An amphiphilic block copolymer conjugated with carborane and a NIR fluorescent probe for potential imaging-guided BNCT therapy

2016 ◽  
Vol 7 (26) ◽  
pp. 4411-4418 ◽  
Author(s):  
Zheng Ruan ◽  
Le Liu ◽  
Liyi Fu ◽  
Tao Xing ◽  
Lifeng Yan
Keyword(s):  
Block Copolymer ◽  
Fluorescent Probe ◽  
Triblock Copolymer ◽  
Near Infrared ◽  
Chain Transfer ◽  
Fluorescence Probe ◽  
Reversible Addition ◽  
Nir Fluorescence ◽  
Ring Open ◽  
Nir Dye

A carborane-containing triblock copolymer conjugated with a near infrared (NIR) fluorescence probe has been synthesized via reversible addition fragmentation chain transfer (RAFT), ring open polymerization (ROP), and conjugations of a cyanine NIR dye.

Mixed polymeric micelles as a multifunctional visual thermosensor for the rapid analysis of mixed metal ions with Al3+ and Fe3+

2018 ◽  
Vol 42 (15) ◽  
pp. 12853-12864 ◽  
Author(s):  
Juan Han ◽  
Yunfeng Cai ◽  
Yun Wang ◽  
Xiaohui Dai ◽  
Lei Wang ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Metal Ions ◽  
Chain Transfer ◽  
Polymeric Micelles ◽  
Raft Polymerization ◽  
Rapid Analysis ◽  
Mixed Metal ◽  
Reversible Addition ◽  
Mixed Polymeric Micelles

A novel type of responsive mixed double hydrophilic block copolymer (DHBC)-based multifunctional visual thermosensor for the detection of Al3+ and Fe3+ was designed and synthesized based on reversible addition fragmentation chain transfer (RAFT) polymerization.

scholarly journals Detection of early neoplasia in Barrett’s esophagus using lectin-based near-infrared imaging: an ex vivo study on human tissue

Endoscopy ◽  
2018 ◽  
Vol 50 (06) ◽  
pp. 618-625 ◽  
Author(s):  
André Neves ◽  
Massimiliano Di Pietro ◽  
Maria O’Donovan ◽  
Dale Waterhouse ◽  
Sarah Bohndiek ◽  
...  
Keyword(s):  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Near Infrared ◽  
Infrared Imaging ◽  
Ex Vivo ◽  
Sampling Error ◽  
Nir Light ◽  
Nir Imaging ◽  
Nir Fluorescence ◽  
Nir Dye

Abstract Background and study aims Endoscopic surveillance for Barrett’s esophagus (BE) is limited by long procedure times and sampling error. Near-infrared (NIR) fluorescence imaging minimizes tissue autofluorescence and optical scattering. We assessed the feasibility of a topically applied NIR dye-labeled lectin for the detection of early neoplasia in BE in an ex vivo setting. Methods Consecutive patients undergoing endoscopic mucosal resection (EMR) for BE-related early neoplasia were recruited. Freshly collected EMR specimens were sprayed at the bedside with fluorescent lectin and then imaged. Punch biopsies were collected from each EMR under NIR light guidance. We compared the fluorescence intensity from dysplastic and nondysplastic areas within EMRs and from punch biopsies with different histological grades. Results 29 EMR specimens were included from 17 patients. A significantly lower fluorescence was found for dysplastic regions across whole EMR specimens (P < 0.001). We found a 41 % reduction in the fluorescence of dysplastic compared to nondysplastic punch biopsies (P < 0.001), with a sensitivity and specificity for dysplasia detection of 80 % and 82.9 %, respectively. Conclusion Lectin-based NIR imaging can differentiate dysplastic from nondysplastic Barrett’s mucosa ex vivo.

scholarly journals Folate Receptor Near-Infrared Optical Imaging Provides Sensitive and Specific Intraoperative Visualization of Nonfunctional Pituitary Adenomas

