Microwave-assisted synthesis of chitooligosaccharide guanidine and its effect on GLUT4-dependent glucose uptake through an Akt-activated protein kinase signaling pathway in L6 skeletal muscle cells

RSC Advances ◽  
2016 ◽  
Vol 6 (93) ◽  
pp. 90777-90785 ◽  
Author(s):  
Li Wang ◽  
Zongbao Liu ◽  
Xiaofei Liu ◽  
Yuntang Wu
Keyword(s):  
Skeletal Muscle ◽  
Protein Kinase ◽  
Glucose Uptake ◽  
Signaling Pathway ◽  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
Phosphorylation Level ◽  
Protein Kinase Signaling ◽  
Kinase Signaling Pathway ◽  
L6 Skeletal Muscle Cells

COSG was likely to be effective by increasing the phosphorylation level of Akt and promoting the membrane translocation of GLUT4, thereby increasing the glucose uptake of skeletal cells.

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