Injectable and self-healing dynamic hydrogel containing bioactive glass nanoparticles as a potential biomaterial for bone regeneration

RSC Advances ◽  
2016 ◽  
Vol 6 (73) ◽  
pp. 69156-69166 ◽  
Author(s):  
Ana Gantar ◽  
Nataša Drnovšek ◽  
Pablo Casuso ◽  
Adrián Pérez-San Vicente ◽  
Javier Rodriguez ◽  
...  

Combination of Au-based dynamic hydrogel with 100 nm bioactive glass nanoparticles resulted in the formation of an injectable, self-healing and biocompatible hydrogel nanocomposites with osteoinductive properties and potential for bone regeneration.

2021 ◽  
Vol 557 ◽  
pp. 120628
Author(s):  
Silmara C. Santos ◽  
Katharina G. Spaniol ◽  
Nikolas E. Chaves-Silva ◽  
Roberta P.M. Fernandes ◽  
Débora S. Tavares ◽  
...  

2012 ◽  
Vol 6 (4) ◽  
pp. 470-483 ◽  
Author(s):  
Lijun Ji ◽  
Yunfeng Si ◽  
Ailing Li ◽  
Wenjun Wang ◽  
Dong Qiu ◽  
...  

2021 ◽  
Vol 9 (5) ◽  
pp. 630-638
Author(s):  
Fatema Aziz Al-Sayed ◽  
◽  
Radwa Hamed Hegazy ◽  
Zeinab Amin Salem ◽  
Hanan Hassan El-Beheiry ◽  
...  

An ideal biomaterial for bone regeneration is a longstanding quest nowadays. This study aimed to evaluate the osteogenic potentiality of nano-bioactive glass enhanced biocement based silicate with or without hyaluronic acid seeded in rabbits’ tibial bone defects. For this, 24 male rabbits with two 5 mm defects (1 defect per tibia) were divided into three equal groups. Among the predefined three groups, for the rabbits of group 1(control) bone defects were left untreated while for the members of group 2 defects received nano-bioactive glass enhanced biocement based silicate cement, and group 3 defects received nano-bioactive glass cement mixed with hyaluronic acid. Animals of each group were divided equally for euthanization after 3 and 6 weeks. Bone specimens were processed and examined histologically with histomorphometrically analysis of new bone area percentage. The bone defects in group 3 showed significantly improved osseous healing histologically as compared to the group 1&2. The morphometric analysis also revealed a significant increase in the new bone area percentage in group 3 as compared to the group 1 and 2 (P < 0.05). The results of the present study can be concluded that bone defects could be treated with nano-bioactive glass and hyaluronic acid cement. Although, nano-bioactive glass alone was capable of bone regeneration the combination of both had significant regenerative capacity.


2013 ◽  
Vol 33 (7) ◽  
pp. 4203-4212 ◽  
Author(s):  
John A. Killion ◽  
Sharon Kehoe ◽  
Luke M. Geever ◽  
Declan M. Devine ◽  
Eoin Sheehan ◽  
...  

RSC Advances ◽  
2020 ◽  
Vol 10 (36) ◽  
pp. 21413-21419 ◽  
Author(s):  
Muhammad Saif Ur Rahman ◽  
Muhammad Asif Tahir ◽  
Saima Noreen ◽  
Muhammad Yasir ◽  
Ijaz Ahmad ◽  
...  

A combination of chemotherapy with hyperthermia can produce remarkable success in treating advanced cancers.


2019 ◽  
Vol 90 ◽  
pp. 393-402 ◽  
Author(s):  
N. Gómez-Cerezo ◽  
L. Casarrubios ◽  
M. Saiz-Pardo ◽  
L. Ortega ◽  
D. de Pablo ◽  
...  

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