Compressive mechanical properties and microstructure of PVA–HA hydrogels for cartilage repair

RSC Advances ◽  
2016 ◽  
Vol 6 (24) ◽  
pp. 20166-20172 ◽  
Author(s):  
Wenxu Li ◽  
Duo Wang ◽  
Wen Yang ◽  
Ying Song
Keyword(s):  
Mechanical Properties ◽  
Cartilage Repair ◽  
Vinyl Alcohol ◽  
Poly Vinyl Alcohol ◽  
Synthetic Method

In this paper, hydroxyapatite (HA) was deposited on poly(vinyl alcohol) (PVA) molecular chains by an in situ synthetic method.

scholarly journals In situ alignment of graphene nanoplatelets in poly(vinyl alcohol) nanocomposite fibers with controlled stepwise interfacial exfoliation

2019 ◽  
Vol 1 (7) ◽  
pp. 2510-2517 ◽  
Author(s):  
Weiheng Xu ◽  
Sayli Jambhulkar ◽  
Rahul Verma ◽  
Rahul Franklin ◽  
Dharneedar Ravichandran ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Electrical Conductivity ◽  
Vinyl Alcohol ◽  
Graphene Nanoplatelets ◽  
Poly Vinyl Alcohol ◽  
Graphene Nanoplatelet ◽  
Nanocomposite Fibers

Exfoliated and aligned continuous graphene nanoplatelet channels with enhanced mechanical properties and superior electrical conductivity.

Poly(vinyl alcohol)/graphene oxide nanocomposites prepared by in situ polymerization with enhanced mechanical properties and water vapor barrier properties

RSC Advances ◽  
2016 ◽  
Vol 6 (55) ◽  
pp. 49448-49458 ◽  
Author(s):  
Jiaojiao Ma ◽  
Ying Li ◽  
Xiande Yin ◽  
Yu Xu ◽  
Jia Yue ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Graphene Oxide ◽  
Vinyl Alcohol ◽  
In Situ Polymerization ◽  
Barrier Properties ◽  
Poly Vinyl Alcohol ◽  
Water Vapor Barrier ◽  
One Step ◽  
Polymerization Method

A novel and one-stepin situpolymerization method for preparing the poly(vinyl alcohol) (PVA)/graphene oxide (GO) nanocomposites.

scholarly journals Design and evaluation of nano-hydroxyapatite/poly(vinyl alcohol) hydrogels coated with poly(lactic-co-glycolic acid)/nano-hydroxyapatite/poly(vinyl alcohol) scaffolds for cartilage repair

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Weiping Su ◽  
Yihe Hu ◽  
Min Zeng ◽  
Mingqing Li ◽  
Shaoru Lin ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Double Layer ◽  
Cartilage Repair ◽  
Vinyl Alcohol ◽  
Glycolic Acid ◽  
Mechanical Load ◽  
Poly Vinyl Alcohol ◽  
Primary Role ◽  
Pva Hydrogel

Abstract Background Poly(vinyl alcohol) (PVA) hydrogels have been widely used in synthetic cartilage materials. However, limitations of PVA hydrogels such as poor biomechanics and limited cell ingrowth remain challenges in this field. Methods This work aimed to design novel nano-hydroxyapatite (nano-HA)/poly(vinyl alcohol) (PVA) hydrogels coated with a poly(lactic-co-glycolic acid) (PLGA)/nano-HA/PVA scaffold to counter the limitations of PVA hydrogels. The core, comprising nano-HA/PVA hydrogel, had the primary role of bearing the mechanical load. The peripheral structure, composed of PLGA/nano-HA/PVA, was designed to favor interaction with surrounding cartilage. Results The double-layer HA/PVA hydrogel coated with PLGA/HA/PVA scaffold was successfully prepared using a two-step molding method, and the mechanical properties and biocompatibility were characterized. The mechanical properties of the novel PLGA/HA/PVA scaffold modified HA/PVA hydrogel were similar to those of native cartilage and showed greater sensitivity to compressive stress than to tensile stress. Rabbit chondrocytes were seeded in the composites to assess the biocompatibility and practicability in vitro. The results showed that the peripheral component comprising 30 wt% PLGA/5 wt% HA/15 wt% PVA was most conducive to rabbit chondrocyte adhesion and proliferation. Conclusions The study indicated that the double-layer HA/PVA hydrogel coated with PLGA/HA/PVA scaffold has the potential for cartilage repair.

