Facile synthesis of Gd(iii) metallosurfactant-functionalized carbon nanodots with high relaxivity as bimodal imaging probes

RSC Advances ◽  
2016 ◽  
Vol 6 (35) ◽  
pp. 29441-29447 ◽  
Author(s):  
Qin Zhu ◽  
Fei Pan ◽  
Yu Tian ◽  
Weijun Tang ◽  
Yuan Yuan ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Contrast Agents ◽  
Self Assembly ◽  
Carbon Nanodots ◽  
Facile Synthesis ◽  
Bimodal Imaging ◽  
High Relaxivity ◽  
Imaging Probes

Fluorescence and magnetic resonance (MR) dual-modal imaging contrast agents were prepared by the ionic self-assembly of carbon nanodots (CDs) and gadolinium(iii)-containing metallosurfactants (MS).

Self-Assembly of SiO2/Gd-DTPA-Polyethylenimine Nanocomposites as Magnetic Resonance Imaging Probes

2010 ◽  
Vol 10 (1) ◽  
pp. 540-548 ◽  
Author(s):  
Kui Luo ◽  
Jing Tian ◽  
Gang Liu ◽  
Jiayu Sun ◽  
Chunchao Xia ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Self Assembly ◽  
Resonance Imaging ◽  
Imaging Probes

scholarly journals Paramagnetic viral nanoparticles as potential high-relaxivity magnetic resonance contrast agents

2005 ◽  
Vol 54 (4) ◽  
pp. 807-812 ◽  
Author(s):  
Mark Allen ◽  
Jeff W. M. Bulte ◽  
Lars Liepold ◽  
Gautam Basu ◽  
Holly A. Zywicke ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Contrast Agents ◽  
High Relaxivity ◽  
Magnetic Resonance Contrast ◽  
Resonance Contrast ◽  
Viral Nanoparticles

Two Binuclear Nonionic Magnetic Resonance Contrast Agents with High Relaxivity

2018 ◽  
Vol 38 (7) ◽  
pp. 1779
Author(s):  
Hongshun Sun ◽  
Yulong Li ◽  
Hong Jiang ◽  
Cheng Guo ◽  
Linjiang Shen
Keyword(s):  
Magnetic Resonance ◽  
Contrast Agents ◽  
High Relaxivity ◽  
Magnetic Resonance Contrast ◽  
Resonance Contrast

Gadolinium complexes of macrocyclic diethylenetriamine-N-oxide pentaacetic acid-bisamide as highly stable MRI contrast agents with high relaxivity

2020 ◽  
Vol 49 (26) ◽  
pp. 8927-8932
Author(s):  
Kehan Xu ◽  
Na Xu ◽  
Beibei Zhang ◽  
Weijun Tang ◽  
Yun Ding ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Gadolinium Complexes ◽  
High Relaxivity ◽  
Magnetic Resonance Imaging Mri

Macrocyclic gadolinium(iii) complexes with hyphenated-amino-N-oxide (HAO) type ligand structures are designed as efficient magnetic resonance imaging (MRI) contrast agents (CAs) with high relaxivity and stability.

Are All Gadolinium-based Contrast Agents Similar? The Importance of High Stability, High Relaxivity and High Concentration

2009 ◽  
Vol 4 (2) ◽  
pp. 98 ◽  
Author(s):  
Nicoletta Anzalone ◽  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
High Stability ◽  
Physicochemical Characteristics ◽  
Resonance Imaging ◽  
Contributing Factors ◽  
High Concentration ◽  
High Relaxivity ◽  
The Stability

Gadolinium-based contrast agents (GBCAs) are commonly used to enhance image acquisition via magnetic resonance imaging, but they differ in their physicochemical characteristics and therefore their function. The stability, concentration and relaxivity of a GBCA can have a major impact on clinical efficacy. Stability is related to safety. GBCAs can be categorised into three stability classes: non-ionic linear agents, ionic linear agents and macrocyclic agents, in order of increasing stability. Relaxivity and concentration are contributing factors to the level of enhancement that can be achieved with any given GBCA. Gadobutrol, gadobenate and gadoxetic acid have relatively high relaxivities. Among these compounds, only gadobutrol is commercially available at a higher concentration of 1.0M, whereas the others are used at a standard concentration of 0.5M. With high stability, relaxivity and concentration, gadobutrol has been shown in a number of clinical studies to be safe while improving image enhancement with increased conspicuity and sensitivity over other commonly used GBCAs.

β-conjugation of gadolinium(III) DOTA complexes to zinc(II) porpholactol as potential multimodal imaging contrast agents

2014 ◽  
Vol 18 (10n11) ◽  
pp. 950-959 ◽  
Author(s):  
Xian-Sheng Ke ◽  
Juan Tang ◽  
Zi-Shu Yang ◽  
Jun-Long Zhang
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Aqueous Media ◽  
Resonance Imaging ◽  
Bimodal Imaging ◽  
Imaging Experiment ◽  
Meso Position ◽  
Magnetic Resonance Imaging Mri ◽  
Magnetic Resonance Imaging Experiment

Synthesis of two bimodal imaging agents consist of a hydrophobic zinc(II) tetrapentafluorophenylporpholactol core and a β-substituted hydrophilic Gd ( III ) DO3A (ZnLGd539) or DOTA (ZnLGd595) like moiety has been described (DO3A = 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid, DOTA = 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid). Through β-conjugation approach, the absorption at deep red region increases compared to traditional conjugation methods at meso-position. More importantly, these new complexes possess largely improved ionic relaxitivites relative to the sole Gd ( III ) magnetic resonance imaging (MRI) agents such as Gd ( III ) DO3A and Gd ( III ) DOTA like complexes. Combining the optical and magnetic resonance measurements in aqueous media, the largely enhanced r1 relaxivities was attributed to the aggregation of ZnLGd539 and ZnLGd595 in aqueous media. Furthermore, fluorescence and magnetic resonance imaging experiment showed that both ZnLGd539 and ZnLGd595 can be applied as potential bimodal imaging contrast agents. Finally, both compounds showed no dark cytotoxicity and good photocytotoxicity (IC50 = 1.73 ± 0.13 and 1.52 ± 0.10 μM for ZnLGd539 and ZnLGd595 respectively) on Hela cells.

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