Phenylboronic acid-based amphiphilic glycopolymeric nanocarriers for in vivo insulin delivery

2016 ◽  
Vol 7 (18) ◽  
pp. 3189-3199 ◽  
Author(s):  
Honglei Guo ◽  
Hongmei Li ◽  
Juntao Gao ◽  
Guangxi Zhao ◽  
Lilu Ling ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Phenylboronic Acid ◽  
Insulin Delivery ◽  
Glucose Regulation ◽  
Global Burden ◽  
The World

Diabetes mellitus, a disorder of glucose regulation, is a global burden affecting millions of people across the world.

scholarly journals Charge-switchable polymeric complex for glucose-responsive insulin delivery in mice and pigs

2019 ◽  
Vol 5 (7) ◽  
pp. eaaw4357 ◽  
Author(s):  
Jinqiang Wang ◽  
Jicheng Yu ◽  
Yuqi Zhang ◽  
Xudong Zhang ◽  
Anna R. Kahkoska ◽  
...  
Keyword(s):  
Animal Models ◽  
Insulin Release ◽  
Phenylboronic Acid ◽  
Insulin Delivery ◽  
Fast Response ◽  
Diabetic Mouse ◽  
Glucose Sensing ◽  
Large Animal ◽  
Large Animal Models

Glucose-responsive insulin delivery systems with robust responsiveness that has been validated in animal models, especially in large animal models, remain elusive. Here, we exploit a new strategy to form a micro-sized complex between a charge-switchable polymer with a glucose-sensing moiety and insulin driven by electrostatic interaction. Both high insulin loading efficiency (95%) and loading capacity (49%) can be achieved. In the presence of a hyperglycemic state, the glucose-responsive phenylboronic acid (PBA) binds glucose instantly and converts the charge of the polymeric moiety from positive to negative, thereby enabling the release of insulin from the complex. Adjusting the ratio of the positively charged group to PBA achieves inhibited insulin release from the complex under normoglycemic conditions and promoted release under hyperglycemic conditions. Through chemically induced type 1 diabetic mouse and swine models, in vivo hyperglycemia-triggered insulin release with fast response is demonstrated after the complex is administrated by either subcutaneous injection or transdermal microneedle array patch.

scholarly journals TRIGONELLA FOENUM : A REVIEW OF HYPOGLYCEMIC ACTIVITY

2019 ◽  
Vol 19 (3) ◽  
pp. 72-76
Author(s):  
Suryawati Suryawati ◽  
Safrida Safrida ◽  
Firdausa Sarah ◽  
Azizah Vonna ◽  
Vera Dewi Mulia
Keyword(s):  
Diabetes Mellitus ◽  
Heart Disease ◽  
Folk Medicine ◽  
Hypoglycemic Agents ◽  
Glucose Regulation ◽  
Converting Enzyme ◽  
Trigonella Foenum Graecum ◽  
Treatment Of Diabetes

Treatment of diabetes mellitus is intended to reduce the risk of blindness, kidney failure, neuropathy and heart disease that can develop due to the chronic increase in the blood glucose level. The selected hypoglycemic agents should be effective, safe and readily available. The widely used agents work by interrupting enzymes responsible for glucose regulation. Those enzymes are α-amilase, α-glucosidase, dipeptidyl peptidase-IV, aldose reductase and angiotensin converting enzyme. A medicinal plant, fenugreek (Trigonella foenum-graecum) has been used as an antidiabetic folk medicine. This review provides information related to in vitro studies showing antihyperglycemic activity of fenugreek along with an in vivo study in animals. In addition, potential phytochemicals that have been isolated from this plant are described and play a role in the searching for the most potent agents for diabetes mellitus therapy.

scholarly journals Pharmacognostic, Phytochemical Analysis and Anti Diabetic Activity of Dried Leaves of Abrus precatorius – an in vivo Approach

2018 ◽  
Vol 10 (03) ◽  
Author(s):  
Narender Boggula1 ◽  
Madan Mohan Elsani ◽  
Vamshi Sharathnath Kaveti
Keyword(s):  
Diabetes Mellitus ◽  
Clinical Trials ◽  
In Vivo Studies ◽  
Phytochemical Analysis ◽  
Therapeutic Effects ◽  
Abrus Precatorius ◽  
The World ◽  
Patients With Diabetes ◽  
Different Parts

Diabetes mellitus is among the most common disorder in developed and developing countries, and the disease is increasing rapidly in most parts of the world. It has been estimated that up to one-third of patients with diabetes mellitus use some form of complementary and alternative medicine. The medicinal plants refer to the plants extracts of different parts (leaves, seeds, roots, fruits etc.) which are used in the treatment of various diseases of humans, animals and plants. So, the study was carried out to ascertain the anti diabetic properties present in different extracts of dried scale leaves of Abrus precatorius. The present study is an attempt to highlight the anti diabetic activity as well as phytochemical and pharmacological reports on Abrus precatorius and calls for better-designed clinical trials to elucidate possible therapeutic effects on diabetes. The in-vivo studies on the chloroform leaves extract of Abrus precatorius revealed the presence of significant anti diabetic activity. Therefore, it can be used as a source of natural anti diabetic and used in drug formulations for treatment of diseases.

Ciamexon in low-dose streptozotocin induced diabetes mellitus. In vivo and in vitro studies

1986 ◽  
Vol 113 (1_Suppl) ◽  
pp. S120-S121
Author(s):  
TH. LINN ◽  
H. GERMANN ◽  
B. HERING ◽  
R. BRETZEL ◽  
K. FEDERLIN
Keyword(s):  
Diabetes Mellitus ◽  
Low Dose ◽  
In Vitro Studies ◽  
Streptozotocin Induced Diabetes

Association and treatment of diabetes in patients affected by Covid-19

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1198-1201
Author(s):  
Syed Yasir Afaque
Keyword(s):  
Diabetes Mellitus ◽  
Prognostic Value ◽  
Heart Diseases ◽  
The Novel ◽  
The World ◽  
Treatment Of Diabetes ◽  
Coronavirus Infection ◽  
Composite Outcomes ◽  
Novel Coronavirus ◽  
The Impact

In December 2019, a unique coronavirus infection, SARS-CoV-2, was first identified in the province of Wuhan in China. Since then, it spread rapidly all over the world and has been responsible for a large number of morbidity and mortality among humans. According to a latest study, Diabetes mellitus, heart diseases, Hypertension etc. are being considered important risk factors for the development of this infection and is also associated with unfavorable outcomes in these patients. There is little evidence concerning the trail back of these patients possibly because of a small number of participants and people who experienced primary composite outcomes (such as admission in the ICU, usage of machine-driven ventilation or even fatality of these patients). Until now, there are no academic findings that have proven independent prognostic value of diabetes on death in the novel Coronavirus patients. However, there are several conjectures linking Diabetes with the impact as well as progression of COVID-19 in these patients. The aim of this review is to acknowledge about the association amongst Diabetes and the novel Coronavirus and the result of the infection in such patients.

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