Preferred formation of the carboxylic acid–pyridine heterosynthon in 2-anilinonicotinic acids

RSC Advances ◽  
2016 ◽  
Vol 6 (84) ◽  
pp. 81101-81109 ◽  
Author(s):  
Peng Chen ◽  
Zhifei Zhang ◽  
Sean Parkin ◽  
Panpan Zhou ◽  
Kai Cheng ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Nicotinic Acid ◽  
Structural Modification

Preferred formation of carboxylic acid–pyridine heterosynthon in 2-(phenylamino)nicotinic acid was realized through structural modification of the N bridge.

Structural Modification of a Periodic Polypeptide through Biosynthetic Replacement of Proline with Azetidine-2-carboxylic Acid

1996 ◽  
Vol 29 (5) ◽  
pp. 1442-1444 ◽  
Author(s):  
Timothy J. Deming ◽  
Maurille J. Fournier ◽  
Thomas L. Mason ◽  
David A. Tirrell
Keyword(s):  
Carboxylic Acid ◽  
Structural Modification

Structural modification and new methods for preparation of ofloxacin analogs

1991 ◽  
Vol 56 (9) ◽  
pp. 1937-1943 ◽  
Author(s):  
Stanislav Rádl ◽  
Lenka Kovářová ◽  
Jaroslav Moural ◽  
Radoslava Bendová
Keyword(s):  
Carboxylic Acid ◽  
Structural Modification ◽  
Sodium Hydrogen Carbonate ◽  
Methyl Derivative ◽  
New Methods ◽  
Sodium Hydrogen ◽  
Hydrogen Carbonate ◽  
Alkaline Conditions ◽  
Methylene Derivative

Reaction of ethyl 2-(2,4-dichloro-5-fluoro-3-nitrobenzoyl)-3-ethoxyacrylate IIb with 2-amino-1-propanol provided corresponding compound IIIb which under alkaline conditions underwent an aromatic denitrocyclization reaction which after alkaline saponification provided 10-chloro-9-fluoro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid Vd. Treatment of 8-hydroxyquinolone VIII with 3-bromopropyne in the presence of sodium hydrogen carbonate provided methylene derivative VIIb which was saponified into a appropriate acid VIIc. Compound VIIb treated with N-methylpiperazine and then saponified yielded VIIa. Hydrogenation of 3-methylene derivative VIIb provided 3-methyl derivative Va.

Thermochemistry of aqueous pyridine-3-carboxylic acid (nicotinic acid)

2011 ◽  
Vol 43 (6) ◽  
pp. 974-979 ◽  
Author(s):  
Elsa M. Gonçalves ◽  
Talita S. Rego ◽  
Manuel E. Minas da Piedade
Keyword(s):  
Carboxylic Acid ◽  
Nicotinic Acid

The Effect of Nicotinic Acid, 5-Methylpyrazole-3-carboxylic Acid (U-19425), and Dibutyryl Cyclic AMP on Renal Gluconeogenesis

1971 ◽  
Vol 49 (2) ◽  
pp. 102-105
Author(s):  
Andrew Issekutz
Keyword(s):  
Carboxylic Acid ◽  
Cyclic Amp ◽  
Nicotinic Acid ◽  
Kidney Cortex ◽  
Dibutyryl Cyclic Amp ◽  
Renal Gluconeogenesis ◽  
Minimal Concentration ◽  
Cortex Slices ◽  
Glucose Formation ◽  
Kidney Cortex Slices

The effects of nicotinic acid, 5-methylpyrazole-3-carboxylic acid (U-19425), and dibutyryl (DB-) cyclic AMP on gluconeogenesis from lactate, oxalacetate, and glycerol were studied in kidney cortex slices. DB-cyclic AMP stimulated glucose formation from lactate (+67%), but not from oxalacetate or glycerol. Nicotinic acid and U-19425 inhibited gluconeogenesis from all three substrates by 30–63%. DB-cyclic AMP stimulated gluconeogenesis from lactate in the presence of either inhibitor. DB-cyclic AMP abolished the inhibition by either drug on glucose formation from oxalacetate or glycerol. It is concluded that nicotinic acid and U-19425 may inhibit gluconeogenesis by decreasing the cyclic AMP level within the cells, and that a minimal concentration of cyclic AMP may be functional above the triose phosphate level.

Synthesis and structural modification of tert-butyl ester of 7α-chloro-2-(N,N-dimethylaminomethylene)-3-methyl-1,1-dioxoceph-3-em-4-carboxylic acid

2007 ◽  
Vol 43 (5) ◽  
pp. 646-652 ◽  
Author(s):  
M. Vorona ◽  
I. Potoročina ◽  
G. Veinberg ◽  
I. Shestakova ◽  
I. Kanepe ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Structural Modification ◽  
Butyl Ester ◽  
Tert Butyl
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