The use of ionic liquid as a mobile phase modifier in analytical supercritical fluid chromatography for the separation of flavonoids

RSC Advances ◽  
2016 ◽  
Vol 6 (66) ◽  
pp. 61418-61422 ◽  
Author(s):  
Wen Gao ◽  
Xin Dong ◽  
Rui Wang ◽  
Xin-Guang Liu ◽  
Ping Li ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Supercritical Fluid ◽  
Supercritical Fluid Chromatography ◽  
Mobile Phase ◽  
Mobile Phase Modifier ◽  
Flavonoid Aglycone

This paper presents a method that the uses ionic liquids (ILs) as a mobile phase modifier in supercritical fluid chromatography (SFC) for flavonoid aglycone analysis, significantly improving the resolution and changing the selectivity.

Ionic Liquids as Novel Solvent Additives to Separate Peptides

2006 ◽  
Vol 61 (11-12) ◽  
pp. 827-832 ◽  
Author(s):  
Tomasz Bączek ◽  
Barbara Sparzak
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Thin Layer ◽  
Mobile Phase ◽  
Analytical Approach ◽  
Quantitative Structure ◽  
Methyl Sulfate ◽  
Liquid Content ◽  
Structure Retention ◽  
Layer Chromatography

Abstract A novel analytical approach involving the addition of an ionic liquid into the mobile phase of the thin-layer chromatography (TLC) system during the optimization of chromatographic separation of peptides was demonstrated. Different behavior of peptides in the TLC sytem was observed after the addition of 1,3-dimethylimidazolium methyl sulfate to the eluent in comparison to the system without the ionic liquid. The objective of the work was to study the effect of the addition of different contents of ionic liquid to the mobile phase comprising mostly water and to observe the behavior of peptides’ retention. The potential usefulness of environmentally friendly ionic liquids for the optimization of separation of peptides was demonstrated. An increase of Rf values was observed with increasing the ionic liquid content in the mobile phase. The benefits of the used approach were related to the separation achieved. Finally, quantitative structure-retention relationships (QSRR) were used for the studies on the predictions of peptides’ retention in the TLC systems with the addition of ionic liquid in terms of the predictions performed recently in HPLC systems.

Supercritical fluid chromatography and microbore liquid chromatography for drug analysis.

1989 ◽  
Vol 35 (7) ◽  
pp. 1293-1298 ◽  
Author(s):  
S H Wong
Keyword(s):  
Liquid Chromatography ◽  
Supercritical Fluid ◽  
Supercritical Fluid Chromatography ◽  
Mobile Phase ◽  
Applied Pressure ◽  
Forensic Toxicology ◽  
Drug Analysis ◽  
Low Viscosity ◽  
Potential Applications ◽  
Microbore Liquid Chromatography

Abstract Supercritical fluid and microbore liquid chromatography offer potential applications for drug analysis. In supercritical fluid chromatography (SFC), the mobile phase is a gas (e.g., carbon dioxide) maintained at its supercritical state--that is, above its critical temperature and pressure, above which it cannot be liquefied even with further increases in applied pressure. The SFC mobile phase has low viscosity, approximating that of a gas, and high diffusivity, between those of a gas and a liquid. These properties yield favorable column efficiency, between that of capillary gas chromatography (GC) and liquid chromatography (LC). SFC analysis may be performed by either packed or open tubular capillary columns and with GC and LC detectors. SFC, interfaced with mass spectrometry, may become a viable alternative to GC/MS for drug identification in clinical and forensic toxicology. Advantages of microbore liquid chromatography include enhanced mass sensitivity, reduced solvent consumption, and others. Microbore columns (internal diameters 1 to 2 mm) may be packed with 3-, 5-, or 10-micron particles. Potential applications include micro-sample analysis (5-200 microL) for neonatal and pediatric drug monitoring, and drug confirmation analysis for toxicology.

Chlorodifluoromethane as the mobile phase in supercritical fluid chromatography of selected phenols

1990 ◽  
Vol 62 (14) ◽  
pp. 1389-1391 ◽  
Author(s):  
Chye Peng. Ong ◽  
Hian Kee. Lee ◽  
Sam Fong Yau. Li
Keyword(s):  
Supercritical Fluid ◽  
Supercritical Fluid Chromatography ◽  
Mobile Phase

New system for delivery of the mobile phase in supercritical fluid chromatography

1984 ◽  
Vol 56 (14) ◽  
pp. 2681-2684 ◽  
Author(s):  
Tyge. Greibrokk ◽  
Ann Lisbeth. Blilie ◽  
Einar J. Johansen ◽  
Elsa. Lundanes
Keyword(s):  
Supercritical Fluid ◽  
Supercritical Fluid Chromatography ◽  
Mobile Phase ◽  
New System

Stationary- and Mobile-Phase Interactions in Supercritical Fluid Chromatography

1999 ◽  
pp. 96-118 ◽  
Author(s):  
Sihua Xu ◽  
Phillip S. Wells ◽  
Yingmei Tao ◽  
Kwang S. Yun ◽  
J. F. Parcher
Keyword(s):  
Supercritical Fluid ◽  
Supercritical Fluid Chromatography ◽  
Mobile Phase
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