Combined and individual doxorubicin/vancomycin drug loading, release kinetics and apatite formation for the CaO–CuO–P2O5–SiO2–B2O3 mesoporous glasses

RSC Advances ◽  
2016 ◽  
Vol 6 (56) ◽  
pp. 51046-51056 ◽  
Author(s):  
Gurbinder Kaur ◽  
O. P. Pandey ◽  
K. Singh ◽  
Bhupendra Chudasama ◽  
V. Kumar
Keyword(s):  
Release Kinetics ◽  
Drug Loading ◽  
Sol Gel ◽  
Apatite Formation ◽  
The Novel ◽  
Gel Technique ◽  
Glass Series

The novel mesoporous glass series based on (25 − x)CaO–xCuO–10P2O5–5B2O3–60SiO2 (x = 2.5, 5, 7.5, 10) has been prepared using the sol–gel technique.

scholarly journals Mesoporous Silica MCM-41 as a Carriers Material for Nystatine Drug in Delivery System

2019 ◽  
Vol 15 (2) ◽  
pp. 34-43 ◽  
Author(s):  
Talib M. Albayati ◽  
Ali M. AlKafajy
Keyword(s):  
Historical Data ◽  
Drug Loading ◽  
Sol Gel ◽  
Weibull Model ◽  
Gravimetric Analysis ◽  
X Ray Diffraction ◽  
Combine Process ◽  
X Ray ◽  
Gel Technique ◽  
Mcm 41

In the present study, MCM-41 was synthesis as a carrier for poorly drugs soluble in water, by the sol-gel technique. Textural and chemical characterizations of MCM-41 were carried out by X-ray diffraction (XRD), Fourier transform infrared (FTIR), scanning electron microscope (SEM), and thermal gravimetric analysis (TGA). The experimental results were analyzed mesoporous carriers MCM-41. With maximum drug loading efficiency in MCM-41 determined to be 90.74%. The NYS released was prudently studied in simulated body fluid (SBF) pH 7.4 and the results proved that the release of NYS from MCM-41 was (87.79%) after 18 hr. The data of NYS released was found to be submitted a Weibull model with a correlation coefficient of (0.995). The Historical data experimental design facilitated the formulation and optimization of sustained discover the optimal formulation to loading drug, combine process variables, mixture components and categorical factors in one design.

scholarly journals Drug Release of Hybrid Materials Containing Fe(II)Citrate Synthesized by Sol-Gel Technique

Materials ◽  
2018 ◽  
Vol 11 (11) ◽  
pp. 2270 ◽  
Author(s):  
Michelina Catauro ◽  
Elisabetta Tranquillo ◽  
Federico Barrino ◽  
Ignazio Blanco ◽  
Francesco Dal Poggetto ◽  
...  
Keyword(s):  
Ftir Spectroscopy ◽  
Hybrid Materials ◽  
Release Kinetics ◽  
Sol Gel ◽  
Antibacterial Properties ◽  
Biological Characterization ◽  
Sio2 Matrix ◽  
E Coli ◽  
Ferrous Citrate ◽  
Gel Technique

The use of oral iron integration is commonly recommended for the treatment of iron deficiency, nevertheless the diagnosis and treatment of this disease could clearly be improved. The aim of this work was the synthesis of therapeutic systems, iron (II) based, by sol-gel method. In an SiO2 matrix, we embedded different weight percentages of polyethylene glycol (PEG6, 12, 24 wt%) and ferrous citrate (Fe(II)C5, 10, 15 wt%) for drug delivery applications. Fourier Transform Infrared (FTIR) spectroscopy was used to study the interactions among different components in the hybrid materials. Release kinetics in a simulated body fluid (SBF) were investigated and the amount of Fe2+ released was detected by Ultraviolet–Visible spectroscopy (UV-VIS) after reaction with ortho-phenantroline. Furthermore, the biological characterization was carried out. The bioactivity of the synthesized hybrid materials was evaluated by the formation of a layer of hydroxyapatite on the surface of samples soaked in SBF using FTIR spectroscopy. Finally, also, the potential antibacterial properties of the different materials against two different bacteria, E. coli and P. aeruginosa, were investigated.

scholarly journals A Comparative Study on the Properties of Potentially Bioactive Glasses Obtained by Sol-Gel Technique and by Melting Mixtures of Oxides

2017 ◽  
Vol 15 (13) ◽  
pp. 18-24
Author(s):  
Daniela Avram ◽  
Dan Ungureanu ◽  
Nicolae Angelescu ◽  
José Barroso de Aguiar
Keyword(s):  
Mechanical Energy ◽  
Sol Gel ◽  
Diffraction Method ◽  
Sem Analysis ◽  
Thin Layers ◽  
Apatite Formation ◽  
Before And After ◽  
Gel Technique ◽  
The Fourier Transform

