Synthesis, structure, electrochemical, DNA interaction and antimicrobial studies of fluorinated trans-dicationic pyridinium porphyrins

RSC Advances ◽  
2016 ◽  
Vol 6 (68) ◽  
pp. 63271-63285 ◽  
Author(s):  
Jagadeesan Ramesh ◽  
Subramaniam Sujatha ◽  
Chellaiah Arunkumar
Keyword(s):  
Dna Interaction ◽  
Antimicrobial Activities ◽  
Calf Thymus Dna ◽  
Groove Binding ◽  
Antimicrobial Studies ◽  
Calf Thymus ◽  
Artificial Nucleases

trans-Dicationic pyridinium porphyrins are superior artificial nucleases compared to their non-fluorinated analogues and bind with calf thymus DNA by outside groove binding with or without self-stacking, also show significant antimicrobial activities.

Surfactant Complex Binding to DNA Interaction Study: Controlling Hydrophobicity in β-Cyclodextrin–DNA Binding Reactions

2020 ◽  
pp. 318-332
Author(s):  
Nagaraj Karuppiah ◽  
◽  
Muthukumaran Pakkirisamy ◽  
Gunasekaran Gladwin ◽  
Keyword(s):  
Dna Interaction ◽  
Spectroscopic Studies ◽  
Calf Thymus Dna ◽  
Aliphatic Chain ◽  
Groove Binding ◽  
Base Pairs ◽  
Surfactant Complex ◽  
Calf Thymus ◽  
Frame Work ◽  
Ct Dna

The interaction of cis-[Co(phen)2(TA)2](ClO4)3, a cationic surfactant complex (phen = 1-10 phenanthroline, TA= Tetradecylamine), with calf thymus DNA has been studied by physici-chemical techniques. The spectroscopic studies together with cyclic voltammetry and viscosity experiments support that the surfactant-cobalt(III) complex binds to calf thymus DNA (CT DNA) by intercalation through the aliphatic chain present in the complex into the base pairs of DNA. The presence of phenanthroline ligand with larger -frame work may also enhance intercalation. Besides the effect of binding of surfactant cobalt(III) complex to DNA in presence of -cyclodextrin has also studied. In presence of -cyclodextrin the binding occur through surface and (or) groove binding. The complex was investigated as one of the potential

Studies on free radical scavenging, cancer cell antiproliferation, and calf thymus DNA interaction of Schiff bases

2017 ◽  
Vol 172 ◽  
pp. 129-138 ◽  
Author(s):  
Cleiton M. da Silva ◽  
Marina M. Silva ◽  
Fabiano S. Reis ◽  
Ana Lúcia T.G. Ruiz ◽  
João E. de Carvalho ◽  
...  
Keyword(s):  
Free Radical ◽  
Schiff Bases ◽  
Cancer Cell ◽  
Radical Scavenging ◽  
Dna Interaction ◽  
Free Radical Scavenging ◽  
Calf Thymus Dna ◽  
Calf Thymus

Insights into the mechanism of groove binding between 4–octylphenol and calf thymus DNA

2020 ◽  
Vol 238 ◽  
pp. 118454 ◽  
Author(s):  
Na Li ◽  
Xing Hu ◽  
Junhui Pan ◽  
Ying Zhang ◽  
Deming Gong ◽  
...  
Keyword(s):  
Calf Thymus Dna ◽  
Groove Binding ◽  
Calf Thymus

scholarly journals Interaction of Calf Thymus DNA with the Ni(II) Complex of Sodium 1,4-Dihydroxy-9,10-Anthraquinone-2-Sulphonate: A Novel Method of Analysis Using Cyclic Voltammetry

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Partha Sarathi Guin ◽  
Piyal Das ◽  
Saurabh Das ◽  
Parikshit Chandra Mandal
Keyword(s):  
Cyclic Voltammetry ◽  
Metal Ion ◽  
Dna Interaction ◽  
Calf Thymus Dna ◽  
Reduction Peak ◽  
Curve Fit ◽  
Diffusion Controlled ◽  
Binding Data ◽  
Calf Thymus ◽  
Electron Reduction

