Construction and drug delivery of a fluorescent TPE-bridged cyclodextrin/hyaluronic acid supramolecular assembly

RSC Advances ◽  
2016 ◽  
Vol 6 (56) ◽  
pp. 50673-50679 ◽  
Author(s):  
Qian Zhao ◽  
Yong Chen ◽  
Mo Sun ◽  
Xian-Jing Wu ◽  
Yu Liu
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Supramolecular Assembly

A luminescent supramolecular assembly was constructed for drug delivery.

scholarly journals Strategies for Hyaluronic Acid-Based Hydrogel Design in Drug Delivery

Pharmaceutics ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 407 ◽  
Author(s):  
Sonia Trombino ◽  
Camilla Servidio ◽  
Federica Curcio ◽  
Roberta Cassano
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Drug Delivery Systems ◽  
Inclusion Complexation ◽  
Supramolecular Assembly ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Disulfide Crosslinking ◽  
Covalent Crosslinking ◽  
Physical And Chemical

Hyaluronic acid (HA) is a natural, linear, endogenous polysaccharide that plays important physiological and biological roles in the human body. Nowadays, among biopolymers, HA is emerging as an appealing starting material for hydrogels design due to its biocompatibility, native biofunctionality, biodegradability, non-immunogenicity, and versatility. Since HA is not able to form gels alone, chemical modifications, covalent crosslinking, and gelling agents are always needed in order to obtain HA-based hydrogels. Therefore, in the last decade, different strategies for the design of physical and chemical HA hydrogels have been developed, such as click chemistry reactions, enzymatic and disulfide crosslinking, supramolecular assembly via inclusion complexation, and so on. HA-based hydrogels turn out to be versatile platforms, ranging from static to smart and stimuli-responsive systems, and for these reasons, they are widely investigated for biomedical applications like drug delivery, tissue engineering, regenerative medicine, cell therapy, and diagnostics. Furthermore, the overexpression of HA receptors on various tumor cells makes these platforms promising drug delivery systems for targeted cancer therapy. The aim of the present review is to highlight and discuss recent advances made in the last years on the design of chemical and physical HA-based hydrogels and their application for biomedical purposes, in particular, drug delivery. Notable attention is given to HA hydrogel-based drug delivery systems for targeted therapy of cancer and osteoarthritis.

Recent Advances in the Development of Polymeric Nanocarrier Formulations for the Treatment of Colon Cancer

2019 ◽  
Vol 9 (1) ◽  
pp. 2-14
Author(s):  
Sahil Kumar ◽  
Bandna Sharma ◽  
Kiran Thakur ◽  
Tilak R. Bhardwaj ◽  
Deo N. Prasad ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Colon Cancer ◽  
Hyaluronic Acid ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Near Ir ◽  
Targeted Drug ◽  
Poly Ethylene ◽  
Novel Drug

Background: Many efforts have been explored in the last decade to treat colon cancer but nanoparticulate drug delivery systems are making a vital contribution in the improvement of drug delivery to colon cancer cells. Objective: In this review, we attempt to highlight recent advancements in the development of novel drug delivery systems of nanoparticles for the targeted drug delivery to colon. Polymers like Epithelial Cell Adhesion Molecule (EpCAM) aptamer chitosan, Hyaluronic Acid (HA), Chitosan (CS)– Carboxymethyl Starch (CMS), silsesquioxane capped mesoporous silica, Near IR (NIR) fluorescent Human Serum Albumin (HAS), poly(ethylene glycol)-conjugated hyaluronic acid etc. have been discussed by employing various anticancer drugs like doxorubicin, oxaliplatin, paclitaxel, 5-fluorouracil etc. Conclusion: These novel drug delivery systems have been determined to be more efficacious in terms of stability, sustained and targeted drug delivery, therapeutic efficacy, improved bioavailability and enhanced anticancer activity.

Pulmonary drug delivery with aerogels: engineering of alginate and alginate–hyaluronic acid microspheres

2021 ◽  
Vol 26 (5) ◽  
pp. 509-521
Author(s):  
Tamara Athamneh ◽  
Adil Amin ◽  
Edit Benke ◽  
Rita Ambrus ◽  
Pavel Gurikov ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Pulmonary Drug Delivery

Alginate and hybrid alginate-hyaluronic acid aerogel microspheres as potential carrier for pulmonary drug delivery

2019 ◽  
Vol 150 ◽  
pp. 49-55 ◽  
Author(s):  
Tamara Athamneh ◽  
Adil Amin ◽  
Edit Benke ◽  
Rita Ambrus ◽  
Claudia S. Leopold ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Pulmonary Drug Delivery

scholarly journals A Novel Crosslinked Hyaluronic Acid Nanogel for Drug Delivery

2014 ◽  
Vol 14 (11) ◽  
pp. 1556-1568 ◽  
Author(s):  
Sílvia Santos Pedrosa ◽  
Catarina Gonçalves ◽  
Laurent David ◽  
Miguel Gama
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid
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