AbstractPhosphocalcic glasses, based on ternary system SiO2 - CaO- P2O5 and those doped with copper (SiO2 – CaO - P2O5 - Cu2O) can be obtained by the traditional method of sub-cooling melts or modern methods such as process that uses mechanical energy, neutrons action, deposition in thin layers or by sol-gel technique. This paper shows the experimental results of three compositional phosphocalcic glasses: 50% SiO2 - 43% CaO - 7% P2O5, 50% SiO2 - 38% CaO - 7% P2O5 - 5% Cu2O obtained through sol-gel method and 45% SiO2 - 22.5% CaO - 22.5 Na2O - 5% P2O5 - 5% Cu2O obtained by melting. In order to study their bioactivity, the three compositions were structural analyzed by X-ray diffraction method. In this case the apatite formation was highlighted after soaked in simulated body fluid, but also other compounds (CaCO3 and CuO) resulting from the same process were observed. In case of the melting glass apatite formation has not been highlighted. The functional groups present in the structure of glasses before and after soaking (PO43−, CO32− and HO−) were highlighted by the Fourier Transform Infrared Spectroscopy (FTIR). The elemental chemical composition was confirmed by elemental analysis WD-XRF. The morphology of sol-gel glass powders was revealed by SEM analysis. All glass compositions were tested in terms of antibacterial activity in vitro.

Preparation and Deposition of Hydroxyapatite on Biomaterials by Sol-Gel Technique-A Review

2013 ◽  
Vol 1 (2) ◽  
pp. 59-69 ◽  
Author(s):  
Sarbjit Kaur ◽  
Niraj Bala ◽  
Charu Khosla
Keyword(s):  
Sol Gel ◽  
Gel Technique

Mesoporous Silica Molecular Sieve based Nanocarriers: Transpiring Drug Dissolution Research

2017 ◽  
Vol 23 (3) ◽  
pp. 467-480 ◽  
Author(s):  
Satyanarayan Pattnaik ◽  
Kamla Pathak
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Molecular Sieves ◽  
Release Kinetics ◽  
Drug Loading ◽  
Scale Up ◽  
Water Soluble ◽  
Drug Dissolution ◽  
Water Soluble Drugs ◽  
Loading Methods

Background: Improvement of oral bioavailability through enhancement of dissolution for poorly soluble drugs has been a very promising approach. Recently, mesoporous silica based molecular sieves have demonstrated excellent properties to enhance the dissolution velocity of poorly water-soluble drugs. Description: Current research in this area is focused on investigating the factors influencing the drug release from these carriers, the kinetics of drug release and manufacturing approaches to scale-up production for commercial manufacture. Conclusion: This comprehensive review provides an overview of different methods adopted for synthesis of mesoporous materials, influence of processing factors on properties of these materials and drug loading methods. The drug release kinetics from mesoporous silica systems, the manufacturability and stability of these formulations are reviewed. Finally, the safety and biocompatibility issues related to these silica based materials are discussed.

Sol - Gel Technique Applied for Biomaterials Achievement

2011 ◽  
Vol 4 (3) ◽  
pp. 224-237 ◽  
Author(s):  
Aurica P. Chiriac ◽  
Loredana E. Nita ◽  
Iordana Neamtu ◽  
Manuela T. Nistor
Keyword(s):  
Sol Gel ◽  
Gel Technique

scholarly journals Tailoring Mesoporous Titania Features by Ultrasound-Assisted Sol-Gel Technique: Effect of Surfactant/Titania Precursor Weight Ratio

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1263
Author(s):  
Elvira Mahu ◽  
Cristina Giorgiana Coromelci ◽  
Doina Lutic ◽  
Iuliean Vasile Asaftei ◽  
Liviu Sacarescu ◽  
...  
Keyword(s):  
Photocatalytic Activity ◽  
Sol Gel ◽  
Weight Ratio ◽  
Soft Template ◽  
Synthesis Process ◽  
Mesoporous Titania ◽  
Cavitation Effect ◽  
Titania Precursor ◽  
Gel Technique ◽  
Ultrasound Assisted

A mesoporous titania structure has been prepared using the ultrasound-assisted sol-gel technique in order to find out a way to tailor its structure. The TiO2 obtained was compared to the same version of titania but synthesized by a conventional sol-gel method with the objective of understanding the effect of ultrasound in the synthesis process. All synthesis experiments were focused on the preparation of a titania photocatalyst. Thus, the anatase photocatalytic active phase of titania was proven by X-ray diffraction. Additionally, the ultrasonation treatment proved to increase the crystallinity of titania samples, being one of the requirements to having good photocatalytic activity for titania. The influence of surfactant/titania precursor weight ratio on the structural (XRD), textural (N2-sorption measurements), morphological (TEM), surface chemistry (FTIR) and optical properties (UVDR) was investigated. It was observed that the crystallite size, specific surface area, band gap energy and even photocatalytic activity was affected by the synergism occurring between cavitation effect and the surfactant/titania precursor weight ratio. The study yielded interesting great results that could be considered for further application of ultrasound to tailor mesoporous titania features via sol-gel soft template synthesis, against conventional sol-gel process.

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