AIEgen-functionalised mesoporous silica nanoparticles as a FRET donor for monitoring drug delivery

2017 ◽  
Vol 4 (3) ◽  
pp. 468-472 ◽  
Author(s):  
Duo Wang ◽  
Jie Chen ◽  
Li Ren ◽  
Qinglan Li ◽  
Dongdong Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cell Imaging ◽  
Mesoporous Silica Nanoparticles ◽  
Release Process ◽  
Monitoring Drug

AIEgen-functionalised mesoporous silica nanoparticles can be used for cell imaging and monitoring the drug release process by different emission colours based on the FRET mechanism.

Monitoring of “on-demand” drug release using dual tumor marker mediated DNA-capped versatile mesoporous silica nanoparticles

2017 ◽  
Vol 53 (62) ◽  
pp. 8755-8758 ◽  
Author(s):  
Song Wang ◽  
Fei Liu ◽  
Xiang-Ling Li
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Tumor Marker ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
On Demand ◽  
Controllable Release ◽  
Internal Stimulus

We constructed a versatile drug delivery system using dual internal stimulus, achieving controllable release and monitoring simultaneously.

scholarly journals An aptamer-targeting photoresponsive drug delivery system using “off–on” graphene oxide wrapped mesoporous silica nanoparticles

Nanoscale ◽  
2015 ◽  
Vol 7 (14) ◽  
pp. 6304-6310 ◽  
Author(s):  
Yuxia Tang ◽  
Hao Hu ◽  
Molly Gu Zhang ◽  
Jibin Song ◽  
Liming Nie ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Cancer Therapy ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
Targeted Cancer Therapy

A photoresponsive drug delivery system was developed for light-mediated drug release and aptamer-targeted cancer therapy.

scholarly journals Live-Cell Imaging of Colloidal Mesoporous Silica Nanoparticles for Drug Delivery: Drug Loading, Pore Sealing and Controlled Release

2011 ◽  
Vol 100 (3) ◽  
pp. 600a
Author(s):  
Anna M. Sauer ◽  
Axel Schlossbauer ◽  
Valentina Cauda ◽  
Hanna Engelke ◽  
Christian Argyo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Live Cell Imaging ◽  
Cell Imaging ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
Live Cell ◽  
Pore Sealing

scholarly journals Mesoporous silica–chondroitin sulphate hybrid nanoparticles for targeted and bio-responsive drug delivery

2015 ◽  
Vol 39 (3) ◽  
pp. 1754-1760 ◽  
Author(s):  
Krishna Radhakrishnan ◽  
Jasaswini Tripathy ◽  
Akshay Datey ◽  
Dipshikha Chakravortty ◽  
Ashok M. Raichur
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Chondroitin Sulphate ◽  
Mesoporous Silica Nanoparticles ◽  
Hybrid Nanoparticles ◽  
Intracellular Degradation

A polysaccharide based gatekeeper is attached to seal the nanopores of drug mesoporous silica nanoparticles, which facilitates uptake by cancer cells and undergoes intracellular degradation to initiate drug release.

Smart mesoporous silica nanoparticles gated by pillararene-modified gold nanoparticles for on-demand cargo release

2016 ◽  
Vol 52 (95) ◽  
pp. 13775-13778 ◽  
Author(s):  
Xin Wang ◽  
Li-Li Tan ◽  
Xi Li ◽  
Nan Song ◽  
Zheng Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Release ◽  
On Demand

A new drug delivery system, based on mesoporous silica nanoparticles gated by carboxylatopillar[5]arene-modified gold nanoparticles, has been fabricated for controlled drug release.

scholarly journals Influence of the Surface Functionalization on the Fate and Performance of Mesoporous Silica Nanoparticles

Nanomaterials ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 916 ◽  
Author(s):  
Miguel Gisbert-Garzarán ◽  
María Vallet-Regí
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Textural Properties ◽  
Stimuli Responsive ◽  
Biological Barriers ◽  
And Performance ◽  
Localized Drug Delivery

Mesoporous silica nanoparticles have been broadly applied as drug delivery systems owing to their exquisite features, such as excellent textural properties or biocompatibility. However, there are various biological barriers that prevent their proper translation into the clinic, including: (1) lack of selectivity toward tumor tissues, (2) lack of selectivity for tumoral cells and (3) endosomal sequestration of the particles upon internalization. In addition, their open porous structure may lead to premature drug release, consequently affecting healthy tissues and decreasing the efficacy of the treatment. First, this review will provide a comprehensive and systematic overview of the different approximations that have been implemented into mesoporous silica nanoparticles to overcome each of such biological barriers. Afterward, the potential premature and non-specific drug release from these mesoporous nanocarriers will be addressed by introducing the concept of stimuli-responsive gatekeepers, which endow the particles with on-demand and localized drug delivery.

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