Direct access to stabilized CuI using cuttlebone as a natural-reducing support for efficient CuAAC click reactions in water

RSC Advances ◽  
2016 ◽  
Vol 6 (68) ◽  
pp. 63613-63623 ◽  
Author(s):  
Sara S. E. Ghodsinia ◽  
Batool Akhlaghinia ◽  
Roya Jahanshahi
Keyword(s):  
Heterogeneous Catalyst ◽  
Cycloaddition Reaction ◽  
Direct Access ◽  
Dipolar Cycloaddition ◽  
One Pot ◽  
Click Reactions ◽  
Highly Active ◽  
The One ◽  
Reaction In Water

Cuttlebone@CuCl2 as a highly active, versatile, and green heterogeneous catalyst was investigated for the efficient preparation of 1,4-disubstituted 1,2,3-triazoles through the one-pot Huisgen 1,3-dipolar cycloaddition reaction in water.

scholarly journals Highly Active and Reusable Cu/C Catalyst for Synthesis of 5-Substituted 1H-Tetrazoles Starting from Aromatic Aldehydes

2020 ◽  
Vol 67 (4) ◽  
pp. 1044-1052
Author(s):  
Reza Khalifeh ◽  
Najme Rastegar ◽  
Dariush Khalili
Keyword(s):  
Sodium Azide ◽  
Cycloaddition Reaction ◽  
Aromatic Aldehydes ◽  
Significant Loss ◽  
One Pot ◽  
Highly Active ◽  
Wide Range ◽  
Simple Filtration ◽  
The One ◽  
Tetrazole Derivatives

A new, efficient and convenient method for the synthesis of 5-substituted 1H-tetrazole derivatives with a wide range of substituents in good to excellent yields has been developed. The synthesis was performed by the one-pot three-component [3+2]cycloaddition reaction between aldehyde, hydroxylamine and sodium azide in the presence of Cu/C. The reaction probably proceeds by the in situ formation of nitriles followed by successive [3+2]cycloaddition with sodium azide. A variety of aldehydes were used to obtain the corresponding tetrazoles. The catalyst was recovered by simple filtration and reused at least five times without significant loss of catalytic activity. The use of this method offers additional advantages for the synthesis of 5-substituted 1H-tetrazole derivatives, including the easy availability of starting materials, mild conditions, experimental simplicity and good yields.

One-Pot Catalyst-Free Domino Condensation/Intramolecular 1,3-Dipolar Cycloaddition: Highly Stereoselective Access to Phosphadihydrocoumarin-Fused N,N-Bicyclic Pyrazolidin-3-ones

Synthesis ◽  
2017 ◽  
Vol 50 (01) ◽  
pp. 139-145 ◽  
Author(s):  
Mingshu Wu ◽  
Jie Jiang ◽  
Zhongxiang Zhu ◽  
Qinghe Wang ◽  
Dulin Kong
Keyword(s):  
Low Cost ◽  
Cycloaddition Reaction ◽  
Dipolar Cycloaddition ◽  
Nitrogen And Phosphorus ◽  
One Pot ◽  
Intramolecular Cycloaddition ◽  
Catalyst Free ◽  
Synthetic Strategy ◽  
The One ◽  
High Stereoselectivity

A concise, atom-economic, and highly regio/stereoselective synthetic strategy was developed for the construction of phosphorus- and nitrogen-fused polycyclic skeleton derivatives. The one-pot, two-step, catalyst-free domino condensation/intramolecular cycloaddition reaction of various substituted 2-(vinylphosphoryloxy)benzaldehydes with pyrazolidin-3-one took place at room temperature. Three new bonds (C–C, 2 × C–N) and two new nitrogen and phosphorus heterocycles were simultaneously constructed. The reaction is particularly attractive due to features such as low cost, mild conditions, atom economy, high stereoselectivity, and potential biological activity of the product.

