Rigid versus flexible anilines or anilides confirm the bicyclic ring as the hydrophobic portion for optimal σ2 receptor binding and provide novel tools for the development of future σ2 receptor PET radiotracers

Mauro Niso; Maria Laura Pati; Francesco Berardi; Carmen Abate

doi:10.1039/c6ra15783a

Rigid versus flexible anilines or anilides confirm the bicyclic ring as the hydrophobic portion for optimal σ2 receptor binding and provide novel tools for the development of future σ2 receptor PET radiotracers

RSC Advances ◽

10.1039/c6ra15783a ◽

2016 ◽

Vol 6 (91) ◽

pp. 88508-88518 ◽

Cited By ~ 6

Author(s):

Mauro Niso ◽

Maria Laura Pati ◽

Francesco Berardi ◽

Carmen Abate

Keyword(s):

Receptor Binding ◽

Tumor Diseases ◽

Pet Radiotracers ◽

Hydrophobic Portion

Despite their uncertain identification, σ2 receptors are promising targets for the development of diagnostics and therapeutics for tumor diseases.

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Effect of cerebral hypoxia on NMDA receptor binding characteristics after treatment with 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) in newborn piglets

Brain Research ◽

10.1016/s0006-8993(96)00232-6 ◽

1996 ◽

Vol 729 (1) ◽

pp. 66-74

Author(s):

K Fritz

Keyword(s):

Nmda Receptor ◽

Receptor Binding ◽

Phosphonic Acid ◽

Cerebral Hypoxia ◽

Binding Characteristics ◽

Newborn Piglets ◽

Nmda Receptor Binding

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Calcitonin Gene-Related Peptide (CGRP) receptor binding and localization in nonpregnant and pregnant rat uterus and regulation by sex steroid hormones

Journal of the Society for Gynecologic Investigation ◽

10.1016/s1071-5576(97)86210-7 ◽

1998 ◽

Vol 5 (1) ◽

pp. 73A-73A ◽

Cited By ~ 1

Author(s):

C YALLAMPALLI ◽

P GANGULA ◽

Y DONG ◽

L FANG ◽

S WIMALAWANSA

Keyword(s):

Steroid Hormones ◽

Receptor Binding ◽

Calcitonin Gene Related Peptide ◽

Sex Steroid Hormones ◽

Sex Steroid ◽

Cgrp Receptor ◽

Rat Uterus ◽

Pregnant Rat ◽

Related Peptide ◽

Calcitonin Gene

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Effect of amphetamine on dopamine D2 receptor binding in the primate brain with the agonist ligand [11C]MNPA

Journal of Cerebral Blood Flow & Metabolism ◽

10.1038/sj.jcbfm.9591524.0646 ◽

2005 ◽

Vol 25 (1_suppl) ◽

pp. S646-S646

Author(s):

Nicholas Seneca ◽

Sjoerd Finnema ◽

Masanori Ichise ◽

Balazs Gulyas ◽

Håkan Wikstrom ◽

...

Keyword(s):

Receptor Binding ◽

Dopamine D2 Receptor ◽

D2 Receptor ◽

Dopamine D2 ◽

Primate Brain

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Antiproliferative and antiviral effects of mutated IFN-alpha with increased IFN receptor binding affinity

Zeitschrift für Gastroenterologie ◽

10.1055/s-0030-1269699 ◽

2011 ◽

Vol 49 (01) ◽

Author(s):

MF Sprinzl ◽

L Bührer ◽

D Strand ◽

G Schreiber ◽

PR Galle ◽

...

Keyword(s):

Binding Affinity ◽

Receptor Binding ◽

Receptor Binding Affinity ◽

Ifn Alpha ◽

Antiviral Effects

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Decreased Dopamine D2/D3-Receptor Binding in the Temporal Lobe and the Bilateral Basal Ganglia in patients with Temporal Lobe Epilepsy

Klinische Neurophysiologie ◽

10.1055/s-0032-1301572 ◽

2012 ◽

Vol 43 (01) ◽

Author(s):

VE Bernedo Paredes ◽

H Schwartz ◽

M Gartenschläger ◽

HG Buchholz ◽

...

Keyword(s):

Basal Ganglia ◽

Temporal Lobe Epilepsy ◽

Temporal Lobe ◽

Receptor Binding ◽

D3 Receptor ◽

Dopamine D2

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Vergleich von Blutfluß und Benzodiazepin-Rezeptorverteilung bei fokaler Epilepsie: Vorläufige Ergebnisse einer SPECT-Studie

Nuklearmedizin ◽

10.1055/s-0038-1629489 ◽

1989 ◽

Vol 28 (05) ◽

pp. 181-186

Author(s):

A. Ludolph ◽

O. Schober ◽

G. Lottes ◽

I. Böttger ◽

H.-F. Beer ◽

...

Keyword(s):

Human Brain ◽

Receptor Binding ◽

Brain Area ◽

Brain Perfusion ◽

Partial Epilepsy ◽

Cerebral Lesion ◽

Receptor Ligand ◽

Receptor Mapping ◽

Hmpao Spect ◽

99Mtc Hmpao

99mTc-HMPAO-SPECT and SPECT with the 123I-labelled benzodiazepine (Bz) receptor ligand Ro 16-0154 were performed in 10 patients suffering from partial epilepsy, without cerebral lesion in MRT or CT. 2 h p.i. of Ro 16-0154 the distribution of activity correlated with the known distribution of Bz- receptors in the human brain. Perfusion and receptor-binding were found decreased in 7 patients of each study in the suspicious brain-area. 123l-labelled Ro 16-0154 is suitable for Bz-receptor mapping by SPECT. The decrease of Bz-receptor binding in epileptic foci, as described in PET-studies, was also detected by SPECT in 7 of 10 patients.

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Stellenwert der Navigation

Die Wirbelsäule ◽

10.1055/s-0043-112422 ◽

2017 ◽

Vol 01 (04) ◽

pp. 317-334

Author(s):

Jan-Sven Jarvers ◽

Ulrich Spiegl ◽

Stefan Glasmacher ◽

Christoph Heyde ◽

Christoph Josten

Keyword(s):

Patient Safety ◽

Radiation Exposure ◽

Pedicle Screw ◽

Spinal Surgery ◽

Intraoperative Imaging ◽

Intraoperative Navigation ◽

Advantages And Disadvantages ◽

Tumor Diseases ◽

Intraoperative Control ◽

Improved Technology

Abstract Importance of Navigation Navigation and intraoperative imaging have undergone an enormous development in recent years. By using intraoperative navigation, the precision of pedicle screw implantation can be increased in the sense of patient safety. Especially in the case of complex defects or tumor diseases, navigation is a decisive aid. As a result of the constantly improved technology, the requirements for reduced radiation exposure and intraoperative control can also be met. The high costs of the devices can be amortized, for example by a reduced number of revisions. This overview presents the principles of navigation in spinal surgery and the advantages and disadvantages of the different navigation procedures.

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