Shikonin derivatives as inhibitors of tyrosyl-tRNA synthetase: design, synthesis and biological evaluation

RSC Advances ◽  
2016 ◽  
Vol 6 (86) ◽  
pp. 83003-83010 ◽  
Author(s):  
Han-Yue Qiu ◽  
Peng-Fei Wang ◽  
Zi-Zhen Wang ◽  
Yue-Lin Luo ◽  
Dong-Qing Hu ◽  
...  
Keyword(s):  
Natural Product ◽  
In Silico ◽  
Biological Evaluation ◽  
Trna Synthetase ◽  
Design Synthesis ◽  
Shikonin Derivatives ◽  
Synthesis And Biological Evaluation

A series of novel tyrosyl-tRNA synthetase inhibitors was designed and synthesized as anti-bacteria agents based on natural product shikonin and in silico scaffold modification strategy.

scholarly journals Fishing Anti-Inflammatories from Known Drugs: In Silico Repurposing, Design, Synthesis and Biological Evaluation of Bisacodyl Analogues

2017 ◽  
Vol 17 (25) ◽  
Author(s):  
Maite Sylla-Iyarreta Veitia ◽  
Dany Siverio Mota ◽  
Vanessa Lerari ◽  
Marta Marin ◽  
Rosa M. Giner ◽  
...  
Keyword(s):  
In Silico ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

Metronidazole containing pyrazole derivatives potently inhibit tyrosyl-tRNA synthetase: design, synthesis, and biological evaluation

2016 ◽  
Vol 88 (4) ◽  
pp. 592-598 ◽  
Author(s):  
Long-Wang Chen ◽  
Peng-Fei Wang ◽  
Dan-Jie Tang ◽  
Xiang-Xiang Tao ◽  
Ruo-Jun Man ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Trna Synthetase ◽  
Pyrazole Derivatives ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

scholarly journals Design, synthesis, and biological evaluation of a new class of benzo[b ]furan derivatives as antiproliferative agents, with in silico predicted antitubulin activity

2017 ◽  
Vol 91 (1) ◽  
pp. 39-49 ◽  
Author(s):  
Antonino Lauria ◽  
Carla Gentile ◽  
Francesco Mingoia ◽  
Antonio Palumbo Piccionello ◽  
Roberta Bartolotta ◽  
...  
Keyword(s):  
In Silico ◽  
Biological Evaluation ◽  
Furan Derivatives ◽  
Design Synthesis ◽  
Antiproliferative Agents ◽  
New Class ◽  
Synthesis And Biological Evaluation
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