Development of a dual screening strategy to identify pro-angiogenic compounds from natural products: application on Tongmai Yangxin Pills

RSC Advances ◽  
2016 ◽  
Vol 6 (116) ◽  
pp. 115308-115316 ◽  
Author(s):  
Lailai Li ◽  
Ningning Liu ◽  
Xiangdong Dai ◽  
Haifeng Yan ◽  
Ling Zhang ◽  
...  
Keyword(s):  
Natural Products ◽  
Screening Strategy ◽  
First Time

Establishment and application the dual-screening strategy to screen pro-angiogenic compounds from natural products for the first time.

scholarly journals Antiproliferative Effects of Alkaloid Evodiamine and Its Derivatives

2018 ◽  
Vol 19 (11) ◽  
pp. 3403 ◽  
Author(s):  
Xu Hu ◽  
Dahong Li ◽  
Chun Chu ◽  
Xu Li ◽  
Xianhua Wang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Natural Products ◽  
Drug Administration ◽  
Antiproliferative Activity ◽  
Natural Source ◽  
Antiproliferative Effects ◽  
Anti Cancer ◽  
Ring Structures ◽  
First Time ◽  
Antiproliferative Activities

Alkaloids, a category of natural products with ring structures and nitrogen atoms, include most U.S. Food and Drug Administration approved plant derived anti-cancer agents. Evodiamine is an alkaloid with attractive multitargeting antiproliferative activity. Its high content in the natural source ensures its adequate supply on the market and guarantees further medicinal study. To the best of our knowledge, there is no systematic review about the antiproliferative effects of evodiamine derivatives. Therefore, in this article the review of the antiproliferative activities of evodiamine will be updated. More importantly, the antiproliferative activities of structurally modified new analogues of evodiamine will be summarized for the first time.

The First Occurrence in Nature of Two Compounds from Hops

2003 ◽  
Vol 58 (9-10) ◽  
pp. 640-642 ◽  
Author(s):  
Yan Qu ◽  
Zhi-Hui Ding ◽  
Ji-Kai Liu
Keyword(s):  
Natural Products ◽  
Humulus Lupulus ◽  
Spectral Evidence ◽  
First Occurrence ◽  
First Time

AbstractTwo compounds, (p-methoxyphenyl) diphenylmethanol (1) and tribenzylamine (2), were isolated from Humulus lupulus. Their structures were established on the basis of spectral evidence (MS, IR, NMR, HMBC, HMQC, 1H-1H COSY experiments). Compounds 1 and 2 were found as natural products at the first time.

Enantioselective first total syntheses of the antiviral natural products xiamycins D and E

2021 ◽  
Vol 57 (81) ◽  
pp. 10644-10646
Author(s):  
Dattatraya H. Dethe ◽  
Manmohan Shukla
Keyword(s):  
Natural Products ◽  
Total Syntheses ◽  
First Time

The enantioselective first total syntheses of marine pentacyclic indolosesquiterpenoids xiamycins D (4) and E (5) have been described for the first time to the best of our knowledge.

Chemical Constituents of the Lichen Cladina macaronesica

1991 ◽  
Vol 46 (1-2) ◽  
pp. 12-18 ◽  
Author(s):  
Antonio G . González ◽  
Jaime Bermejo Barrera ◽  
Elsa Ma Rodríguez Pérez ◽  
Consuelo E. Hernández Padrón
Keyword(s):  
Natural Products ◽  
Phenolic Compounds ◽  
Silver Nitrate ◽  
Silica Gel ◽  
Column Chromatography ◽  
Chemical Constituents ◽  
Usnic Acid ◽  
Acetone Extract ◽  
First Time

Column chromatography of the acetone extract of the lichen Cladina macaronesica (Sephadex LH-20, silica gel and silver nitrate-im pregnated silica gel) afforded eight triterpenes identified by chemical and spectral m eans. α-Amyrenone, lupenone, taraxerol, taraxerone and /so-arborinol acetate were isolated for the first time from lichens and (-)-usnic acid and five mononuclear phenolic compounds were also obtained, four for the first time as natural products. The possible transformation of perlatolic acid into these phenolic compounds is briefly outlined.

scholarly journals Mori Ramulus (Chin.Ph.)—the Dried Twigs of Morus alba L./Part 1: Discovery of Two Novel Coumarin Glycosides from the Anti-Hyperuricemic Ethanol Extract

