A practical protocol for the synthesis of bibenzyls via C(sp3)–H activation of methyl arenes under metal-free conditions

2017 ◽  
Vol 4 (1) ◽  
pp. 147-150 ◽  
Author(s):  
Promod Kumar ◽  
Tirumaleswararao Guntreddi ◽  
Rahul Singh ◽  
Krishna Nand Singh
Keyword(s):  
Environmentally Benign ◽  
Atom Economy ◽  
Metal Free

A variety of bibenzyl derivatives have been synthesized with excellent atom economy via C(sp3)–H–C(sp3)–H coupling of readily available methyl arenes using K2S2O8 under metal-free and environmentally benign conditions.

Electrochemical Oxidative Cyclization of Alkenes, Boronic Acids, and Dichalcogenides to Access Chalcogenated Boronic Esters and 1,3-Diols

2021 ◽  
Author(s):  
Changfeng Huang ◽  
Jijing Hu ◽  
Guangxian Chen ◽  
Minjian Wu ◽  
Hua Cao ◽  
...  
Keyword(s):  
Boronic Acids ◽  
Oxidative Cyclization ◽  
Environmentally Benign ◽  
Allylic Alcohols ◽  
Efficient Manner ◽  
Metal Free ◽  
Boronic Esters

A sustainable, environmentally benign electrochemical oxidative three-component cyclization of allylic alcohols, boronic acids, and dichalcogenides under metal-free and oxidant-free conditions has been developed, which provides an efficient manner for the...

Green synthesis of benzoimidazopyrimidine, benzimidazoloquinazolinone, triazolopyrimidine and triazoloquinazolinone derivatives catalyzed by oxalic acid dihydrate

2021 ◽  
Vol 18 ◽  
Author(s):  
Seyed Sajad Sajadikhah ◽  
Bagher Liravi-Deylami
Keyword(s):  
Oxalic Acid ◽  
Green Synthesis ◽  
Column Chromatography ◽  
Catalytic Amount ◽  
Atom Economy ◽  
One Pot ◽  
Oxalic Acid Dihydrate ◽  
Metal Free ◽  
Solvent Free Conditions ◽  
Simple Filtration

: Benzoimidazopyrimidine, benzimidazoloquinazolinone, triazolopyrimidine, and triazoloquinazolinone derivatives were synthesized via a one-pot multi-component reaction in the presence of a catalytic amount of oxalic acid dihydrate. The reactions were performed in the mixture of EtOH: H2O or under solvent-free conditions as green media. The advantageous features of these methodologies are inexpensive starting materials and catalyst, high atom economy and good yields, and metal-free synthesis. Moreover, all the products were obtained by simple filtration with no need for column chromatography or tedious separation procedures, which is very important in terms of reducing environmental pollutions.

scholarly journals Nitrosonium ion catalysis: aerobic, metal-free cross-dehydrogenative carbon–heteroatom bond formation

2018 ◽  
Vol 54 (92) ◽  
pp. 13022-13025 ◽  
Author(s):  
Luis Bering ◽  
Laura D’Ottavio ◽  
Giedre Sirvinskaite ◽  
Andrey P. Antonchick
Keyword(s):  
Bond Formation ◽  
Environmentally Benign ◽  
Reaction Conditions ◽  
Metal Free ◽  
Dehydrogenative Coupling ◽  
Nitrosonium Ion

Catalytic cross-dehydrogenative coupling of heteroarenes with thiophenols and phenothiazines has been developed under mild and environmentally benign reaction conditions.

scholarly journals Metal-free synthesis of phosphinoylchroman-4-ones via a radical phosphinoylation–cyclization cascade mediated by K2S2O8

2020 ◽  
Vol 16 ◽  
pp. 1974-1982
Author(s):  
Qiang Liu ◽  
Weibang Lu ◽  
Guanqun Xie ◽  
Xiaoxia Wang
Keyword(s):  
Phosphine Oxide ◽  
Environmentally Benign ◽  
Metal Free

A variety of chroman-4-ones bearing phosphine oxide motifs were conveniently synthesized from readily available diphenylphosphine oxides and alkenyl aldehydes via a metal-free tandem phosphinoylation/cyclization protocol. The reaction utilizes K2S2O8 as oxidant and proceeds in DMSO/H2O at environmentally benign conditions with a broad substrate scope and afforded the title compounds in moderate yields.

scholarly journals Highly Efficient Synthesis of Hindered 3-Azoindoles via Metal-Free C–H Functionalization of Indoles

Synthesis ◽  
2020 ◽  
Vol 52 (04) ◽  
pp. 574-580
Author(s):  
Nicolas Jacob ◽  
Lucas Guillemard ◽  
Joanna Wencel-Delord
Keyword(s):  
Steric Hindrance ◽  
Room Temperature ◽  
Efficient Synthesis ◽  
Atom Economy ◽  
Photochromic Compounds ◽  
Metal Free ◽  
Highly Efficient ◽  
Simple Protocol ◽  
Potential Applications

