Janus particle synthesis via aligned non-concentric angular nozzles and electrohydrodynamic co-flow for tunable drug release

RSC Advances ◽  
2016 ◽  
Vol 6 (81) ◽  
pp. 77174-77178 ◽  
Author(s):  
Chunchen Zhang ◽  
Ming-Wei Chang ◽  
Yudong Li ◽  
Yuankai Qi ◽  
Jingwen Wu ◽  
...  
Keyword(s):  
Drug Release ◽  
Processing Parameters ◽  
Janus Particles ◽  
Particle Structure ◽  
Janus Particle ◽  
Particle Synthesis ◽  
Tilted Angle ◽  
Dual Drug

A novel non-concentric tilted angle nozzle was designed and manufactured to enable the synthesis of tunable Janus particles. The effect of processing parameters and device configurations on particle structure and dual drug release were explored.

scholarly journals Chitosan/Silver Nanoparticle/Graphene Oxide Nanocomposites with Multi-Drug Release, Antimicrobial, and Photothermal Conversion Functions

Materials ◽  
2021 ◽  
Vol 14 (9) ◽  
pp. 2351
Author(s):  
Zheng Su ◽  
Daye Sun ◽  
Li Zhang ◽  
Miaomiao He ◽  
Yulin Jiang ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Graphene Oxide ◽  
Drug Release ◽  
Release Rate ◽  
Composite System ◽  
Methyl Blue ◽  
Burst Release ◽  
Fluorescein Sodium ◽  
Photothermal Conversion ◽  
Dual Drug

In this work, we designed and fabricated a multifunctional nanocomposite system that consists of chitosan, raspberry-like silver nanoparticles, and graphene oxide. The room temperature atmospheric pressure microplasma (RT-APM) process provides a rapid, facile, and environmentally-friendly method for introducing silver nanoparticles into the composite system. Our composite can achieve a pH controlled single and/or dual drug release. Under pH 7.4 for methyl blue loaded on chitosan, the drug release profile features a burst release during the first 10 h, followed by a more stabilized release of 70–80% after 40–50 h. For fluorescein sodium loaded on graphene oxide, the drug release only reached 45% towards the end of 240 h. When the composite acted as a dual drug release system, the interaction of fluorescein sodium and methyl blue slowed down the methyl blue release rate. Under pH 4, both single and dual drug systems showed a much higher release rate. In addition, our composite system demonstrated strong antibacterial abilities against E. coli and S. aureus, as well as an excellent photothermal conversion effect under irradiation of near infrared lasers. The photothermal conversion efficiency can be controlled by the laser power. These unique functionalities of our nanocomposite point to its potential application in multiple areas, such as multimodal therapeutics in healthcare, water treatment, and anti-microbials, among others.

Wireless Electrografting of Molecular Layers for Janus Particle Synthesis

2012 ◽  
Vol 19 (5) ◽  
pp. 1577-1580 ◽  
Author(s):  
Chawanwit Kumsapaya ◽  
Marie-France Bakaï ◽  
Gabriel Loget ◽  
Bertrand Goudeau ◽  
Chompunuch Warakulwit ◽  
...  
Keyword(s):  
Janus Particle ◽  
Particle Synthesis ◽  
Molecular Layers

scholarly journals Chitosan/Silver Nanoparticle/Graphene Oxide Nanocomposites with Multi-drug Release, Antimicrobial, and Photothermal Conversion Functions

2021 ◽  
Author(s):  
Zheng Su ◽  
Daye Sun ◽  
Li Zhang ◽  
Miaomiao He ◽  
Yulin Jiang ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Graphene Oxide ◽  
Drug Release ◽  
Composite System ◽  
Near Infrared ◽  
Environment Friendly ◽  
Photothermal Conversion ◽  
E Coli ◽  
Nanocomposite System ◽  
Dual Drug

