Synthesis of decahydropyrrolo[1,2-a]tetrazolo[1,5-d]pyrazines via Strecker reaction and intramolecular [3+2] cycloaddition

RSC Advances ◽  
2016 ◽  
Vol 6 (35) ◽  
pp. 29783-29793 ◽  
Author(s):  
Shakil N. Afraj ◽  
Chinpiao Chen ◽  
Gene-Hsian Lee
Keyword(s):  
Efficient Method ◽  
Strecker Reaction ◽  
Catalyst Free

An efficient method for synthesizing a series of novel (5aS,10R)-10-aryl-5,5a,6,7,8,10-hexahydropyrrolo[1,2-a]tetrazolo[1,5-d]pyrazines by using a catalyst-free three-component Strecker reaction followed by an intramolecular [3+2] cycloaddition.

Novel One-pot Synthesis of Pyranocarbazole Derivatives via an Isocyanide-based Three-component Reaction

2020 ◽  
Vol 17 ◽  
Author(s):  
Visarapu Malathi ◽  
Pedavenkatagari Narayana Reddy ◽  
Pannala Padmaja
Keyword(s):  
Efficient Method ◽  
Atom Economy ◽  
Reaction Conditions ◽  
One Pot ◽  
Catalyst Free ◽  
One Pot Synthesis ◽  
Three Component Reaction ◽  
High Yields

Abstract:: An efficient method has been developed for the synthesis of new pyrano[3,2-c] and pyrano[3,2-a]carbazole de-rivatives via a three component reaction of 4-hydroxycarbazole or 2-hydroxycarbazole, isocyanides, and dialkylacetylenedi-carboxylates. Noteworthy features of this protocol include mild reaction conditions, catalyst-free, high atom-economy and high yields.

Transition-metal-free access to 2-aminopyridine derivatives from 2-fluoropyridine and acetamidine hydrochloride

2018 ◽  
Vol 16 (41) ◽  
pp. 7564-7567 ◽  
Author(s):  
Yibiao Li ◽  
Shuo Huang ◽  
Chunshu Liao ◽  
Yan Shao ◽  
Lu Chen
Keyword(s):  
Transition Metal ◽  
Nucleophilic Substitution ◽  
Efficient Method ◽  
Free Access ◽  
Metal Free ◽  
Catalyst Free ◽  
Hydrolysis Of

Under catalyst-free conditions, an efficient method for the synthesis of 2-aminopyridine derivatives through the nucleophilic substitution and hydrolysis of 2-fluoropyridine and acetamidine hydrochloride has been developed.

Catalyst-Free Multicomponent Strecker Reaction in Acetonitrile.

ChemInform ◽  
2006 ◽  
Vol 37 (12) ◽  
Author(s):  
Ricardo Martinez ◽  
Diego J. Ramon ◽  
Miguel Yus
Keyword(s):  
Strecker Reaction ◽  
Catalyst Free

Synthesis of functionalized tetrahydropyridazines via catalyst-free self [4 + 2] cycloaddition of in situ generated 1,2-diaza-1,3-dienes

RSC Advances ◽  
2016 ◽  
Vol 6 (66) ◽  
pp. 61680-61685 ◽  
Author(s):  
Zhimin Zhang ◽  
Li Zhang ◽  
Qingqing Chen ◽  
Tao Lu ◽  
Qingfa Zhou
Keyword(s):  
Drug Discovery ◽  
Efficient Method ◽  
Catalyst Free

An efficient method for the synthesis of structurally diverse functionalized tetrahydropyridazines via self [4 + 2] cycloaddition of in situ generated 1,2-diaza-1,3-dienes was developed, which may play an important role in drug discovery.

scholarly journals An efficient Passerini tetrazole reaction (PT-3CR)

2016 ◽  
Vol 18 (13) ◽  
pp. 3718-3721 ◽  
Author(s):  
Ajay L. Chandgude ◽  
Alexander Dömling
Keyword(s):  
Efficient Method ◽  
Catalyst Free ◽  
Three Component Reaction

A sonication accelerated, catalyst free, simple, high yielding and efficient method for the Passerini-type three-component reaction (PT-3CR) has been developed.

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