
Selective Recognition ◽  
Great Promise ◽  
Macrocyclic Compounds ◽  
Synthetic Receptors ◽  
Small Peptides ◽  
Molecular Imprinted Polymers ◽  
Polymeric Systems ◽  
Physiological Conditions ◽  
Level Information

To this day, the recognition and high affinity binding of biomolecules in water by synthetic receptors remains challenging, while the necessity for systems for their sensing, transport and modulation persists. This problematic is prevalent for the recognition of peptides, which not only have key roles in many biochemical pathways, as well as having pharmacological and biotechnological applications, but also frequently serve as models for the study of proteins. Taking inspiration in nature and on the interactions that occur between several receptors and peptide sequences, many researchers have developed and applied a variety of different synthetic receptors, as is the case of macrocyclic compounds, molecular imprinted polymers, organometallic cages, among others, to bind amino acids, small peptides and proteins. In this critical review, we present and discuss selected examples of synthetic receptors for amino acids and peptides, with a greater focus on supramolecular receptors, which show great promise for the selective recognition of these biomolecules in physiological conditions. We decided to focus preferentially on small synthetic receptors (leaving out of this review high molecular weight polymeric systems) for which more detailed and accurate molecular level information regarding the main structural and thermodynamic features of the receptor biomolecule assemblies is available.

scholarly journals Structural basis of adhesive binding by desmocollins and desmogleins

2016 ◽  
Vol 113 (26) ◽  
pp. 7160-7165 ◽  
Author(s):  
Oliver J. Harrison ◽  
Julia Brasch ◽  
Gorka Lasso ◽  
Phinikoula S. Katsamba ◽  
Goran Ahlsen ◽  
...  
Keyword(s):  
Amino Acids ◽  
Crystal Structures ◽  
Structural Basis ◽  
Cellular Interactions ◽  
Opposite Charge ◽  
Charged Amino Acids ◽  
Structural Framework ◽  
Classical Cadherins ◽  
Coated Bead

Desmosomes are intercellular adhesive junctions that impart strength to vertebrate tissues. Their dense, ordered intercellular attachments are formed by desmogleins (Dsgs) and desmocollins (Dscs), but the nature of trans-cellular interactions between these specialized cadherins is unclear. Here, using solution biophysics and coated-bead aggregation experiments, we demonstrate family-wise heterophilic specificity: All Dsgs form adhesive dimers with all Dscs, with affinities characteristic of each Dsg:Dsc pair. Crystal structures of ectodomains from Dsg2 and Dsg3 and from Dsc1 and Dsc2 show binding through a strand-swap mechanism similar to that of homophilic classical cadherins. However, conserved charged amino acids inhibit Dsg:Dsg and Dsc:Dsc interactions by same-charge repulsion and promote heterophilic Dsg:Dsc interactions through opposite-charge attraction. These findings show that Dsg:Dsc heterodimers represent the fundamental adhesive unit of desmosomes and provide a structural framework for understanding desmosome assembly.

Synthesis, crystal structures and insulin-like activity of two new oxidovanadium(V) complexes with aroylhydrazones and maltol mixed-ligands

Polyhedron ◽  
2017 ◽  
Vol 137 ◽  
pp. 321-324 ◽  
Author(s):  
Xiang-Fei Chen ◽  
Tian-Rui Wang ◽  
Zheng Ma ◽  
Yan Yu ◽  
Ling Tang ◽  
...  
Keyword(s):  
Crystal Structures ◽  
Mixed Ligands ◽  
Insulin Like Activity

Chiral Ferrocene Amines Derived from Amino Acids and Peptides:  Synthesis, Solution and X-ray Crystal Structures and Electrochemical Investigations

2000 ◽  
Vol 39 (24) ◽  
pp. 5437-5443 ◽  
Author(s):  
Alexandra Hess ◽  
Jan Sehnert ◽  
Thomas Weyhermüller ◽  
Nils Metzler-Nolte
Keyword(s):  
Amino Acids ◽  
Crystal Structures ◽  
X Ray ◽  
Peptides Synthesis ◽  
Synthesis Solution

Synthesis, crystal structures and luminescence properties of two metal carboxyphosphonates

2017 ◽  
Vol 249 ◽  
pp. 136-140 ◽  
Author(s):  
Chaonan Wang ◽  
Pingjing Feng ◽  
Jintang Li ◽  
Xuetao Luo
Keyword(s):  
Crystal Structures ◽  
Luminescence Properties
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