Osteochondral scaffold combined with aligned nanofibrous scaffolds for cartilage regeneration

RSC Advances ◽  
2016 ◽  
Vol 6 (76) ◽  
pp. 72246-72255 ◽  
Author(s):  
Paul Lee ◽  
Ohan S. Manoukian ◽  
Gan Zhou ◽  
Yuhao Wang ◽  
Wei Chang ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Cartilage Repair ◽  
Subchondral Bone ◽  
Osteochondral Defect ◽  
Cartilage Regeneration ◽  
Articular Cartilage Repair ◽  
Significant Challenge ◽  
Osteochondral Scaffold ◽  
Nanofibrous Scaffolds ◽  
Defect Repair

Osteochondral defect repair poses a significant challenge in its reconstruction as the damage is presented in both articular cartilage and the underlying subchondral bone. Thus we present a osteochondral scaffold for articular cartilage repair.

scholarly journals In Situ Crosslinking Elastin-Like Polypeptide Gels for Application to Articular Cartilage Repair in a Goat Osteochondral Defect Model

2008 ◽  
Vol 14 (7) ◽  
pp. 1133-1140 ◽  
Author(s):  
Dana L. Nettles ◽  
Kenichi Kitaoka ◽  
Neil A. Hanson ◽  
Charlene M. Flahiff ◽  
Brian A. Mata ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Cartilage Repair ◽  
Osteochondral Defect ◽  
Defect Model ◽  
Articular Cartilage Repair ◽  
In Situ Crosslinking

scholarly journals Evaluation of articular cartilage repair using biodegradable nanofibrous scaffolds in a swine model: a pilot study

2009 ◽  
Vol 3 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Wan-Ju Li ◽  
Hongsen Chiang ◽  
Tzong-Fu Kuo ◽  
Hsuan-Shu Lee ◽  
Ching-Chuan Jiang ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Pilot Study ◽  
Cartilage Repair ◽  
Swine Model ◽  
Articular Cartilage Repair ◽  
Nanofibrous Scaffolds

Epidemiology and imaging of the subchondral bone in articular cartilage repair

2010 ◽  
Vol 18 (4) ◽  
pp. 463-471 ◽  
Author(s):  
Jacques Menetrey ◽  
Florence Unno-Veith ◽  
Henning Madry ◽  
Iwan Van Breuseghem
Keyword(s):  
Articular Cartilage ◽  
Cartilage Repair ◽  
Subchondral Bone ◽  
Articular Cartilage Repair

scholarly journals The subchondral bone in articular cartilage repair: current problems in the surgical management

2010 ◽  
Vol 18 (4) ◽  
pp. 434-447 ◽  
Author(s):  
Andreas H. Gomoll ◽  
Henning Madry ◽  
Gunnar Knutsen ◽  
Niek van Dijk ◽  
Romain Seil ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Surgical Management ◽  
Cartilage Repair ◽  
Subchondral Bone ◽  
Articular Cartilage Repair

CRITICAL-SIZED OSTEOCHONDRAL DEFECTS OF YOUNG MINIATURE PIGS AS A PRECLINICAL MODEL FOR ARTICULAR CARTILAGE REPAIR

2014 ◽  
Vol 26 (01) ◽  
pp. 1450003
Author(s):  
Chih-Hung Chang ◽  
Yuan-Ming Hsu ◽  
Chun-Ni Hsiao ◽  
Tzong-Fu Kuo ◽  
Ming-Huang Chang
Keyword(s):  
Articular Cartilage ◽  
Cartilage Repair ◽  
Osteochondral Defect ◽  
Blue Staining ◽  
Osteochondral Defects ◽  
Miniature Pig ◽  
Full Thickness ◽  
Articular Cartilage Repair ◽  
Miniature Pigs ◽  
Spontaneous Repair

Purpose: Evaluation by animal models is essential for tissue engineering-based articular cartilage repair techniques. Larger animals are considered to more closely approximate the clinical situations in translational medicine. Therefore, we used miniature pigs and induced full-thickness and osteochondral defects in them. We also studied if there were instances of spontaneous repair for providing baseline data for further cartilage regeneration study. Methods: A total of 12 miniature pigs with average age of 7.4 months were used in this study. Full-thickness and osteochondral defects with 2.7, 4.5 or 8.0 mm diameter were created at medial femoral condyles in the same pig, respectively. The pigs were sacrificed at 8, 16, 24 and 48 weeks. Gross appearances of defects were observed at aforementioned time points, and the histological analyses, including H&E and alcian blue staining, were performed for consequent evaluation as well. Results: The results showed that defects created in the center of the femoral condoyle migrated to periphery, and it implied that the pigs were still growing after 7–8 months of age. However, spontaneous repair was observed in 2.7 mm diameter defects but rarely seen in 4.5 and 8 mm diameter osteochondral defects. On the other hand, osteochondral defects repaired better than defects of full-thickness in the same 2.7 mm diameter. Conclusions: In order to prevent spontaneous repair of osteochondral defect in a young miniature pig animal model, a critical-sized osteochondral defect larger than 40% width of femoral medial condyle (4.5 mm in miniature pig) and observation period for more than 48 weeks are suggested by this study.

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