1-(2′-Benzimidazolylmethyl)-pyridinium ylide in the one-pot synthesis of indolizine and benzimidazo[1,2-a]pyridine derivatives

2015 ◽  
Vol 70 (8) ◽  
pp. 555-561 ◽  
Author(s):  
Roumaissa Belguedj ◽  
Sofiane Bouacida ◽  
Hocine Merazig ◽  
Ali Belfaitah ◽  
Abdelmalek Bouraiou
Keyword(s):  
Nmr Spectroscopy ◽  
Cycloaddition Reaction ◽  
Dipolar Cycloaddition ◽  
Pyridine Derivatives ◽  
One Pot ◽  
X Ray ◽  
X Ray Crystallography ◽  
Dimethyl Maleate ◽  
The One ◽  
Pyridinium Ylide

AbstractFour indolizine derivatives were obtained via 1,3-dipolar cycloaddition reaction of 1-(2′-benzimidazolylmethyl)pyridinium ylide with various electron-deficient alkynes. The reaction of this pyridinium N-ylide with dimethyl maleate gave an unexpected methyl 1-oxo-benzimidazo[1,2-a]pyridine-3-carboxylate. The structures of all reported compounds have been examined by X-ray crystallography and NMR spectroscopy.

One-pot fructose conversion into 5-ethoxymethylfurfural using a highly active and stable heterogeneous catalyst of sulfonated hydrophobic mesoporous organic polymer

2021 ◽  
Author(s):  
Pandian Manjunathan ◽  
Pravin P Upare ◽  
Maeum Lee ◽  
Dongwon Hwang
Keyword(s):  
Heterogeneous Catalyst ◽  
Organic Polymer ◽  
One Pot ◽  
Highly Efficient ◽  
Highly Active ◽  
The One ◽  
Efficient Heterogeneous Catalyst

We report a sulfonated hydrophobic mesoporous organic polymer (MOP-SO3H) as a highly efficient heterogeneous catalyst for the one-pot 5-ethoxymethylfurfural (EMF) production from fructose in ethanol solvent. MOP-SO3H was fabricated by...

Copper-catalyzed Convenient Synthesis and SAR Studies of Substituted-1,2,3-triazole as Antimicrobial Agents

2018 ◽  
Vol 16 (1) ◽  
pp. 3-10
Author(s):  
Aniket P. Sarkate ◽  
Kshipra S. Karnik ◽  
Pravin S. Wakte ◽  
Ajinkya P. Sarkate ◽  
Ashwini V. Izankar ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antifungal Activity ◽  
Antimicrobial Agents ◽  
Cycloaddition Reaction ◽  
Dipolar Cycloaddition ◽  
One Pot ◽  
Triazole Derivatives ◽  
Sar Studies ◽  
Convenient Synthesis ◽  
Antibacterial And Antifungal

Background:A novel copper-catalyzed synthesis of substituted-1,2,3-triazole derivatives has been developed and performed by Huisgen 1,3-dipolar cycloaddition reaction of azides with alkynes. The reaction is one-pot multicomponent.Objective:We state the advancement and execution of a methodology allowing for the synthesis of some new substituted 1,2,3-triazole analogues with antimicrobial activity.Methods:A series of triazole derivatives was synthesized by Huisgen 1,3-dipolar cycloaddition reaction of azides with alkynes. The structures of the synthesized compounds were elucidated and confirmed by 1H NMR, IR, MS and elemental analysis. All the synthesized compounds were tested for their antimicrobial activity against a series of strains of Bacillus subtilis, Staphylococcus aureus and Escherichia coli for antibacterial activity and against the strains of Candida albicans, Aspergillus flavus and Aspergillus nigar for antifungal activity, respectively.Results and Conclusion:From the antimicrobial data, it was observed that all the newly synthesized compounds showed good to moderate level of antibacterial and antifungal activity.

Rapid Access to Novel 1,2,3-Triazolo-Heterocyclic Scaffolds via Tandem Knoevenagel Condensation/Azide–Alkyne 1,3-Dipolar Cycloaddition Reaction in One Pot

2014 ◽  
Vol 16 (9) ◽  
pp. 466-477 ◽  
Author(s):  
Ram Awatar Maurya ◽  
Praveen Reddy Adiyala ◽  
D. Chandrasekhar ◽  
Chada Narsimha Reddy ◽  
Jeevak Sopanrao Kapure ◽  
...  
Keyword(s):  
Knoevenagel Condensation ◽  
Cycloaddition Reaction ◽  
Dipolar Cycloaddition ◽  
One Pot ◽  
Rapid Access
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