Multifunctional iron oxide–carbon hybrid microrods

RSC Advances ◽  
2016 ◽  
Vol 6 (101) ◽  
pp. 98845-98853 ◽  
Author(s):  
Lu Zhu ◽  
Weijie Huang ◽  
Zachary S. Rinehart ◽  
Jason Tam ◽  
Yiping Zhao
Keyword(s):  
Iron Oxide ◽  
Solvothermal Synthesis ◽  
Drug Loading ◽  
Dye Adsorption

FexOy–C microrods with superior dye adsorption and drug loading abilities were obtained by solvothermal synthesis with annealing.

scholarly journals Anodic Titanium Dioxide Nanotubes for Magnetically Guided Therapeutic Delivery

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Morteza Hasanzadeh Kafshgari ◽  
Delf Kah ◽  
Anca Mazare ◽  
Nhat Truong Nguyen ◽  
Monica Distaso ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Hela Cells ◽  
Release Kinetics ◽  
Drug Loading ◽  
Oxide Nanoparticles ◽  
Site Specific ◽  
Therapeutic Drugs ◽  
Wide Range

Abstract Hollow titanium dioxide (TiO2) nanotubes offer substantially higher drug loading capacity and slower drug release kinetics compared to solid drug nanocarriers of comparable size. In this report, we load TiO2 nanotubes with iron oxide nanoparticles to facilitate site-specific magnetic guidance and drug delivery. We generate magnetic TiO2 nanotubes (TiO2NTs) by incorporating a ferrofluid containing Ø ≈ 10 nm iron oxide nanoparticles in planar sheets of weakly connected TiO2 nanotubes. After thermal annealing, the magnetic tubular arrays are loaded with therapeutic drugs and then sonicated to separate the nanotubes. We demonstrate that magnetic TiO2NTs are non-toxic for HeLa cells at therapeutic concentrations (≤200 µg/mL). Adhesion and endocytosis of magnetic nanotubes to a layer of HeLa cells are increased in the presence of a magnetic gradient field. As a proof-of-concept, we load the nanotubes with the topoisomerase inhibitor camptothecin and achieve a 90% killing efficiency. We also load the nanotubes with oligonucleotides for cell transfection and achieve 100% cellular uptake efficiency. Our results demonstrate the potential of magnetic TiO2NTs for a wide range of biomedical applications, including site-specific delivery of therapeutic drugs.

Ultralong hydroxyapatite microtubes: solvothermal synthesis and application in drug loading and sustained drug release

CrystEngComm ◽  
2017 ◽  
Vol 19 (14) ◽  
pp. 1965-1973 ◽  
Author(s):  
Yong-Gang Zhang ◽  
Ying-Jie Zhu ◽  
Feng Chen ◽  
Tuan-Wei Sun ◽  
Ying-Ying Jiang
Keyword(s):  
Drug Release ◽  
Solvothermal Synthesis ◽  
Drug Loading ◽  
Sustained Drug Release

Solvothermal synthesis of tunable iron oxide nanorods and their transfer from organic phase to water phase

CrystEngComm ◽  
2014 ◽  
Vol 16 (4) ◽  
pp. 512-516 ◽  
Author(s):  
Jian-Chao Si ◽  
Yan Xing ◽  
Ming-Li Peng ◽  
Chao Zhang ◽  
Norbert Buske ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Organic Phase ◽  
Solvothermal Synthesis ◽  
Water Phase ◽  
Oxide Nanorods

scholarly journals IGF-1 Conjugated Sub-5 nm Ultrafine Iron Oxide Nanoparticle Enhances Targeted Drug Delivery and Efficacy of DNA Topoisomerase Inhibitor SN38 for Pancreatic Cancer: An in Vitro Study

2022 ◽  
Author(s):  
Peijia Xu ◽  
Ting Xue ◽  
Jonathan Padelford ◽  
Xingkui Xue ◽  
Alyssa Y Wu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Pancreatic Cancer ◽  
Iron Oxide ◽  
Drug Loading ◽  
Pancreatic Tumors ◽  
Iron Oxide Nanoparticle ◽  
Cell Targeting ◽  
Pancreatic Cancer Cells ◽  
Tumor Delivery ◽  
Oxide Nanoparticle

Abstract Background Pancreatic cancer remains one of the most lethal cancers largely due to the inefficient delivery of therapeutics. Nanomaterials have been extensively investigated as drug delivery platforms, showing improved drug pharmacodynamics and pharmacokinetics. However, their applications in pancreatic cancer have not yet been successful due to limited tumor delivery caused by dense tumor stroma and distorted tumor vasculatures. Meanwhile, smaller-sized nanomaterials have shown improved tumor delivery and retention in various tumors, including pancreatic tumors, suggesting their potential in enhancing drug delivery. Methods An ultrafine iron oxide nanoparticle (uIONP) was used to encapsulate 7-ethyl-10-hydroxyl camptothecin (SN38), the water-insoluble active metabolite of chemotherapy drug irinotecan for treating pancreatic cancer in clinic. Insulin-like growth factor 1 (IGF-1) was conjugated to uIONP as a ligand for targeting pancreatic cancer and stromal cells overexpressing IGF-1 receptor (IGF1R). The SN38 loading and release profile were characterized. The cancer cell targeting and induced apoptosis by developed nano-formulationIGF1-uIONP/SN38 were also investigated. Results IGF1-uIONP/SN38 demonstrated stable drug loading in physiological pH with the loading efficiency of 68.2 ± 3.5% (SN38/Fe, wt%) and <7% release for 24 hours. In tumor-interstitial- and lysosomal-mimicking pH (6.5 and 5.5), 52.2 and 91.3% of encapsulated SN38 were released over 24 hours. The IGF1-uIONP/SN38 exhibited specific receptor-mediated cell targeting and cytotoxicity to MiaPaCa-2 cells with IC50 of 11.8 ± 2.3 nM, but not to HEK293 human embryonic kidney cells. Conclusion The IGF1-uIONP significantly improved the delivery of SN38 to targeted pancreatic cancer cells, holding the potential for in vivo theranostic applications.

