Synthesis of tricyclic 3-hydroxyisoindolin-1-ones via triethylamine-catalyzed domino reactions of electron-deficient alkynes with phthalimidomalonate derivatives

2017 ◽  
Vol 4 (1) ◽  
pp. 119-123 ◽  
Author(s):  
Li Zhang ◽  
Beichen Zhang ◽  
Teng Jiang ◽  
Tao Lu ◽  
Qingfa Zhou
Keyword(s):  
Domino Reaction ◽  
Domino Reactions ◽  
Mild Conditions ◽  
Activated Alkynes

A triethylamine-catalyzed domino reaction between phthalimidomalonate derivatives and activated alkynes has been developed under mild conditions.

A base-catalyzed domino reaction between isoindigos and α-alkylidene succinimides—convenient preparation of highly steric bispirooxindoles

2020 ◽  
Vol 18 (46) ◽  
pp. 9511-9515
Author(s):  
Chen-Yi Li ◽  
Min Xiang ◽  
Xiang-Jia Song ◽  
Ying Zou ◽  
Zhi-Cheng Huang ◽  
...  
Keyword(s):  
Domino Reaction ◽  
Mild Conditions ◽  
Convenient Preparation

A new Cs2CO3-catalyzed Michael–Michael domino reaction between isoindigos and α-alkylidene succinimides has been disclosed, and a series of highly steric bispirooxindoles with potential bioactive activities have been prepared under mild conditions.

Are fermentation products promising feedstock for high-density bio-fuel? domino reactions for upgrading aqueous acetone–butanol–ethanol mixtures

2020 ◽  
Vol 22 (18) ◽  
pp. 6137-6147
Author(s):  
Yahui Gong ◽  
Pingzhou Wang ◽  
Cai Wu ◽  
Jie Wang ◽  
Chun Shen
Keyword(s):  
Aqueous Acetone ◽  
High Density ◽  
Domino Reaction ◽  
Domino Reactions ◽  
Fermentation Products ◽  
Acetone Butanol Ethanol

Upgrading aqueous acetone–butanol–ethanol mixtures to high-density bio-fuels is realized via the three-step domino reaction in a green way.

Convenient and efficient synthesis of disubstituted piperazine derivatives by catalyst-free, atom-economical and tricomponent domino reactions

RSC Advances ◽  
2015 ◽  
Vol 5 (14) ◽  
pp. 10768-10772 ◽  
Author(s):  
Hong-Ru Dong ◽  
Zi-Bao Chen ◽  
Rong-Shan Li ◽  
Heng-Shan Dong ◽  
Zhi-Xiang Xie
Keyword(s):  
Free Atom ◽  
Domino Reactions ◽  
Efficient Synthesis ◽  
One Pot ◽  
Diversity Oriented Synthesis ◽  
Mild Conditions ◽  
Catalyst Free ◽  
Piperazine Derivatives ◽  
High Yields

One-pot, atom-economical, catalyst-free and tri-component domino reactions are applied to diversity-oriented synthesis (DOS) of disubstituted piperazine derivatives under mild conditions with moderate to high yields.

scholarly journals First Zinc Bromide Promoted Annulative Domino Reactions between Enamines and Cyclic Morita–Baylis–Hillman Alcohols: Synthesis of N,O-Ketals

Synlett ◽  
2020 ◽  
Vol 31 (13) ◽  
pp. 1282-1286
Author(s):  
Farhat Rezgui ◽  
Ghalia Bouhalleb ◽  
Ahmed Meddeb ◽  
Noura Fakhar Bourguiba ◽  
Julien Legros ◽  
...  
Keyword(s):  
Nucleophilic Addition ◽  
Conjugate Addition ◽  
Domino Reaction ◽  
Domino Reactions ◽  
Zinc Bromide ◽  
Iminium Ion

A new efficient ZnBr2-mediated annulative domino reaction between enamines and cyclic Morita–Baylis–Hillman (MBH) alcohols is disclosed. The process involves a tandem sequence (intermolecular conjugate addition of enamines to MBH alcohols and intramolecular nucleophilic addition of the hydroxyl moiety to the transiently generated iminium ion), affording the corresponding N,O-ketals diastereoselectively in good yields.

Gold-catalyzed domino reactions of alkynol and p-quinone methides: divergent synthesis of fused- and spiro-ketals

2020 ◽  
Vol 7 (6) ◽  
pp. 856-861 ◽  
Author(s):  
Wenxiu Mao ◽  
Shiquan Lin ◽  
Liang Zhang ◽  
Haifeng Lu ◽  
Jiong Jia ◽  
...  
Keyword(s):  
Domino Reaction ◽  
Domino Reactions ◽  
Quinone Methides

A gold-catalyzed domino reaction of alkynyl alcohols and p-quinone methides to obtain divergent fused- and spiro-ketals has been developed.