In this work, we designed and fabricated a multifunctional nanocomposite system which consists of chitosan, raspberry-like silver nanoparticles and graphene oxide. Room temperature atmospheric pressure microplasma (RT-APM) process provides a rapid, facile, and environment-friendly method for introducing silver nanoparticles into the composite system. By loading different drugs onto the polymer matrix and/or graphene oxide, our composite can achieve a pH controlled dual drug release with release profile specific to the drugs used. In addition to its strong antibacterial ability against E. coli and S. aureus, our composite also demonstrates excellent photothermal conversion effect under irradiation of near infrared lasers. These unique functionalities point to it’s the potential of nanocomposite system in multiple applications areas such as multimodal therapeutics in healthcare, water treatment, and anti-microbial, etc.

scholarly journals Dual-Drug-Loaded Silk Fibroin/PLGA Scaffolds for Potential Bone Regeneration Applications

2019 ◽  
Vol 2019 ◽  
pp. 1-16 ◽  
Author(s):  
Jihang Yao ◽  
Yilong Wang ◽  
Wendi Ma ◽  
Wenying Dong ◽  
Mei Zhang ◽  
...  
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Bone Regeneration ◽  
Silk Fibroin ◽  
Bone Morphogenetic Protein 2 ◽  
Burst Release ◽  
Nanofiber Membrane ◽  
Differentiation Potential ◽  
Dual Drug

Developing scaffold materials with excellent biocompatibility, mechanical properties, and controlled drug release properties is vital to tissue engineering. In this study, we fabricated silk fibroin (SF)/poly(lactide-co-glycolide) (PLGA) nanofiber scaffolds containing recombinant human bone morphogenetic protein 2 (rhBMP2) and dexamethasone (DXM) via coaxial electrospinning, which were used in in vitro bone formation with rat bone marrow mesenchymal stem cells (rBMSCs). An in vitro drug release study was adopted to evaluate the sustained release potential of the core-shell structured nanofibers. Furthermore, we detected the potential of the SF/PLGA nanofiber membrane in vitro. In vitro studies showed that rhBMP2 still remained active on the nanofiber membrane. In addition, the dual-drug-loaded nanofiber membrane showed an early burst release of DXM and late sustained release of rhBMP2. rhBMP2 and DXM exhibited strong osteogenic differentiation potential when they acted on rBMSCs. Therefore, the SF/PLGA nanofiber membrane loaded with rhBMP2 and DXM has great potential for the enhancement of bone regeneration.

scholarly journals Programmed assembly of oppositely charged homogeneously decorated and Janus particles

2016 ◽  
Vol 191 ◽  
pp. 89-104 ◽  
Author(s):  
Alina Kirillova ◽  
Georgi Stoychev ◽  
Alla Synytska
Keyword(s):  
Optical Properties ◽  
Electrostatic Interactions ◽  
Building Blocks ◽  
Janus Particles ◽  
Complex Structures ◽  
Janus Particle ◽  
Micro Structures ◽  
Oppositely Charged ◽  
Particle Assemblies ◽  
Programmed Assembly

The exploitation of colloidal building blocks with morphological and functional anisotropy facilitates the generation of complex structures with unique properties, which are not exhibited by isotropic particle assemblies. Herein, we demonstrate an easy and scalable bottom-up approach for the programmed assembly of hairy oppositely charged homogeneously decorated and Janus particles based on electrostatic interactions mediated by polyelectrolytes grafted onto their surface. Two different assembly routes are proposed depending on the target structures: raspberry-like/half-raspberry-like or dumbbell-like micro-clusters. Ultimately, stable symmetric and asymmetric micro-structures could be obtained in a well-controlled manner for the homogeneous–homogeneous and homogeneous–Janus particle assemblies, respectively. The spatially separated functionalities of the asymmetric Janus particle-based micro-clusters allow their further assembly into complex hierarchical constructs, which may potentially lead to the design of materials with tailored plasmonics and optical properties.

Study in the experimental manipulation of Janus particle synthesis via emulsion-based method

2020 ◽  
Vol 603 ◽  
pp. 125183
Author(s):  
Zhenxin Chu ◽  
Bin Zhong ◽  
Wanrong Zhou ◽  
Pengcheng Cui ◽  
Jiale Gu ◽  
...  
Keyword(s):  
Experimental Manipulation ◽  
Janus Particle ◽  
Particle Synthesis
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