Although 3-azoindoles have recently emerged as an appealing family of photoswitch molecules, the synthesis of such compounds has been poorly covered in the literature. Herein a high-yielding and operationally simple protocol is reported allowing the synthesis of 3-azoindoles, featuring important steric hindrance around the azo motif. Remarkably, this C–H coupling is characterized by excellent atom economy and occurs under metal-free conditions, at room temperature, and within few minutes, delivering the expected products in excellent yields (quantitatively in most of the cases). Accordingly, a library of new molecules, with potential applications as photochromic compounds, is prepared.

Base- and metal-free decarboxylative aldol reaction of β-ketoacids with glyoxylate hydrates and glyoxal monohydrates in water

2016 ◽  
Vol 18 (24) ◽  
pp. 6609-6617 ◽  
Author(s):  
Nan Ren ◽  
Jing Nie ◽  
Jun-An Ma
Keyword(s):  
Aldol Reaction ◽  
Environmentally Benign ◽  
Metal Free

An environmentally benign decarboxylative aldol reaction of β-ketoacids with glyoxylate and glyoxal monohydrates in water is reported.

Transition-metal-free and organic solvent-free conversion of N-substituted 2-aminobiaryls into corresponding carbazoles via intramolecular oxidative radical cyclization induced by peroxodisulfate

2017 ◽  
Vol 19 (24) ◽  
pp. 5854-5861 ◽  
Author(s):  
Palani Natarajan ◽  
Priya Priya ◽  
Deachen Chuskit
Keyword(s):  
Transition Metal ◽  
Organic Solvent ◽  
Radical Cyclization ◽  
Solvent Free ◽  
Environmentally Benign ◽  
Metal Free ◽  
Benign Synthesis ◽  
Oxidative Radical Cyclization

An atom-economical and environmentally benign synthesis of N-substituted carbazoles is described. This methodology afforded products in 90–120 minutes.

scholarly journals Metal-free oxidative coupling of arylmethylamines with indoles: a simple, environmentally benign approach for the synthesis of 3,3′-bis(indolyl)methanes

RSC Advances ◽  
2020 ◽  
Vol 10 (39) ◽  
pp. 23254-23262
Author(s):  
Vikas D. Kadu ◽  
Sankala Naga Chandrudu ◽  
Mahesh G. Hublikar ◽  
Dattatraya G. Raut ◽  
Raghunath B. Bhosale
Keyword(s):  
Molecular Oxygen ◽  
Oxidative Coupling ◽  
Environmentally Benign ◽  
Metal Free

The efficient metal-free oxidative coupling of arylmethylamines with indoles has been developed using molecular oxygen as a green oxidant towards a novel rout of 3,3′-bis(indolyl)methanes (BIMs) synthesis.

An Environment-friendly Synthesis of Piperonal Chalcones and Their Cytotoxic and Antioxidant Evaluation

2020 ◽  
Vol 17 (2) ◽  
pp. 138-144 ◽  
Author(s):  
Sanal Dev ◽  
Della Grace Thomas Parambi ◽  
Bency Baby ◽  
Githa Elizabeth Mathew ◽  
Hendawy Omnia Magdy ◽  
...  
Keyword(s):  
Hepg2 Cells ◽  
Antioxidant Activities ◽  
Environmentally Benign ◽  
Cytotoxic Action ◽  
Atom Economy ◽  
Environment Friendly ◽  
Antioxidant Evaluation ◽  
Ic50 Values ◽  
Ft Ir ◽  
Mcf 7

Background: Grindstone technique has been widely used as an efficient, consistent, more environmentally benign, solvent-free protocol for the preparation of many compounds with higher atom economy. Methods: A series of fourteen piperonal chalcone compounds were synthesized by this method and characterized by physical and spectral data (FT-IR, 1H NMR, Mass and elemental analysis). All chalcones were evaluated for their cytotoxic action against the cancer cell lines, MCF-7 and HepG2. One 2-pyridyl-substituted compound 14 with IC50 values 17.4±0.2 towards MCF-7 and 15.4±0.6µmol L-1 towards HepG2 cells. Results: The results demonstrated that the cytotoxic activity of 2-pyridyl-substituted compound shown higher activity as compared with the standard cisplatin towards HepG2 cells. Conclusion: Compound 14 showed good antioxidant activities in the DPPH test and H2O2 assay (IC50 = 17.23± 33/µg/mL and 20.17± 0.33µg/mL) when compared with the standard ascorbic acid (IC50=µg/mL 18.26 ± 0.22and 21.66± 1.06 µg/mL).

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