Well-defined podophyllotoxin polyprodrug brushes: preparation via RAFT polymerization and evaluation as drug carriers

2017 ◽  
Vol 8 (5) ◽  
pp. 901-909 ◽  
Author(s):  
Yifei Guo ◽  
Chunying Hao ◽  
Xiangkang Wang ◽  
Yanna Zhao ◽  
Meihua Han ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Raft Polymerization ◽  
Triethylene Glycol ◽  
Drug Carriers ◽  
Glycol Methacrylate ◽  
Hydrophobic Monomer ◽  
Methacrylate Copolymers

Novel poly(triethylene glycol methacrylate)-b-poly(podophyllotoxin methacrylate) copolymers (PTP) with a well-defined structure were designed and synthesized by direct RAFT polymerization with the hydrophobic monomer derivative from the anticancer drug podophyllotoxin.

Advances in Nanoparticles as Anticancer Drug Delivery Vector: Need of this Century

2020 ◽  
Vol 26 (15) ◽  
pp. 1637-1649 ◽  
Author(s):  
Imran Ali ◽  
Sofi D. Mukhtar ◽  
Heyam S. Ali ◽  
Marcus T. Scotti ◽  
Luciana Scotti
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Medical Science ◽  
Drug Carriers ◽  
Anticancer Drug Delivery ◽  
Ph Values ◽  
Delivery Vector ◽  
Future Challenges ◽  
Smart Drug ◽  
Smart Drug Delivery

Background: Nanotechnology has contributed a great deal to the field of medical science. Smart drugdelivery vectors, combined with stimuli-based characteristics, are becoming increasingly important. The use of external and internal stimulating factors can have enormous benefits and increase the targeting efficiency of nanotechnology platforms. The pH values of tumor vascular tissues are acidic in nature, allowing the improved targeting of anticancer drug payloads using drug-delivery vectors. Nanopolymers are smart drug-delivery vectors that have recently been developed and recommended for use by scientists because of their potential targeting capabilities, non-toxicity and biocompatibility, and make them ideal nanocarriers for personalized drug delivery. Method: The present review article provides an overview of current advances in the use of nanoparticles (NPs) as anticancer drug-delivery vectors. Results: This article reviews the molecular basis for the use of NPs in medicine, including personalized medicine, personalized therapy, emerging vistas in anticancer therapy, nanopolymer targeting, passive and active targeting transports, pH-responsive drug carriers, biological barriers, computer-aided drug design, future challenges and perspectives, biodegradability and safety. Conclusions: This article will benefit academia, researchers, clinicians, and government authorities by providing a basis for further research advancements.

scholarly journals Microbubble generation in phase-shift nanoemulsions used as anticancer drug carriers

2009 ◽  
Vol 1 (1-2) ◽  
pp. 31-39 ◽  
Author(s):  
N. Y. Rapoport ◽  
A. L. Efros ◽  
D. A. Christensen ◽  
A. M. Kennedy ◽  
K.-H. Nam
Keyword(s):  
Phase Shift ◽  
Anticancer Drug ◽  
Drug Carriers

Stimuli-Sensitive Polymeric Micelles as Anticancer Drug Carriers

2006 ◽  
Vol 6 (6) ◽  
pp. 525-535 ◽  
Author(s):  
Kun Na ◽  
Vijay Sethuraman ◽  
You Han Bae ◽  
Vijay Sethuraman
Keyword(s):  
Anticancer Drug ◽  
Polymeric Micelles ◽  
Drug Carriers ◽  
Stimuli Sensitive

Biocompatible Zr-based nanoscale MOFs coated with modified poly(ε-caprolactone) as anticancer drug carriers

2016 ◽  
Vol 509 (1-2) ◽  
pp. 208-218 ◽  
Author(s):  
Maria Filippousi ◽  
Stuart Turner ◽  
Karen Leus ◽  
Panoraia I. Siafaka ◽  
Eirini D. Tseligka ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Drug Carriers

Naturally derived DNA nanogels as pH- and glutathione-triggered anticancer drug carriers

2020 ◽  
Vol 114 ◽  
pp. 111025 ◽  
Author(s):  
Yu-Fon Chen ◽  
Ming-Wei Hsu ◽  
Yu-Chu Su ◽  
Ho-Min Chang ◽  
Chien-Hsiang Chang ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Drug Carriers

