Integration of poly(3-hexylthiophene) conductive stripe patterns with 3D tubular structures for tissue engineering applications

RSC Advances ◽  
2016 ◽  
Vol 6 (76) ◽  
pp. 72519-72524 ◽  
Author(s):  
Yingjuan Sun ◽  
Hongyan Li ◽  
Yuan Lin ◽  
Li Niu ◽  
Qian Wang
Keyword(s):  
Tissue Engineering ◽  
Self Assembly ◽  
Large Scale ◽  
Cell Alignment ◽  
Tubular Structures ◽  
Engineering Applications ◽  
Cellular Behaviors ◽  
Self Assembled ◽  
Electric Signals

P3HT was self-assembled into large-scale conductive stripe patterns based on confined evaporative self-assembly. These conductive stripe patterns could induce cell alignment and provide spatial electric signals to modulate cellular behaviors.

Self-Assembled Biomimetic Scaffolds for Bone Tissue Engineering

2016 ◽  
pp. 104-132
Author(s):  
Ozan Karaman ◽  
Cenk Celik ◽  
Aylin Sendemir Urkmez
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Donor Site ◽  
Donor Site Morbidity ◽  
Engineering Applications ◽  
Temporal Regulation ◽  
Biomimetic Scaffolds ◽  
Self Assembled

Cranial, maxillofacial, and oral fractures, as well as large bone defects, are currently being treated by auto- and allograft procedures. These techniques have limitations such as immune response, donor-site morbidity, and lack of availability. Therefore, the interest in tissue engineering applications as replacement for bone graft has been growing rapidly. Typical bone tissue engineering models require a cell-supporting scaffold in order to maintain a 3-dimensional substrate mimicking in vivo extracellular matrix for cells to attach, proliferate and function during the formation of bone tissue. Combining the understanding of molecular and structural biology with materials engineering and design will enable new strategies for developing biological tissue constructs with clinical relevance. Self-assembled biomimetic scaffolds are especially suitable as they provide spatial and temporal regulation. Specifically, self-assembling peptides capable of in situ gelation serve as attractive candidates for minimally invasive injectable therapies in bone tissue engineering applications.

Nanowire-assisted self-assembly of one-dimensional nanocrystal superlattice chains

2019 ◽  
Vol 7 (27) ◽  
pp. 8471-8476 ◽  
Author(s):  
Yongqiang Ji ◽  
Minqiang Wang ◽  
Zhi Yang ◽  
Shangdong Ji ◽  
Hengwei Qiu
Keyword(s):  
Self Assembly ◽  
Large Scale ◽  
One Dimensional ◽  
Self Assembled

Ordered and self-assembled nanocrystal superstructures have attracted intense attention due to their ability to transfer unique nanoscale properties to large scale.

scholarly journals Development of Synthetic and Natural Materials for Tissue Engineering Applications Using Adipose Stem Cells

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Yunfan He ◽  
Feng Lu
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Tissue Regeneration ◽  
Large Scale ◽  
Clinical Applications ◽  
Adipose Stem Cells ◽  
Laboratory Research ◽  
Engineering Applications ◽  
Plastic And Reconstructive Surgery ◽  
Relative Ease

Adipose stem cells have prominent implications in tissue regeneration due to their abundance and relative ease of harvest from adipose tissue and their abilities to differentiate into mature cells of various tissue lineages and secrete various growth cytokines. Development of tissue engineering techniques in combination with various carrier scaffolds and adipose stem cells offers great potential in overcoming the existing limitations constraining classical approaches used in plastic and reconstructive surgery. However, as most tissue engineering techniques are new and highly experimental, there are still many practical challenges that must be overcome before laboratory research can lead to large-scale clinical applications. Tissue engineering is currently a growing field of medical research; in this review, we will discuss the progress in research on biomaterials and scaffolds for tissue engineering applications using adipose stem cells.

Direct optical observations of vesicular self-assembly in large-scale polymeric structures during photocontrolled biphasic polymerization

2016 ◽  
Vol 7 (47) ◽  
pp. 7211-7215 ◽  
Author(s):  
Jan K. Szymański ◽  
Juan Pérez-Mercader
Keyword(s):  
Self Assembly ◽  
Large Scale ◽  
Dispersion Polymerization ◽  
Optical Observations ◽  
Controlled Polymerization ◽  
Self Assembled ◽  
Polymeric Structures

In this report, we employ a photo-controlled polymerization protocol featuring a fluorescent initiator to follow the evolution of the generated self-assembled microscopic structures in a phase-separating dispersion polymerization medium.