scholarly journals Lyophilized Iron Oxide Nanoparticles Encapsulated in Amphotericin B: A Novel Targeted Nano Drug Delivery System for the Treatment of Systemic Fungal Infections

Pharmaceutics ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 247
Author(s):  
Pavan Balabathula ◽  
Sarah Garland Whaley ◽  
Dileep R. Janagam ◽  
Nivesh K. Mittal ◽  
Bivash Mandal ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Drug Release ◽  
Amphotericin B ◽  
Iron Oxide Nanoparticles ◽  
Delivery System ◽  
Fungal Infections ◽  
Drug Loading ◽  
Laser Scanning Microscopy ◽  
Oxide Nanoparticles ◽  
Burst Release

We formulated and tested a targeted nanodrug delivery system to help treat life-threatening invasive fungal infections, such as cryptococcal meningitis. Various designs of iron oxide nanoparticles (IONP) (34–40 nm) coated with bovine serum albumin and coated and targeted with amphotericin B (AMB-IONP), were formulated by applying a layer-by-layer approach. The nanoparticles were monodispersed and spherical in shape, and the lead formulation was found to be in an optimum range for nanomedicine with size (≤36 nm), zeta potential (−20 mV), and poly dispersity index (≤0.2), and the drug loading was 13.6 ± 6.9 µg of AMB/mg of IONP. The drug release profile indicated a burst release of up to 3 h, followed by a sustained drug release of up to 72 h. The lead showed a time-dependent cellular uptake in C. albicans and C. glabrata clinical isolates, and exhibited an improved efficacy (16–25-fold) over a marketed conventional AMB-deoxycholate product in susceptibility testing. Intracellular trafficking of AMB-IONP by TEM and confocal laser scanning microscopy confirmed the successful delivery of the AMB payload at and/or inside the fungal cells leading to potential therapeutic advantages over the AMB-deoxycholate product. A short-term stability study at 5 °C and 25 °C for up to two months showed that the lyophilized form was stable.

Chitosan-polyglycidol complexes to coating iron oxide particles for dye adsorption

2020 ◽  
Vol 246 ◽  
pp. 116571
Author(s):  
Alina Iovescu ◽  
Gabriela Stîngă ◽  
Monica Elisabeta Maxim ◽  
Monika Gosecka ◽  
Teresa Basinska ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Dye Adsorption ◽  
Iron Oxide Particles ◽  
Oxide Particles

Superparamagnetic yolk–shell porous nanospheres of iron oxide@magnesium silicate: synthesis and application in high-performance anticancer drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (105) ◽  
pp. 103399-103411 ◽  
Author(s):  
Tuan-Wei Sun ◽  
Ying-Jie Zhu ◽  
Feng Chen ◽  
Chao Qi ◽  
Bing-Qiang Lu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Iron Oxide ◽  
High Performance ◽  
Drug Loading ◽  
Magnesium Silicate ◽  
Loading Capacity ◽  
Ph Responsive ◽  
High Drug ◽  
Anticancer Drug Delivery ◽  
High Drug Loading

The as-prepared yolk–shell porous nanospheres of SPIO@MS exhibit a high drug loading capacity, and a sustained and pH-responsive drug release behaviour.

Mannitol-assisted solvothermal synthesis of BiOCl hierarchical nanostructures and their mixed organic dye adsorption capacities

CrystEngComm ◽  
2014 ◽  
Vol 16 (20) ◽  
pp. 4298-4305 ◽  
Author(s):  
Fan Tian ◽  
Jinyan Xiong ◽  
Huiping Zhao ◽  
Yunling Liu ◽  
Shengqiang Xiao ◽  
...  
Keyword(s):  
Adsorption Capacity ◽  
Solvothermal Synthesis ◽  
Dye Removal ◽  
Dye Adsorption ◽  
Organic Dye ◽  
Solvothermal Process ◽  
Hierarchical Nanostructures ◽  
Adsorption Capacities

BiOCl hierarchical nanostructures have been successfully synthesized via a facile solvothermal process with the assistance of mannitol, and exhibited excellent adsorption capacity and favorable recycling ability for mixed organic dye removal.

scholarly journals Functional responsive superparamagnetic core/shell nanoparticles and their drug release properties

RSC Advances ◽  
2017 ◽  
Vol 7 (42) ◽  
pp. 26243-26249 ◽  
Author(s):  
Zied Ferjaoui ◽  
Raphaël Schneider ◽  
Abdelaziz Meftah ◽  
Eric Gaffet ◽  
Halima Alem
Keyword(s):  
Folic Acid ◽  
Iron Oxide ◽  
Drug Release ◽  
Drug Loading ◽  
Superparamagnetic Iron Oxide ◽  
Cancer Drug ◽  
Oxide Nanoparticles ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles

Folic acid functionalized responsive core/shell superparamagnetic iron oxide nanoparticles were successfully synthesized for further application in cancer therapy. Their cancer drug loading and release performances were demonstrated.

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