Convenient one-step synthesis of pyrrolo[3,4-c]quinolin-1-ones via TMSCl-catalyzed cascade reactions of isatins and β-enamino ketones

RSC Advances ◽  
2016 ◽  
Vol 6 (77) ◽  
pp. 73760-73768 ◽  
Author(s):  
Hui Xu ◽  
Pan Zhou ◽  
Bei Zhou ◽  
Jie Zhou ◽  
Yuehai Shen ◽  
...  
Keyword(s):  
Cascade Reactions ◽  
Enamino Ketones ◽  
Mild Conditions ◽  
One Step ◽  
High Yields

A series of pyrrolo[3,4-c]quinolin-1-ones were afforded by TMSCl-catalyzed isatins and β-enamino ketones in high yields under mild conditions.

Divergent Synthesis of Five-Membered Nitrogen Heterocycles via Cascade Reactions of 4-Arylfuroxans

Synthesis ◽  
2020 ◽  
Vol 52 (18) ◽  
pp. 2667-2678
Author(s):  
Leonid L. Fershtat ◽  
Daniil A. Chaplygin ◽  
Ivan V. Ananyev ◽  
Nina N. Makhova
Keyword(s):  
Ring Opening ◽  
Heterocyclic Compounds ◽  
Nitrogen Heterocycles ◽  
Cascade Reactions ◽  
Materials Chemistry ◽  
One Pot ◽  
Mild Conditions ◽  
Novel Method ◽  
High Yields

A novel method for the synthesis of a diverse series of functionally substituted five-membered heterocyclic compounds via atom-economic, regio-, and diastereoselective one-pot reaction cascade was developed. This approach involves a ring opening in 4-arylfuroxans to α-oximinoarylacetonitrile oxides followed by [3+2] cycloaddition to various dipolarophiles to afford multisubstituted isoxazoles and isoxazolines. Subsequent azole–azole rearrangement of (oximino)isoxazolines/-isoxazoles, which can be conducted in a one-pot manner, results into functionally substituted furazans formation. The developed protocol is operationally simple, proceeds in mild conditions and with high yields of target heterocyclic systems. Overall, this study represents a new mode of isoxazole and 1,2,5-oxadiazole functionalization strategy, which is useful in medicinal and materials chemistry.

An Efficient Direct Access to Carbamates from Alcohols and TosMIC Mediated by Iodine in DMSO

Synlett ◽  
2018 ◽  
Vol 29 (15) ◽  
pp. 2039-2042 ◽  
Author(s):  
Y. Prapurna ◽  
Naresh Pogaku ◽  
Palakodety Krishna
Keyword(s):  
Direct Access ◽  
New Approach ◽  
Mild Conditions ◽  
Rapid Construction ◽  
Practical Strategy ◽  
Dmso System ◽  
Reaction Proceeds ◽  
One Step ◽  
High Yields

A new approach for the synthesis of carbamates from alcohols and TosMIC promoted by iodine/DMSO system is reported. This method offers a one-step, direct and practical strategy for the rapid construction of carbamates under mild conditions. The reaction proceeds via sequential oxidation of isocyanide to isocyanate and nucleo­philic addition of alcohols to isocyanate to afford the carbamates in high yields.

One-step fabrication of Pd-embedded hierarchically porous carbon micro-spheres for formaldehyde removal under mild conditions

2021 ◽  
Author(s):  
Zhigang Ren ◽  
peng zhao ◽  
Ye Zhang ◽  
Yang Yu ◽  
xiaoxuan lv ◽  
...  
Keyword(s):  
Porous Carbon ◽  
Carbon Microspheres ◽  
Carbon Spheres ◽  
Pickering Emulsions ◽  
Hierarchically Porous ◽  
Mild Conditions ◽  
Formaldehyde Removal ◽  
One Step

Micron-sized carbon spheres synthesized via pickering emulsions has attracted much attention in recent two years. In present paper, we prepared palladium (Pd) and nitrogen co-embedded carbon microspheres for formaldehyde (HCHO)...

scholarly journals Electrochemical multicomponent synthesis of 4-selanylpyrazoles under catalyst- and chemical-oxidant-free conditions

2021 ◽  
Author(s):  
Yan Wu ◽  
Jin-Yang Chen ◽  
Jing Ning ◽  
Xue Jiang ◽  
Jie Deng ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Raw Materials ◽  
Multicomponent Synthesis ◽  
Mild Conditions ◽  
Simple Protocol ◽  
High Yields

