Probing the interaction between cisplatin and the therapeutic monoclonal antibody trastuzumab

RSC Advances ◽  
2016 ◽  
Vol 6 (35) ◽  
pp. 29229-29236 ◽  
Author(s):  
Alessia Lasorsa ◽  
Maurizio Losacco ◽  
Rosa Maria Iacobazzi ◽  
Letizia Porcelli ◽  
Amalia Azzariti ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Cancer Therapy ◽  
Antigen Binding ◽  
Binding Region ◽  
Fc Fragment ◽  
Therapeutic Monoclonal Antibody

Cisplatin binds to the monoclonal antibody trastuzumab preferentially to the Fc fragment, leaving the antigen binding region unaffected. The two drugs are co-administered in cancer therapy.

Immunohistochemically detecting target antigens in patient biopsies for tailoring monoclonal antibody based cancer therapy

1999 ◽  
Vol 9 (1) ◽  
pp. 61-65 ◽  
Author(s):  
Nancy L. Smith ◽  
James L. Finley ◽  
Anne E. Wennerberg ◽  
Diane A. Semer ◽  
Kelly P. Kearse
Keyword(s):  
Monoclonal Antibody ◽  
Cancer Therapy

scholarly journals Distinct PD-L1 binding characteristics of therapeutic monoclonal antibody durvalumab

2017 ◽  
Vol 9 (1) ◽  
pp. 135-139 ◽  
Author(s):  
Shuguang Tan ◽  
Kefang Liu ◽  
Yan Chai ◽  
Catherine W.-H. Zhang ◽  
Shan Gao ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Binding Characteristics ◽  
Therapeutic Monoclonal Antibody

Detection and identification of a serine to arginine sequence variant in a therapeutic monoclonal antibody

2011 ◽  
Vol 879 (27) ◽  
pp. 2877-2884 ◽  
Author(s):  
Diya Ren ◽  
Jian Zhang ◽  
Ross Pritchett ◽  
Hongbin Liu ◽  
Jennifer Kyauk ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Sequence Variant ◽  
Therapeutic Monoclonal Antibody ◽  
Detection And Identification

Sculpting therapeutic monoclonal antibody N-glycans using endoglycosidases

2022 ◽  
Vol 72 ◽  
pp. 248-259
Author(s):  
Beatriz Trastoy ◽  
Jonathan J. Du ◽  
Mikel García-Alija ◽  
Chao Li ◽  
Erik H. Klontz ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Therapeutic Monoclonal Antibody

Therapeutic monoclonal antibody interference in electrophoretic and immunofixation techniques

2019 ◽  
Vol 493 ◽  
pp. S45-S46
Author(s):  
I. Šahinović ◽  
J. Sinčić-Petričević ◽  
V. Oršić-Frič ◽  
V. Borzan ◽  
J. Pavela ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Therapeutic Monoclonal Antibody

Monoclonal antibodies in cancer therapy.

1983 ◽  
Vol 1 (9) ◽  
pp. 582-590 ◽  
Author(s):  
R K Oldham
Keyword(s):  
Monoclonal Antibody ◽  
Clinical Trials ◽  
Monoclonal Antibodies ◽  
Cancer Therapy ◽  
Experimental Approach ◽  
Preliminary Evidence ◽  
Current Status ◽  
Experimental Animals ◽  
Specific Targeting ◽  
Specific Tumor

The need for improved specificity in cancer therapy is apparent. With the advent of monoclonal antibodies, the possibility of specifically targeted therapy is being considered. Early trials of monoclonal antibody in experimental animals and humans have indicated its ability to traffic to specific tumor sites and to localize on or around the tumor cells displaying antigens to which the antibody is directed. This evidence of specific targeting, along with preliminary evidence of therapeutic efficacy for monoclonal antibodies and immunoconjugates with drugs, toxins, and isotopes is encouraging. The current status of clinical trials with monoclonal antibodies is reviewed and an example of the experimental approach for the development of immunoconjugates in animal models is presented.

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