scholarly journals Novel Hydrogels of Chitosan and Poly (vinyl alcohol) Reinforced with Inorganic Particles of Bioactive Glass

Polymers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 691
Author(s):  
O. Sánchez-Aguinagalde ◽  
Ainhoa Lejardi ◽  
Emilio Meaurio ◽  
Rebeca Hernández ◽  
Carmen Mijangos ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Drug Release ◽  
Bioactive Glass ◽  
Vinyl Alcohol ◽  
Release Kinetics ◽  
The Body ◽  
Poly Vinyl Alcohol ◽  
X Ray Diffraction ◽  
Inorganic Particles ◽  
Release Studies

Chitosan (CS) and poly (vinyl alcohol) (PVA) hydrogels, a polymeric system that shows a broad potential in biomedical applications, were developed. Despite the advantages they present, their mechanical properties are insufficient to support the loads that appear on the body. Thus, it was proposed to reinforce these gels with inorganic glass particles (BG) in order to improve mechanical properties and bioactivity and to see how this reinforcement affects levofloxacin drug release kinetics. Scanning electron microscopy (SEM), X-ray diffraction (XRD), swelling tests, rheology and drug release studies characterized the resulting hydrogels. The experimental results verified the bioactivity of these gels, showed an improvement of the mechanical properties and proved that the added bioactive glass does affect the release kinetics.

scholarly journals Fabrication of Hybrid Nanofibers from Biopolymers and Poly (Vinyl Alcohol)/Poly (ε-Caprolactone) for Wound Dressing Applications

Polymers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 2104
Author(s):  
Sibusiso Alven ◽  
Blessing Atim Aderibigbe
Keyword(s):  
Mechanical Properties ◽  
Wound Healing ◽  
Vinyl Alcohol ◽  
Wound Dressing ◽  
Chronic Wounds ◽  
Cellular Adhesion ◽  
Wound Dressings ◽  
Poly Vinyl Alcohol ◽  
High Porosity ◽  
Hybrid Nanofibers

The management of chronic wounds is challenging. The factors that impede wound healing include malnutrition, diseases (such as diabetes, cancer), and bacterial infection. Most of the presently utilized wound dressing materials suffer from severe limitations, including poor antibacterial and mechanical properties. Wound dressings formulated from the combination of biopolymers and synthetic polymers (i.e., poly (vinyl alcohol) or poly (ε-caprolactone) display interesting properties, including good biocompatibility, improved biodegradation, good mechanical properties and antimicrobial effects, promote tissue regeneration, etc. Formulation of these wound dressings via electrospinning technique is cost-effective, useful for uniform and continuous nanofibers with controllable pore structure, high porosity, excellent swelling capacity, good gaseous exchange, excellent cellular adhesion, and show a good capability to provide moisture and warmth environment for the accelerated wound healing process. Based on the above-mentioned outstanding properties of nanofibers and the unique properties of hybrid wound dressings prepared from poly (vinyl alcohol) and poly (ε-caprolactone), this review reports the in vitro and in vivo outcomes of the reported hybrid nanofibers.

Preparation of Polyurethane-Poly (Vinyl Alcohol) / Chitosan Blend Nanofiber Nonwovens by Coelectrospinning

2012 ◽  
Vol 602-604 ◽  
pp. 157-160
Author(s):  
Wei Min Kang ◽  
Jing Yan ◽  
Bo Wen Cheng
Keyword(s):  
Mechanical Properties ◽  
Vinyl Alcohol ◽  
Diameter Distribution ◽  
Poly Vinyl Alcohol ◽  
Technical Parameters ◽  
The Ideal

Polyurethane-poly (vinyl alcohol)/chitosan (PU-PVA/CS) blend nanofiber nonwovens were successfully prepared by coelectrospinning in this paper. The morphology, diameter and structure of the electrospun nanomaterials were examined by SEM and FITR, and their mechanical properties were tested. The diameter distribution of the nanofibers was measured by Image-Pro Plus. The results show that the ideal nanofibers with the diameter in 50-350 nm can be obtained with the proper technical parameters of PU and PVA/CS nanofibers as follows: the spinning voltage at 30 kV and 40 kV, the extruding speed at 6 mL/h and 0.5 ml/h, the collecting distance at 150 mm and 200 mm, respectively.

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