2018 ◽  
Vol 16 (1) ◽  
pp. 59-70 ◽  
Author(s):  
Steve S Cho ◽  
Ryan Zeh ◽  
John T Pierce ◽  
Jun Jeon ◽  
MacLean Nasrallah ◽  
...  
Keyword(s):  
Predictive Value ◽  
Pituitary Adenomas ◽  
Near Infrared ◽  
Folate Receptor ◽  
P Value ◽  
Fluorescence Signal ◽  
Postoperative Mri ◽  
Nir Fluorescence ◽  
Residual Neoplasm ◽  
Nir Dye

Abstract BACKGROUND Surgical resection is the primary treatment for nonfunctional (NF) pituitary adenomas, but gross-total resection is difficult to achieve in all cases. NF adenomas overexpress folate receptor alpha (FRα). OBJECTIVE To test the hypothesis that we could target FRα for highly sensitive and specific intraoperative detection of NF adenomas using near-infrared (NIR) imaging. METHODS Fourteen patients with NF pituitary adenoma were infused with the folate analog NIR dye OTL38 preoperatively. NIR fluorescence signal-to-background ratio (SBR) was recorded for each tumor during resection of the adenomas. Extent of surgery was not modified based on the presence or absence of fluorescence. Immunohistochemistry was performed to assess FRα expression in all specimens. Magnetic resonance imaging (MRI) was performed postoperatively to assess residual neoplasm. RESULTS Nine adenomas overexpressed FRα and fluoresced with a NIR SBR of 3.2 ± 0.52, whereas the 5 non-FRα-overexpressing adenomas fluoresced with an SBR of 1.5 ± 0.21. Linear regression demonstrated a significant correlation between intraoperative SBR and the FRα expression (P-value &lt; .001). Analysis of 14 margin samples revealed that the surgeon's impression of the tissue had 83% sensitivity, 100% specificity, 100% positive predictive value, and 89% negative predictive value, while NIR fluorescence had 100% for all values. NIR fluorescence accurately predicted postoperative MRI results in 78% of FRα-overexpressing patients. CONCLUSION Preoperative injection of folate-tagged NIR dye provides strong signal and visualization of NF pituitary adenomas. It is 100% sensitive and specific for detecting margin neoplasm and can predict postoperative MRI findings. Our results suggest that NIR fluorescence may be superior to white-light visualization alone and may improve resection rates in NF pituitary adenomas.

Synthesis of Polystyrene-b-poly(n-butyl acrylate)-b-Polystyrene Triblock Copolymers as Binder for Pigment Dyeing

2012 ◽  
Vol 441 ◽  
pp. 473-477
Author(s):  
Lei Yang ◽  
Cheng Jie Hu ◽  
Hai Yang ◽  
Dong Ming Qi
Keyword(s):  
Mechanical Properties ◽  
Butyl Acrylate ◽  
Triblock Copolymer ◽  
Chain Transfer ◽  
Triblock Copolymers ◽  
Polymerization Process ◽  
Fastness Properties ◽  
Copolymer Films ◽  
Reversible Addition ◽  
Dyed Fabrics

Well-controlled polystyrene-b-poly (n-butyl acrylate)-b-polystyrene (PSt-b-PnBA-b-PSt) triblock copolymers were prepared by RAFT (reversible addition-fragmentation chain transfer) emulsion polymerization process. The mechanical properties of the triblock copolymers were investigated in comparison to the P(nBA-co-St) statistical copolymers. When the PSt content is 20%, the ultimate tensile strength of triblock copolymer is nearly six times the strength of statistical copolymer, while their modulus are all around 3.0×103 Pa. The triblock copolymer films feel smooth and non-tacky as the PSt content is higher than 20%. It indicates that PSt-b-PnBA-b-PSt triblock copolymers can be used as binders in pigment dyeing, providing the dyed fabrics with soft non-tacky handle and good fastness properties.

scholarly journals A well-defined polyelectrolyte and its copolymers by reversible addition fragmentation chain transfer (RAFT) polymerization: synthesis and applications

RSC Advances ◽  
2015 ◽  
Vol 5 (119) ◽  
pp. 98559-98565 ◽  
Author(s):  
Muhammad Mumtaz ◽  
Karim Aissou ◽  
Dimitrios Katsigiannopoulos ◽  
Cyril Brochon ◽  
Eric Cloutet ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Self Assembly ◽  
Chain Transfer ◽  
Raft Polymerization ◽  
Controlled Polymerization ◽  
Reversible Addition ◽  
Block Copolymer Electrolytes

Controlled polymerization and self-assembly of novel block copolymer electrolytes.

