scholarly journals Electrostatic self-assembled graphene oxide-collagen scaffolds towards a three-dimensional microenvironment for biomimetic applications

RSC Advances ◽  
2016 ◽  
Vol 6 (54) ◽  
pp. 49039-49051 ◽  
Author(s):  
André F. Girão ◽  
Gil Gonçalves ◽  
Kulraj S. Bhangra ◽  
James B. Phillips ◽  
Jonathan Knowles ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Three Dimensional ◽  
Collagen Scaffolds ◽  
Carboxylic Groups ◽  
Amine Groups ◽  
Self Assembled ◽  
Cellular Microenvironments

The manipulation of the interactions between the cationic amine groups from collagen and the anionic carboxylic groups from graphene oxide mediate the synthesis of a self-assembled hydrogel capable of generate suitable 3D cellular microenvironments.

Three-Dimensional Hierarchical Frameworks Based on MoS2 Nanosheets Self-Assembled on Graphene Oxide for Efficient Electrocatalytic Hydrogen Evolution

2014 ◽  
Vol 6 (23) ◽  
pp. 21534-21540 ◽  
Author(s):  
Weijia Zhou ◽  
Kai Zhou ◽  
Dongman Hou ◽  
Xiaojun Liu ◽  
Guoqiang Li ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Hydrogen Evolution ◽  
Three Dimensional ◽  
Mos2 Nanosheets ◽  
Self Assembled

scholarly journals Ultrasensitive bioassaying of HER-2 protein for diagnosis of breast cancer using reduced graphene oxide/chitosan as nanobiocompatible platform

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Hassan Nasrollahpour ◽  
Ibrahim Isildak ◽  
Mohammad-Reza Rashidi ◽  
Esmat Alsadat Hashemi ◽  
Abdolhosein Naseri ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Limit Of Detection ◽  
Test Method ◽  
Reduced Graphene ◽  
Relative Standard ◽  
Carboxylic Groups ◽  
Her 2 ◽  
Amine Groups

Abstract Background In this label-free bioassay, an electrochemiluminescence (ECL) immunosensor was developed for the quantification of breast cancer using HER-2 protein as a metastatic biomarker. Method For this purpose, the ECL emitter, [Ru(bpy)3]2+, was embedded into biocompatible chitosan (CS) polymer. The prepared bio-composite offered high ECL reading due to the depletion of human epidermal growth factor receptor 2 (HER-2) protein. Reduced graphene oxide (rGO) was used as substrate to increase signal stability and achieve greater sensitivity. For this, rGO was initially placed electrochemically on the glassy carbon electrode (GCE) surface by cyclic voltammetry (CV) technique. Next, the prepared CS/[Ru(bpy)3]2+ biopolymer solution was coated on a drop of the modified electrode such that the amine groups of CS and the carboxylic groups of rGO could covalently interact. Using EDC/NHS chemistry, monoclonal antibodies (Abs) of HER-2 were linked to CS/[Ru(bpy)3]2+/rGO/GCE via amide bonds between the carboxylic groups of Ab molecules and amine groups of CS. The electrochemical behavior of the electrode was studied using different electrochemical techniques such as electrochemical impedance spectroscopy (EIS), differential pulse voltammetry (DPV) and square wave voltammetry (SWV) and also ECL tests. Results After passing all optimization steps, the lower limit of detection (LLOQ) and linear dynamic range (LDR) of HER-2 protein were practically obtained as 1 fM and 1 fM to 1 nM, individually. Importantly, the within and between laboratory precisions were performed and the suitable relative standard deviations (RSDs) were recorded as 3.1 and 3.5%, respectively. Conclusions As a proof of concept, the designed immunosensor was desirably applied for the quantification of HER-2 protein in breast cancer suffering patients. As a result, the designed ECL-based immunosensor has the capability of being used as a conventional test method in biomedical laboratories for early detection of HER-2 protein in biological fluids. Graphic Abstract

In Situ Synthesis of Three-Dimensional Self-Assembled Metal Oxide–Reduced Graphene Oxide Architecture

2014 ◽  
Vol 26 (16) ◽  
pp. 4838-4843 ◽  
Author(s):  
Hyun-Kyung Kim ◽  
Sang-Hoon Park ◽  
Seung-Beom Yoon ◽  
Chang-Wook Lee ◽  
Jun Hui Jeong ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Metal Oxide ◽  
Reduced Graphene Oxide ◽  
Three Dimensional ◽  
In Situ Synthesis ◽  
Reduced Graphene ◽  
Self Assembled

Three-dimensional self-assembled graphene oxide/enzyme in the presence of copper phosphate

2015 ◽  
Vol 1 (4) ◽  
pp. 045101 ◽  
Author(s):  
Linlin Duan ◽  
Huixian Wang ◽  
Jindun Liu ◽  
Yatao Zhang
Keyword(s):  
Graphene Oxide ◽  
Three Dimensional ◽  
Copper Phosphate ◽  
Self Assembled

Self-assembled reduced graphene hydrogels by facile chemical reduction using acetaldehyde oxime for electrode materials in supercapacitors

RSC Advances ◽  
2016 ◽  
Vol 6 (54) ◽  
pp. 48276-48282 ◽  
Author(s):  
Man Jiang ◽  
Jing-Li Zhang ◽  
Fei Qiao ◽  
Rui-Ying Zhang ◽  
Ling-Bao Xing ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Electrode Materials ◽  
Chemical Reduction ◽  
Three Dimensional ◽  
Doping Agent ◽  
Reduced Graphene ◽  
Self Assembled

Self-assembled three-dimensional (3D) reduced graphene hydrogels (RGHs) were fabricated by the facile chemical reduction of a graphene oxide (GO) dispersion with ammonia using acetaldehyde oxime as reducing and doping agent.

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