Engineering of biomimetic nanofibrous matrices for drug delivery and tissue engineering

2014 ◽  
Vol 2 (45) ◽  
pp. 7828-7848 ◽  
Author(s):  
Chuanglong He ◽  
Wei Nie ◽  
Wei Feng
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Phase Separation ◽  
Self Assembly ◽  
Engineering Applications

Biomimetic nanofibrous matrices were fabricated by electrospinning, phase separation and molecular self-assembly for drug delivery and tissue engineering applications.

Engineered tubular structures based on chitosan for tissue engineering applications

2017 ◽  
Vol 32 (7) ◽  
pp. 841-852 ◽  
Author(s):  
Joana M Silva ◽  
Luísa C Rodrigues ◽  
Simone S Silva ◽  
Rui L Reis ◽  
Ana Rita C Duarte
Keyword(s):  
Tissue Engineering ◽  
Tubular Structures ◽  
Engineering Applications

Supramolecular Polymers for Potential Biomedical Applications

2011 ◽  
Vol 410 ◽  
pp. 94-97 ◽  
Author(s):  
Jun Li
Keyword(s):  
Tissue Engineering ◽  
Block Copolymers ◽  
Gene Delivery ◽  
Self Assembly ◽  
Functional Materials ◽  
Supramolecular Structures ◽  
Potential Drug ◽  
Engineering Applications ◽  
Supramolecular Architectures ◽  
Gene Delivery Vectors

The phenomena of molecular self-assembly have inspired interesting development of novel functional materials. We have been focusing on developing novel polymers with the ability to self-assemble into novel supramolecular structures, which can function as biomaterials for potential drug/gene delivery and tissue engineering applications. The key components in our macromolecular self-assembling structures include the biodegradable and biocompatible microbial biopolyesters, poly (β-hydroxyalkanoates), and the macrocyclic polysaccharides, cyclodextrins. A series of novel block copolymers and interlocked supramolecular architectures were designed and synthesized. They were characterized in terms of their molecular and supramolecular structures, as well as their properties and functions as biomaterials for potential drug and gene delivery, and tissue engineering applications. Amphiphilic block copolymers of different chain architectures composed of poly [(R)-3-hydroxybutyrate] as hydrophobic segments, and poly (ethylene glycol), poly (propylene glycol), or poly (N-isopropylacrylamide) as hydrophilic segments were synthesized. They could self-assemble to form stable micelles, nanopatterning thin films, and thermo-sensitive hydrogels, which were demonstrated to be promising potential biomaterials for controlled and sustained delivery of drugs and tissue engineering scaffolding materials. The self-assembly of block copolymers with cyclodextrins resulted in supramolecular hydrogels and cationic supramolecules, which were used as injectable drug delivery systems, and novel polymeric gene delivery vectors.

scholarly journals Reconstruction of Vascular and Urologic Tubular Grafts by Tissue Engineering

Processes ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 513
Author(s):  
Christophe Caneparo ◽  
Stéphane Chabaud ◽  
Stéphane Bolduc
Keyword(s):  
Tissue Engineering ◽  
Health Status ◽  
20Th Century ◽  
Self Assembly ◽  
New Technology ◽  
Tubular Structures ◽  
Immune Rejection ◽  
Late 20Th Century ◽  
Initial Biopsy

Tissue engineering is one of the most promising scientific breakthroughs of the late 20th century. Its objective is to produce in vitro tissues or organs to repair and replace damaged ones using various techniques, biomaterials, and cells. Tissue engineering emerged to substitute the use of native autologous tissues, whose quantities are sometimes insufficient to correct the most severe pathologies. Indeed, the patient’s health status, regulations, or fibrotic scars at the site of the initial biopsy limit their availability, especially to treat recurrence. This new technology relies on the use of biomaterials to create scaffolds on which the patient’s cells can be seeded. This review focuses on the reconstruction, by tissue engineering, of two types of tissue with tubular structures: vascular and urological grafts. The emphasis is on self-assembly methods which allow the production of tissue/organ substitute without the use of exogenous material, with the patient’s cells producing their own scaffold. These continuously improved techniques, which allow rapid graft integration without immune rejection in the treatment of severely burned patients, give hope that similar results will be observed in the vascular and urological fields.

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