Mesoporous silica nanoparticles (MSNs) as an efficient and reusable nanocatalyst for synthesis of β-amino ketones through one-pot three-component Mannich reactions

RSC Advances ◽  
2016 ◽  
Vol 6 (38) ◽  
pp. 32183-32188 ◽  
Author(s):  
Zahra Nasresfahani ◽  
Mohammad Zaman Kassaee ◽  
Mohammad Nejati-Shendi ◽  
Esmaiel Eidi ◽  
Qazale Taheri
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Mannich Reactions ◽  
One Pot

In this paper, mesoporous silica nanoparticles (MSNs) are introduced as an efficient nanocatalyst for synthesis of β-amino ketones.

scholarly journals Cytostatic and Cytotoxic Effects of Hollow-Shell Mesoporous Silica Nanoparticles Containing Magnetic Iron Oxide

Nanomaterials ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 2455
Author(s):  
Manuel Pérez-Garnes ◽  
Victoria Morales ◽  
Raul Sanz ◽  
Rafael A. García-Muñoz
Keyword(s):  
Iron Oxide ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
Target Cells ◽  
One Pot ◽  
Hollow Shell ◽  
Magnetic Iron Oxide ◽  
Model Drug

Among the different types of nanoparticles used in biomedical applications, Fe nanoparticles and mesoporous siliceous materials have been extensively investigated because of their possible theranostic applications. Here, we present hollow-shell mesoporous silica nanoparticles that encapsulate iron oxide and that are prepared using a drug-structure-directing agent concept (DSDA), composed of the model drug tryptophan modified by carbon aliphatic hydrocarbon chains. The modified tryptophan can behave as an organic template that allows directing the hollow-shell mesoporous silica framework, as a result of its micellisation and subsequent assembly of the silica around it. The one-pot synthesis procedure facilitates the incorporation of hydrophobically stabilised iron oxide nanoparticles into the hollow internal silica cavities, with the model drug tryptophan in the shell pores, thus enabling the incorporation of different functionalities into the all-in-one nanoparticles named mesoporous silica nanoparticles containing magnetic iron oxide (Fe3O4@MSNs). Additionally, the drug loading capability and the release of tryptophan from the silica nanoparticles were examined, as well as the cytostaticity and cytotoxicity of the Fe3O4@MSNs in different colon cancer cell lines. The results indicate that Fe3O4@MSNs have great potential for drug loading and drug delivery into specific target cells, thereby overcoming the limitations associated with conventional drug formulations, which are unable to selectively reach the sites of interest.

Constructing reduction-sensitive PEGylated NIRF mesoporous silica nanoparticles via a one-pot Passerini reaction for photothermal/chemo-therapy

2018 ◽  
Vol 54 (84) ◽  
pp. 11921-11924 ◽  
Author(s):  
Yu Zhu ◽  
Wenhai Lin ◽  
Xin Wang ◽  
Wei Zhang ◽  
Li Chen ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Disulfide Bonds ◽  
Mesoporous Silica Nanoparticles ◽  
Passerini Reaction ◽  
One Pot ◽  
Nirf Imaging ◽  
First Time

For the first time, we have obtained a multifunctional nanoplatform (MSN-BDP-PEG) containing disulfide bonds, BODIPY 5 and PEG-CHO via a one-pot Passerini reaction for chemotherapy, phototherapy and NIRF imaging.

Molecular Ionic Liquid Supported on Mesoporous Silica Nanoparticles-Imprinted Iron Metal: A Recyclable Heterogeneous Catalyst for One-Pot, Three-Component Synthesis of a Library of Benzodiazepines

2019 ◽  
Vol 16 (1) ◽  
pp. 136-144 ◽  
Author(s):  
Vajihe Nejadshafiee ◽  
Hossein Naeimi
Keyword(s):  
Ionic Liquid ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
One Pot ◽  
Environmental Friendliness ◽  
Iron Metal ◽  
Catalytic Cyclization ◽  
Recyclable Heterogeneous Catalyst ◽  
Mcm 41

Aim and Objective: A novel and convenient transformation for the synthesis of benzodiazepines has been developed via catalytic cyclization reaction using ionic liquid supported on mesoporous silica nanoparticles- imprinted iron metal (Fe-MCM-41-IL) as a recyclable catalyst under mild conditions. Materials and Methods: For preparation of Fe-MCM-41-IL, FeCl3·6H2O was added to a mixture of distilled water, CTAB and NaOH aqueous solution. The tetraethyl orthosilicate was dropped into the solution under stirring. The product was separated, washed, and dried. The solid product was collected and calcined. Then, to a solution of β-hydroxy-1,2,3-triazole in toluene, 3-chloropropyltrimethoxysilane was added and the mixture was refluxed. The Conc. H2SO4 was added dropwise into the above solution and stirred. For immobilization of IL onto Fe-MCM-41, the solution IL was added to Fe-MCM-41 and was refluxed for the production of the Fe- MCM-41. Following this, benzodiazepines were synthesized using Fe-MCM-41-IL as a catalyst. </P><P> Results: The Fe-MCM-41-IL was prepared and characterized by a different analysis. The activity of the prepared catalyst as the above described was tested in the model reaction of o-phenyldiamine, tetronic acid, and different aldehydes under room temperature in ethanol solvent. Also, the catalyst could be recovered for five cycles. Conclusion: We developed a novel nanocatalyst for the synthesis of benzodiazepines in excellent yields. Fe- MCM-41-IL as a catalyst has advantages such as: environmental friendliness, reusability and easy recovery of the catalyst using an external magnet.

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