Molecules ◽  
2019 ◽  
Vol 24 (3) ◽  
pp. 629
Author(s):  
Jianbiao Yao ◽  
Houhong He ◽  
Jin Xue ◽  
Jianfang Wang ◽  
Huihui Jin ◽  
...  
Keyword(s):  
Natural Products ◽  
Ethanol Extract ◽  
Accurate Method ◽  
Morus Alba ◽  
Strongly Correlated ◽  
Bioactive Constituents ◽  
Antiplatelet Aggregation ◽  
Pharmacologically Active ◽  
First Time ◽  
Tof Ms

In Traditional Chinese Medicine (TCM), Mori ramulus (Chin.Ph.)—the dried twigs of Morus alba L.—is extensively used as an antirheumatic agent and also finds additional use in asthma therapy. As a pathological high xanthine oxidase (XO, EC 1.1.3.22) activity is strongly correlated to hyperuricemy and gout, standard anti-hyperuremic therapy typically involves XO inhibitors like allopurinol, which often cause adverse effects by inhibiting other enzymes involved in purine metabolism. Mori ramulus may therefore be a promissing source for the development of new antirheumatic therapeutics with less side effects. Coumarins, one of the dominant groups of bioactive constituents of M. alba, have been demonstrated to possess anti-inflammatory, antiplatelet aggregation, antitumor, and acetylcholinesterase (AChE) inhibitory activities. The combination of HPLC (DAD) and Q-TOF technique could give excellent separating and good structural characterization abilities which make it suitable to analyze complex multi-herbal extracts in TCM. The aim of this study was to develop a HPLC (DAD)/ESI-Q-TOF-MS/MS method for the identification and profiling of pharmacologically active coumarin glycosides in Mori ramulus refined extracts for used in TCM. This HPLC (DAD)/ESI-Q-TOF-MS/MS method provided a rapid and accurate method for identification of coumarin glycosides—including new natural products described here for the first time—in the crude extract of M. alba L. In the course of this project, two novel natural products moriramulosid A (umbelliferone-6-β-d-apiofuranosyl-(1→6)-β-d-glucopyranoside) and moriramulosid B (6-[[6-O-(6-deoxy-α-l-mannopyranosyl)-β-d-glucopyranosyl]oxy]-2H-1-benzopyran-1-one) were newly discovered and the known natural product Scopolin was identified in M. alba L. for the first time.

scholarly journals Phytochemical Investigation and Anticonvulsant Activity of Paeonia parnassica Radix

2007 ◽  
Vol 2 (4) ◽  
pp. 1934578X0700200
Author(s):  
Marina Kritsanida ◽  
Prokopios Magiatis ◽  
Alexios-Leandros Skaltsounis ◽  
James P. Stables
Keyword(s):  
Natural Products ◽  
Spectral Data ◽  
Anticonvulsant Activity ◽  
Treatment Of Epilepsy ◽  
Phytochemical Investigation ◽  
First Time

Based on traditional reports of the use of plants of the genus Paeonia in the treatment of epilepsy, we have screened extracts of the roots of three Greek Paeonia species ( P. parnassica, P. mascula subsp. hellenica, P. clusii subsp. clusii) for anticonvulsant activity. This led to the identification of some interesting prophylactic anticonvulsant activity of the extracts of P. parnassica. From the roots of this species, seventeen compounds were subsequently isolated and identified. Amongst these, seven contained the characteristic cage-like terpenic skeleton that is found only in plants of the genus Paeonia. Two of the above products: 4- O-methylpaeoniflorin (1) and paeonidanin (2) are described for the first time as natural products. The structures of all compounds have been elucidated on the basis of their spectral data.

scholarly journals Triterpenoids and Sterols from the Stem of Alnus Formosana Burk

2006 ◽  
Vol 1 (4) ◽  
pp. 1934578X0600100 ◽  
Author(s):  
Chien-Kuang Chen ◽  
Shiou-Ling Tuh ◽  
Chung-Hsiung Chen ◽  
Chen-Meng Kuo ◽  
Shoei-Sheng Lee
Keyword(s):  
Natural Products ◽  
Betulinic Acid ◽  
Methanol Extract ◽  
Chemical Constituents ◽  
First Time ◽  
Soluble Fractions

