The effects of macroporosity and stiffness of poly[(methyl vinyl ether)-alt-(maleic acid)] cross-linked egg white simulations of an aged extracellular matrix on the proliferation of ovarian cancer cells

RSC Advances ◽  
2016 ◽  
Vol 6 (50) ◽  
pp. 43892-43900 ◽  
Author(s):  
Zhenchao Guo ◽  
Tianzhu Zhang ◽  
Kun Fang ◽  
Jun Dou ◽  
Naizhen Zhou ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Extracellular Matrix ◽  
Cancer Cells ◽  
Vinyl Ether ◽  
Maleic Acid ◽  
Egg White ◽  
Ovarian Cancer Cells ◽  
Methyl Vinyl ◽  
Methyl Vinyl Ether

The effects of macroporosity and stiffness of P(MVE-alt-MA) cross-linked EW simulations of an aged ECM on the proliferation of cancer cells.

Thermal gravimetric analysis of in-situ crosslinked nanocellulose whiskers • poly(methyl vinyl ether-co-maleic acid) • polyethylene glycol

TAPPI Journal ◽  
2011 ◽  
Vol 10 (4) ◽  
pp. 29-33
Author(s):  
LEE A. GOETZ ◽  
AJI P. MATHEW ◽  
KRISTIINA OKSMAN ◽  
ARTHUR J. RAGAUSKAS
Keyword(s):  
Thermal Stability ◽  
Polyethylene Glycol ◽  
Vinyl Ether ◽  
Thermal Gravimetric Analysis ◽  
Maleic Acid ◽  
Gravimetric Analysis ◽  
Thermal Gravimetric ◽  
Methyl Vinyl ◽  
Methyl Vinyl Ether

The thermal stability and decomposition of in-situ crosslinked nanocellulose whiskers – poly(methyl vinyl ether-co-maleic acid) – polyethylene glycol formulations (PMVEMA-PEG), (25%, 50%, and 75% whiskers) – were investigated using thermal gravimetric analysis (TGA) methods. The thermal degradation behavior of the films varied according to the percent cellulose whiskers in each formulation. The presence of cellulose whiskers increased the thermal stability of the PMVEMA-PEG matrix.

scholarly journals Swelling kinetic study of poly(methyl vinyl ether-co-maleic acid) hydrogels as vehicle candidates for drug deliver

2018 ◽  
Vol 9 ◽  
Author(s):  
Rubhan Chandran ◽  
Eusni Mohd. Tohit ◽  
Mansor Ahmad ◽  
Tuan Mazlelaa Tuan Mahmood ◽  
Johnson Stanslas
Keyword(s):  
Kinetic Study ◽  
Vinyl Ether ◽  
Maleic Acid ◽  
Methyl Vinyl ◽  
Swelling Kinetic ◽  
Methyl Vinyl Ether

scholarly journals Mutual Expression of ALDH1A1, LOX, and Collagens in Ovarian Cancer Cell Lines as Combined CSCs- and ECM-Related Models of Drug Resistance Development

2018 ◽  
Vol 20 (1) ◽  
pp. 54 ◽  
Author(s):  
Karolina Sterzyńska ◽  
Andrzej Klejewski ◽  
Karolina Wojtowicz ◽  
Monika Świerczewska ◽  
Marta Nowacka ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Extracellular Matrix ◽  
Drug Resistance ◽  
Cancer Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Lysyl Oxidase ◽  
Resistant Cell ◽  
Pcr Analysis ◽  
Ovarian Cancer Cells

A major contributor leading to treatment failure of ovarian cancer patients is the drug resistance of cancer cell. CSCs- (cancer stem cells) and ECM (extracellular matrix)-related models of drug resistance are described as independently occurring in cancer cells. Lysyl oxidase (LOX) is another extracellular protein involved in collagen cross-linking and remodeling of extracellular matrix and has been correlated with tumor progression. The expression of LOX, COL1A2, COL3A1, and ALDH1A1 was performed in sensitive (A2780, W1) and resistant to paclitaxel (PAC) (A2780PR1 and W1PR2) and topotecan (TOP) (W1TR) cell lines at the mRNA (real-time PCR analysis) and protein level (Western blot and immunofluorescence analysis). The ALDH1A1 activity was measured with the ALDEFLUOR test and flow cytometry analysis. The protein expression in ovarian cancer tissues was determined by immunohistochemistry. We observed an increased expression of LOX and collagens in PAC and TOP resistant cell lines. Subpopulations of ALDH1A1 positive and negative cells were also noted for examined cell lines. Additionally, the coexpression of LOX with ALDH1A1 and COL1A2 with ALDH1A1 was observed. The expression of LOX, collagens, and ALDH1A1 was also detected in ovarian cancer lesions. In our study LOX, ALDH1A1 and collagens were found to be coordinately expressed by cells resistant to PAC (LOX, ALDH1A1, and COL1A2) or to TOP (LOX and ALDH1A1). This represents the study where molecules related with CSCs (ALDH1A1) and ECM (LOX, collagens) models of drug resistance are described as occurring simultaneously in ovarian cancer cells treated with PAC and TOP.

scholarly journals Synthesis of biotin‐targeted chitosan/poly (methyl vinyl ether‐ alt ‐maleic acid) copolymeric micelles for delivery of doxorubicin

2017 ◽  
Vol 11 (7) ◽  
pp. 843-851
Author(s):  
Jaleh Varshosaz ◽  
Ehsan Khabbazian ◽  
Farshid Hassanzadeh ◽  
Hojjat Sadeghi Aliabadi ◽  
Mahboobeh Rostami ◽  
...  
Keyword(s):  
Vinyl Ether ◽  
Maleic Acid ◽  
Methyl Vinyl ◽  
Methyl Vinyl Ether
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