An electrochemical multicomponent reaction was established under catalyst-, chemical-oxidant-free and mild conditions, which provides an eco-friendly and simple protocol for constructing 4-selanylpyrazoles from easily available raw materials with high yields.

scholarly journals Synthesis of bifunctional nanocatalyst from waste palm kernel shell and its application for biodiesel production

RSC Advances ◽  
2020 ◽  
Vol 10 (45) ◽  
pp. 27183-27193
Author(s):  
Rose Fadzilah Abdullah ◽  
Umer Rashid ◽  
Yun Hin Taufiq-Yap ◽  
Mohd Lokman Ibrahim ◽  
Chawalit Ngamcharussrivichai ◽  
...  
Keyword(s):  
Palm Kernel ◽  
Biodiesel Production ◽  
Palm Kernel Shell ◽  
Mild Conditions ◽  
One Step

The potential of bifunctional nanocatalysts obtained from waste palm kernel shell (PKS) was investigated for one-step transesterification–esterification under mild conditions.

scholarly journals PEG-embedded KBr3: A recyclable catalyst for multicomponent coupling reaction for the efficient synthesis of functionalized piperidines

2011 ◽  
Vol 7 ◽  
pp. 1334-1341 ◽  
Author(s):  
Sanny Verma ◽  
Suman L Jain ◽  
Bir Sain
Keyword(s):  
Coupling Reaction ◽  
Recyclable Catalyst ◽  
Efficient Synthesis ◽  
Molecular Bromine ◽  
Keto Ester ◽  
One Step ◽  
High Yields ◽  
Multicomponent Coupling ◽  
Three Component Coupling

PEG-embedded potassium tribromide ([K+PEG]Br3 −) was found to be an efficient and recyclable catalyst for the synthesis of functionalized piperidines in high yields in a one step, three component coupling between aldehyde, amine and β-keto ester. At the end of the reaction the [K+PEG]Br3 − was readily regenerated from the reaction mixture by treating the residue containing [K+PEG]Br− with molecular bromine.

Production of novel carbon nanostructures by electrochemical reduction of polychlorinated organic rings under mild conditions for supercapacitors

2021 ◽  
Author(s):  
Züleyha Kudaş ◽  
Emir Çepni ◽  
Emre Gür ◽  
Duygu Ekinci
Keyword(s):  
Carbon Source ◽  
Electrochemical Reduction ◽  
Electrochemical Method ◽  
Carbon Nanostructures ◽  
Electrochemical Growth ◽  
Mild Conditions ◽  
One Step ◽  
The One ◽  
Carbon Based

Here, new carbon-based nanostructures were prepared by the one-step electrochemical method using hexagonal and pentagonal polychlorinated organic rings as carbon source. The electrochemical growth of carbon nanostructures on substrates was...

scholarly journals Amphiphilic Biaryl Monophosphine Ligands by Regioselective Sulfonation

2020 ◽  
Author(s):  
Jacob Rodriguez ◽  
Heemal Dhanjee ◽  
Stephen L. Buchwald
Keyword(s):  
Sulfuric Acid ◽  
Chromatographic Purification ◽  
Organometallic Reactions ◽  
One Step ◽  
High Yields

<div> <p>Amphiphilic ligands are valued for their ability to facilitate organometallic reactions in the presence of water. The regioselective sulfonation of a series of commercially available biaryl monophosphines to generate amphiphilic ligands is presented. In this one-step protocol, the temperature and addition of fuming sulfuric acid were carefully controlled to arrive at sulfonated biaryl monophosphine ligands in high yields with >95% regioselectivity without the need for chromatographic purification.</p> </div>

scholarly journals Three-component synthesis of highly functionalized aziridines containing a peptide side chain and their one-step transformation into β-functionalized α-ketoamides

2016 ◽  
Vol 12 ◽  
pp. 1772-1777 ◽  
Author(s):  
Lena Huck ◽  
Juan F González ◽  
Elena de la Cuesta ◽  
J Carlos Menéndez
Keyword(s):  
Single Step ◽  
Side Chain ◽  
One Pot ◽  
Aziridine Ring ◽  
Component Process ◽  
Mild Conditions ◽  
One Step

A sequential three-component process is described, starting from 3-arylmethylene-2,5-piperazinediones and involving a one-pot sequence of reactions achieving regioselective opening of the 2,5-diketopiperazine ring and diastereoselective generation of an aziridine ring. This method allows the preparation of N-unprotected, trisubstituted aziridines bearing a peptide side chain under mild conditions. Their transformation into β-trifluoroacetamido-α-ketoamide and α,β-diketoamide frameworks was also achieved in a single step.

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