The chemical constituents of the stem of Alnus formosana Burk. were investigated and sixteen known compounds, composed of eleven triterpenoids and five sterols, were isolated and characterized from the n-hexane- and chloroform-soluble fractions of the methanol extract. Of these, seven triterpenoids, lupeol, lupenone, betulinic acid, 3-O-acetylbetulinic acid, 3-O-acetylerythrodiol, 3-O-acetyloleanolic aldehyde, and taraxerone, were isolated for the first time from an Alnus species. The isolation of the five sterols, stigmastanone, stigmast-4-en-3-one, β-sitosterol, β-sitosteryl-β-D-glucoside, and stigmasta-3,6-dione, is also the first time that the presence of such natural products has been recorded for an Alnus species. Taraxerone and betulinic acid were the major non-polar constituents of the stem of A. formosana.

scholarly journals Bioactivity-Guided Purification of Novel Herbal Antioxidant and Anti-NO Compounds from Euonymus laxiflorus Champ.

Molecules ◽  
2018 ◽  
Vol 24 (1) ◽  
pp. 120 ◽  
Author(s):  
Van Nguyen ◽  
San-Lang Wang ◽  
Anh Nguyen ◽  
Zhi-Hu Lin ◽  
Chien Doan ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Natural Products ◽  
Biological Activities ◽  
The Novel ◽  
Health Food ◽  
Ic50 Values ◽  
Comparable Activity ◽  
New Compounds ◽  
First Time ◽  
Antidiabetic Effects

Euonymus laxiflorus Champ., a medicinal herb collected in Vietnam, has been reported to show several potent bioactivities, including anti-NO, enzyme inhibition, hypoglycemic and antidiabetic effects. Recently, the antioxidant activity of Euonymus laxiflorus Champ. trunk bark (ELCTB) has also been reported. However, the active antioxidant and anti-NO constituents existing in ELCTB have not been reported in the literature. The objective of this study was to purify the active antioxidants from ELCTB and investigate the anti-NO effect of the major constituents. Twenty-two phenolics isolated from ELCTB, including 12 compounds newly isolated in this study (1–12) and 10 constituents obtained from our previous work, were evaluated for their antioxidant activity. Of these, 12 compounds (4–6, 9, 13–15, 18–22) showed a potent antioxidant capacity (FRS50 = 7.8–58.11 µg/mL), in comparison to α-tocopherol (FRS50 = 23 µg/mL). In the anti-NO activity tests, Walterolactone A (1a) and B (1b) β-d-glucopyranoside (13) demonstrated the most effective and comparable activity to that of quercetin with max inhibition and IC50 values of 100%, 1.3 µg/mL, and 100%, 1.21 µg/mL, respectively. The crude extract and its major compounds showed no cytotoxicity on normal cells. Notably, three constituents (9, 11, and 12) were identified as new compounds, another three constituents, including 1, 7, and 8, were found to be new natural products, constituents 9 and 13 were determined to be new antioxidants, and compound 13 was reported to have novel potent anti-NO activity for the first time. The results of this study contribute to the enrichment of new natural products and compounds, as well as the novel biological activity of constituents isolated from Euonymus laxiflorus Champ. The current study also indicates ELCTB as a rich natural source of active phenolics. It is suggested that ELCTB could be developed as a health food with promising antioxidant and anti-NO effects, as well as other beneficial biological activities.

A Chemical Screening Strategy for the Dereplication and Prioritization of HIV-Inhibitory Aqueous Natural Products Extracts

1993 ◽  
Vol 56 (7) ◽  
pp. 1123-1129 ◽  
Author(s):  
John H. Cardellina ◽  
Murray H. G. Munro ◽  
Richard W. Fuller ◽  
Kirk P. Manfredi ◽  
Tawnya C. McKee ◽  
...  
Keyword(s):  
Natural Products ◽  
Screening Strategy ◽  
Chemical Screening

Naturally occurring organoiodines

RSC Advances ◽  
2014 ◽  
Vol 4 (101) ◽  
pp. 57350-57376 ◽  
Author(s):  
Lishu Wang ◽  
Xuefeng Zhou ◽  
Mangaladoss Fredimoses ◽  
Shengrong Liao ◽  
Yonghong Liu
Keyword(s):  
Natural Products ◽  
The Past ◽  
Naturally Occurring ◽  
First Time

This review, with 290 references, presents the fascinating area of iodinated natural products over the past hundred years for the first time.

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