Hydroxy-9,10-anthraquinones are cheaper alternatives to anthracycline drugs. They closely resemble anthracycline drugs both from a structural and functional viewpoint. Electrochemical behavior of the Ni(II) complex (Na2[Ni(NaLH)2Cl2]⋅2H2O) of sodium 1,4-dihydroxy-9,10-anthraquinone-2-sulphonate (NaLH2), analogue of the core unit of anthracycline anticancer drugs, was studied at physiological pH using cyclic voltammetry. The Ni(II) complex of sodium 1,4-dihydroxy-9,10-anthraquinone-2-sulphonate undergoes diffusion-controlled one-electron reduction that enables performing an electrochemical study on the interaction of the complex with calf thymus DNA. The complex was titrated with increasing concentrations of DNA, and the reduction peak for the unbound complex helped in evaluating binding parameters. Analysis of binding data using nonlinear curve fit in a cyclic voltammetry experiment is the first such attempt. The paper evaluates site size of interaction that also serves as a means to determine stoichiometry of complex formation, between a metal ion and ligand from a DNA interaction study, probably a first of its kind.

Characterization of the groove binding between di-(2-ethylhexyl) phthalate and calf thymus DNA

2017 ◽  
Vol 101 ◽  
pp. 736-746 ◽  
Author(s):  
Song Li ◽  
Junhui Pan ◽  
Guowen Zhang ◽  
Jianjian Xu ◽  
Deming Gong
Keyword(s):  
Calf Thymus Dna ◽  
Groove Binding ◽  
Calf Thymus ◽  
Ethylhexyl Phthalate

scholarly journals Exploration of Electrochemical Intermediates of the Anticancer Drug Doxorubicin Hydrochloride Using Cyclic Voltammetry and Simulation Studies with an Evaluation for Its Interaction with DNA

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Partha Sarathi Guin ◽  
Saurabh Das
Keyword(s):  
Cyclic Voltammetry ◽  
Anticancer Drug ◽  
Dna Interaction ◽  
Calf Thymus Dna ◽  
Potential Range ◽  
Spectroscopic Techniques ◽  
Doxorubicin Hydrochloride ◽  
Cathodic Peak ◽  
Peak Current ◽  
Calf Thymus

Electrochemical behavior of the anticancer drug doxorubicin hydrochloride was studied using cyclic voltammetry in aqueous medium using Hepes buffer (pH~7.4). At this pH, doxorubicin hydrochloride undergoes a reversible two-electron reduction withE1/2value −665±5 mV (versus Ag/AgCl, saturated KCl). Depending on scan rates, processes were either quasireversible (at low scan rates) or near perfect reversible (at high scan rates). This difference in behavior of doxorubicin hydrochloride with scan rate studied over the same potential range speaks of differences in electron transfer processes in doxorubicin hydrochloride. Attempt was made to identify and understand the species involved using simulation. The information obtained was used to study the interaction of doxorubicin hydrochloride with calf thymus DNA. Cathodic peak current gradually decreased as more calf thymus DNA was added. The decrease in cathodic peak current was used to estimate the interaction of the drug with calf thymus DNA. Nonlinear curve fit analysis was applied to evaluate the intrinsic binding constant and site size of interaction that was compared with previous results on doxorubicin hydrochloride-DNA interaction monitored by cyclic voltammetry or spectroscopic techniques.

Thermodynamic Study of Rhodamine 123-Calf Thymus DNA Interaction: Determination of Calorimetric Enthalpy by Optical Melting Study

2014 ◽  
Vol 118 (46) ◽  
pp. 13151-13161 ◽  
Author(s):  
Abdulla Al Masum ◽  
Maharudra Chakraborty ◽  
Prateek Pandya ◽  
Umesh Chandra Halder ◽  
Md. Maidul Islam ◽  
...  
Keyword(s):  
Dna Interaction ◽  
Thermodynamic Study ◽  
Calf Thymus Dna ◽  
Rhodamine 123 ◽  
Calf Thymus
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