Preparation and characterization of a dual-receptor mesoporous silica nanoparticle–hyaluronic acid–RGD peptide targeting drug delivery system

RSC Advances ◽  
2016 ◽  
Vol 6 (46) ◽  
pp. 40427-40435 ◽  
Author(s):  
Haixing Xu ◽  
Zhihui Wang ◽  
Yan Li ◽  
Yufeng Guo ◽  
Huimin Zhou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Mesoporous Silica ◽  
Mesoporous Silica Nanoparticles ◽  
Silica Nanoparticle ◽  
Rgd Peptide ◽  
Mesoporous Silica Nanoparticle ◽  
System P ◽  
Peptide Targeting

Novel mesoporous silica nanoparticles conjugated with hyaluronic acid and RGD peptide were developed for dual-receptor mediated targeting drug delivery.

Metal-Phenolic Encapsulated Mesoporous Silica Nanoparticles for pH-Responsive Drug Delivery and Magnetic Resonance Imaging

2018 ◽  
Vol 232 (9-11) ◽  
pp. 1733-1740 ◽  
Author(s):  
Yan Chen ◽  
Juan Wang ◽  
Jianhua Liu ◽  
Lehui Lu
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Mesoporous Silica Nanoparticles ◽  
Silica Nanoparticle ◽  
Burst Release ◽  
Acidic Environment ◽  
Ph Responsive ◽  
Resonance Imaging ◽  
Mesoporous Silica Nanoparticle ◽  
Longitudinal Relaxivity

Abstract The anticancer drug doxorubicin (DOX) is locked in the mesoporous silica nanoparticle by coating FeIII-TA polymer, and its burst release can be achieved under acidic environment, along with the decreased longitudinal relaxivity. This nanoplatform shows great potential to monitoring the drug delivery process and the fate of the nanocarrier.

A Review on Application of Multifunctional Mesoporous Nanoparticles in Controlled Release of Drug Delivery

2014 ◽  
Vol 781 ◽  
pp. 17-24 ◽  
Author(s):  
Pragnesh N. Dave ◽  
Lakha V. Chopda
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Silica Nanoparticle ◽  
Disease Diagnosis ◽  
Ammonium Bromide ◽  
Composition Material ◽  
Mesoporous Silica Nanoparticle

In the early 1990s the discovery of the MCM-41 and the M41S family of mesoporous materials had open new era in the chemistry and biology. They have prominent application inbiotechnological, biomedical and heterogeneous catalysts. Mesoporous silica nanoparticles (MSNs) exhibit unique structural features like as their large surface areas, tunable pore sizes in nanometer and well-defined surface properties. MSN materials which are comprised of a honeycomb-like porous structure with hundreds of empty mesoporous channel that are able to encapsulate relatively large amounts of biomolecules. They are ideal candidate for constructing multifunctional materials that encapsulate a variety of functional nanostructured materials. Multifunctional MSN materials have become one of the most attractive areas in nanobiotechnology and nanomedicine for various disease diagnosis and therapy. Multifunctional MSN have been successfully developed as a multifunctional platform to deliver therapeutic and diagnostic agents. Multifunctional MSNs are a highly promising platform for intracellular controlled release of drugs. In this review we discuss the recent developments in design and fabrication of multifunctional mesoporous silica nanoparticles in as efficient drug delivery applications such as the site-specific delivery and intracellular controlled release of drugs.Abbreviations;APTES; 3-aminopropyl triethoxy sialne, ATP; Adenosine triphospahate, CD; cyclodextrinCPT; camptothecin, CS; Chitosan,CTAB; cyltrimethylammonium bromide,DNA; Deoxyribonucleic acid,DOX; doxorubicin,EDC; 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide,FD; fluorescein disodium,FSP;Fluroscent particle ,IBU;ibuprofen,MCM; mobil composition material, MPS; 3-trimethoxylsilyl propyl methacrylate, MS; mesoporous silica,MSN; mesoporous silica nanoparticle, MSNs; mesoporous silica nanoparticles,MSNP; mesoporous silica nanoparticle,NPS; nanoparticles;PFDTES;perfluorodecyltriethoxysilane, PAA; polyacrylic acid,PR;photo responsive,PMAA; polymethyl methacrylate,SBF; simulated body fluid,TEOS;tetraethyl orthosilicate,TUNA;Thio undecyl-tetraethyleneglycoestero-nitrobenzylethyldimethyl ammonium bromide.

Dual pH-responsive mesoporous silica nanoparticles for efficient combination of chemotherapy and photodynamic therapy

2015 ◽  
Vol 3 (23) ◽  
pp. 4707-4714 ◽  
Author(s):  
Xuemei Yao ◽  
Xiaofei Chen ◽  
Chaoliang He ◽  
Li Chen ◽  
Xuesi Chen
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
Silica Nanoparticle ◽  
Ph Responsive ◽  
Mesoporous Silica Nanoparticle

By metallo-supramolecular coordinated interaction between Zn-Por and histidine, a dual pH-responsive mesoporous silica nanoparticle (MSN)-based drug delivery system has been fabricated for synergistic chemo-photodynamic therapy.

A Dual-Responsive Mesoporous Silica Nanoparticle for Tumor-Triggered Targeting Drug Delivery

Small ◽  
2013 ◽  
Vol 10 (3) ◽  
pp. 591-598 ◽  
Author(s):  
Dong Xiao ◽  
Hui-Zhen Jia ◽  
Jing Zhang ◽  
Chen-Wei Liu ◽  
Ren-Xi Zhuo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticle ◽  
Mesoporous Silica Nanoparticle ◽  
Dual Responsive

scholarly journals Dy-DOTA integrated mesoporous silica nanoparticles as promising ultrahigh field magnetic resonance imaging contrast agents

Nanoscale ◽  
2018 ◽  
Vol 10 (45) ◽  
pp. 21041-21045 ◽  
Author(s):  
Xiao-Yu Zheng ◽  
Juan Pellico ◽  
Alexandr A. Khrapitchev ◽  
Nicola R. Sibson ◽  
Jason J. Davis
Keyword(s):  
Magnetic Resonance Imaging ◽  
Mesoporous Silica ◽  
Mesoporous Silica Nanoparticles ◽  
Silica Nanoparticle ◽  
Outer Sphere ◽  
Resonance Imaging ◽  
Mesoporous Silica Nanoparticle ◽  
Ultrahigh Field ◽  
Magnetic Resonance Imaging Contrast ◽  
Sphere Mechanism

Integrating Dy-DOTA motifs into mesoporous silica nanoparticle scaffolds significantly amplifies the ultrahigh field T2 relaxivity via a Curie outer-sphere mechanism.

Mesoporous silica nanoparticle based enzyme responsive system for colon specific drug delivery through guar gum capping

2017 ◽  
Vol 150 ◽  
pp. 352-361 ◽  
Author(s):  
Balmiki Kumar ◽  
Senthilguru Kulanthaivel ◽  
Animesh Mondal ◽  
Smruti Mishra ◽  
Biplab Banerjee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Guar Gum ◽  
Silica Nanoparticle ◽  
Specific Drug ◽  
Mesoporous Silica Nanoparticle ◽  
Colon Specific Drug Delivery
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