Enzymatic synthesis of poly(ω-pentadecalactone-co-butylene-co-3,3′-dithiodipropionate) copolyesters and self-assembly of the PEGylated copolymer micelles as redox-responsive nanocarriers for doxorubicin delivery

2015 ◽  
Vol 6 (11) ◽  
pp. 1997-2010 ◽  
Author(s):  
Bo Liu ◽  
Xiaofang Zhang ◽  
Ya Chen ◽  
Zhicheng Yao ◽  
Zhe Yang ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Self Assembly ◽  
Enzymatic Synthesis ◽  
Drug Carriers ◽  
Redox Responsive ◽  
Copolymer Micelles ◽  
Doxorubicin Delivery

The PEG-polyester copolymers bearing disulfide groups were synthesized to serve as redox-responsive anticancer drug carriers with an enhanced efficacy.

Partitioning of prototropic species of an anticancer drug ellipticine in bile salt aggregates of different head groups and hydrophobic skeletons: a photophysical study to probe bile salts as multisite drug carriers

2014 ◽  
Vol 16 (29) ◽  
pp. 15681-15691 ◽  
Author(s):  
Raina Thakur ◽  
Anupam Das ◽  
Chandan Adhikari ◽  
Anjan Chakraborty
Keyword(s):  
Fluorescence Spectroscopy ◽  
Bile Salt ◽  
Anticancer Drug ◽  
Bile Salts ◽  
Drug Carriers ◽  
Head Groups ◽  
Photophysical Study

The entrapment and photodynamics of an anticancer drug ellipticine in different bile salt aggregates have been investigated using fluorescence spectroscopy.

Peptide modified gold nanoparticles for improved cellular uptake, nuclear transport, and intracellular retention

Nanoscale ◽  
2014 ◽  
Vol 6 (20) ◽  
pp. 12026-12033 ◽  
Author(s):  
C. Yang ◽  
J. Uertz ◽  
D. Yohan ◽  
B. D. Chithrani
Keyword(s):  
Gold Nanoparticles ◽  
Radiation Dose ◽  
Hyperspectral Imaging ◽  
Anticancer Drug ◽  
Cellular Uptake ◽  
Imaging Technique ◽  
Cancer Therapeutics ◽  
Drug Carriers ◽  
Nuclear Targeting ◽  
First Time

A novel hyperspectral imaging technique is used to image GNPs: a combination of three peptides is used for efficient nuclear targeting and improved retention of GNPs targeted into the nucleus is shown for the first time. This is important for future cancer therapeutics as GNPs can be used as radiation dose enhancers and anticancer drug carriers.

Preferred Position and Orientation of Anticancer Drug Cisplatin During Encapsulation Into Single-Walled Carbon Nanotubes

2012 ◽  
Vol 3 (1) ◽  
Author(s):  
R. Ansari ◽  
E. Kazemi ◽  
E. Mahmoudinezhad ◽  
F. Sadeghi
Keyword(s):  
Carbon Nanotubes ◽  
Side Effects ◽  
Anticancer Drug ◽  
Equilibrium Condition ◽  
Hybrid Approach ◽  
Single Walled Carbon Nanotubes ◽  
Drug Carriers ◽  
Single Walled Carbon ◽  
Chemotherapy Drugs ◽  
Walled Carbon Nanotubes

Cisplatin is one of the most widely prescribed chemotherapy drugs to treat different types of cancers. However, this anticancer drug has a number of side effects such as kidney and nerve damages, anaphylactic reactions, hearing loss, nausea, and vomiting that strongly restrict its function. In the present study, single-walled carbon nanotubes (SWCNTs) are used as protective drug carriers which can decrease these severe side effects to some extent. Using the hybrid discrete-continuum model in conjunction with Lennard-Jones potential, new semi-analytical expressions in terms of single integrals are given to evaluate van der Waals (vdW) potential energy and interaction force between an offset cisplatin and a SWCNT. In addition, molecular dynamics (MD) simulations are conducted to validate the results of such a hybrid approach. The preferred location and orientation of cisplatin while entering SWCNTs are determined. It is shown that the equilibrium condition of the drug may be affected by the radius of nanotube, the orientation of cisplatin, and the distance between the central molecule of the drug (Pt) and the left end of nanotube. Furthermore, the influence of equilibrium condition on the distributions of vdW interactions is investigated.

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