Ethanolic RAFT Dispersion Polymerization of 2-(Naphthalen-2-yloxy)ethyl Methacrylate and 2-Phenoxyethyl Methacrylate with Poly[2-(dimethylamino)ethyl Methacrylate] Macro-Chain Transfer Agents

2015 ◽  
Vol 68 (6) ◽  
pp. 939 ◽  
Author(s):  
Yiwen Pei ◽  
Nadia C. Dharsana ◽  
Andrew B. Lowe
Keyword(s):  
Block Copolymer ◽  
Block Copolymers ◽  
Dispersion Polymerization ◽  
Chain Transfer ◽  
Narrow Range ◽  
Degree Of Polymerization ◽  
Size Exclusion ◽  
Full Spectrum ◽  
Ethyl Methacrylate ◽  
Reversible Addition

The ethanolic reversible addition-fragmentation chain transfer dispersion polymerization (RAFTDP), at 21 wt-%, of 2-(naphthalen-2-yloxy)ethyl methacrylate (NOEMA) and 2-phenoxyethyl methacrylate (POEMA) with a poly[2-(dimethylamino)ethyl methacrylate] macro-chain transfer agent (CTA) with an average degree of polymerization of 20 (PDMAEMA20) is described. DMAEMA20-b-NOEMAy (y = 20–125) block copolymers were readily prepared under dispersion conditions in ethanol at 70°C. However, the polymerization of NOEMA was not well controlled, with size exclusion chromatograms being distinctly bi or multimodal with measured dispersities . Though NOEMA copolymerization was not ideal, the resulting series of block copolymers did exhibit the anticipated full spectrum of nanoparticle morphologies (spheres, worms, and vesicles). Interestingly, these morphology transitions occurred over a relatively narrow range of block copolymer compositions. In the case of POEMA, copolymerization was also poorly controlled with 1.50 ≤ ĐM ≤ 1.83 for the series of DMAEMA20-b-POEMAy copolymers. In contrast to the NOEMA-based copolymers, the POEMA series only yielded nanoparticles with a spherical morphology whose size increased with increasing average degrees of polymerization of the POEMA block. Collectively, though both NOEMA and POEMA can be utilized in ethanolic RAFT dispersion polymerization formulations, these preliminary studies suggest that neither appears to be an ideal aryl methacrylate choice as comonomer, especially if the goal is to combine the synthesis of well-defined copolymers with efficient nanoparticle formation.

Synthesis of Zwitterionic Chimeric Polymersomes for Efficient Protein Loading and Intracellular Delivery

2021 ◽  
Author(s):  
bingbing zhao ◽  
Yuting Yan ◽  
Junmei Zhang ◽  
Enping Chen ◽  
Ke Wang ◽  
...  
Keyword(s):  
Ring Opening ◽  
Triblock Copolymer ◽  
Chain Transfer ◽  
Raft Polymerization ◽  
Intracellular Delivery ◽  
Ring Opening Polymerization ◽  
H Nmr ◽  
Protein Loading ◽  
Reversible Addition

A novel zwitterionic triblock copolymer of poly(dimethylamino carbonate)-polycaprolactone-poly((2-(methacryloyloxy)ethyl)dimethyl-(3-sulfopropyl)ammonium) [PAC(DMA)-PCL-PMDMSA] was designed and synthesized via sequential ring-opening polymerization (ROP) and reversible addition-fragmentation chain transfer (RAFT) polymerization successively. The 1H NMR and...

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