Stereoselective Aminoiodination of Activated Alkynes with Organoiodine(III) Reagents and Amines via Multiple-Site Functionalization: Access to Iodinated Enamines and N-Aryl Indoles

2019 ◽  
Author(s):  
sagar arepally ◽  
Narenderreddy Katta ◽  
Ajoy Chamuah ◽  
Sharada Duddu. S
Keyword(s):  
Hydrogen Bonding ◽  
Steric Hindrance ◽  
Single Step ◽  
Multiple Site ◽  
Aryl Group ◽  
Mild Conditions ◽  
Reaction Proceeds ◽  
Activated Alkynes ◽  
Acidic Conditions ◽  
High Stereoselectivity

<p>A stereoselective aminoiodination of activated alkynes with PhI(OAc)<sub>2</sub> and amines <i>via</i> multiple-site functionalization to afford (<i>Z</i>)diethyl 2-(diphenylamino)-3-iodomaleate derivatives with superior yields has been described. The key feature of this reaction is the incorporation of iodide and aryl group concurrently in the same molecule in a stereoselective manner by employing PhI(OAc)<sub>2</sub> as electrophilic reagent as well as iodide and aryl group source. The high stereoselectivity of the reaction can be explained based on the structure of the possible intermediates, the conformations of which controlled by the hydrogen bonding, steric hindrance and electrostatic attractions. This reaction proceeds under mild conditions, providing various dialkyl 2-(diphenylamino)-3-iodomaleates by a single operation starting from activated alkynes. The robustness of our strategy is revealed by making of bis (dialkyl 2-(diphenylamino)-3-iodomaleate) derivatives involving formation of four new C-N bonds and two C-I bonds with a single step. The synthesized inactive 3° enamines (dialkyl 2-(diphenylamino)-3-iodomaleates) could be further transformed into highly substituted indoles via Pd catalyzed C-H and C-I activation under non-acidic conditions. </p><br>

ChemInform Abstract: The First Example of 4,7,8,9-Tetrahydrothieno-[2,3-d]azocine Synthesis by Domino Reaction of 4-Aryl-4,5,6,7-tetrahydrothieno[3,2-c]pyridines with Activated Alkynes.

ChemInform ◽  
2015 ◽  
Vol 46 (26) ◽  
pp. no-no
Author(s):  
L. G. Voskressensky ◽  
T. N. Borisova ◽  
T. M. Chervyakova ◽  
M. D. Matveeva ◽  
D. V. Galaktionova ◽  
...  
Keyword(s):  
Domino Reaction ◽  
Activated Alkynes

Domino Reactions of 1-Aroyl-3,4-dihydroisoquinolines with α,β-Unsaturated Aldehydes

Synthesis ◽  
2017 ◽  
Vol 49 (23) ◽  
pp. 5251-5257 ◽  
Author(s):  
Maria Matveeva ◽  
Tatiana Borisova ◽  
Alexander Titov ◽  
Lada Anikina ◽  
Svetlana Dyachenko ◽  
...  
Keyword(s):  
Microwave Irradiation ◽  
Domino Reaction ◽  
Domino Reactions ◽  
Efficient Synthesis ◽  
Unsaturated Aldehydes

An efficient synthesis of pyrrolo[2,1-a]isoquinolines by a domino reaction from a variety of 3,4-dihydropyrrolo[2,1-a]isoquinolines and α,β-unsaturated aldehydes in the absence of catalyst in good yields under microwave irradiation, is reported.

Synthesis of penta- and tetra-cyclic cage-like compounds and dispiro heterocycles through microwave-assisted solvent-free multi-component domino reactions

2017 ◽  
Vol 41 (19) ◽  
pp. 11009-11015 ◽  
Author(s):  
Seeni Maharani ◽  
Sundaravel Vivek Kumar ◽  
Abdulrahman I. Almansour ◽  
Raju Suresh Kumar ◽  
Anitha Kandasamy ◽  
...  
Keyword(s):  
Solvent Free ◽  
Domino Reaction ◽  
Domino Reactions ◽  
Microwave Assisted

Novel penta- and tetra-cyclic cage-like compounds and dispiro heterocycles were obtained as a result of a microwave-assisted three-component domino reaction.

scholarly journals “On-water” synthesis of novel trisubstituted 1,3-thiazolesviamicrowave-assisted catalyst-free domino reactions

RSC Advances ◽  
2014 ◽  
Vol 4 (71) ◽  
pp. 37889-37899 ◽  
Author(s):  
Shaik Karamthulla ◽  
Suman Pal ◽  
Md. Nasim Khan ◽  
Lokman H. Choudhury
Keyword(s):  
Aqueous Media ◽  
Domino Reaction ◽  
Domino Reactions ◽  
Catalyst Free

A clean, efficient and catalyst-free multicomponent domino reaction of arylglyoxals, cyclic 1,3-dicarbonyls and thioamides in aqueous media under microwave conditions is reported.

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