Tuning the growth, crosslinking, and gating effect of disulfide-containing PGMAs on the surfaces of mesoporous silica nanoparticles for redox/pH dual-controlled cargo release

2016 ◽  
Vol 7 (12) ◽  
pp. 2171-2179 ◽  
Author(s):  
Hang Zhou ◽  
Xin Wang ◽  
Jun Tang ◽  
Ying-Wei Yang
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Disulfide Bond ◽  
Mesoporous Silica Nanoparticles ◽  
Gating Effect

PGMA brushes grown on MSN surfaces via SI-ATRP could be cross-linked by cystamine or through a KI/H2O2 (30%) assisted disulfide bond exchange to realize gating effects for redox/pH dual-controlled cargo release.

Redox-sensitive mesoporous silica nanoparticles functionalized with PEG through a disulfide bond linker for potential anticancer drug delivery

RSC Advances ◽  
2015 ◽  
Vol 5 (73) ◽  
pp. 59576-59582 ◽  
Author(s):  
Huameng Gong ◽  
Zhifei Xie ◽  
Mingxing Liu ◽  
Hongda Zhu ◽  
Honghao Sun
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Anticancer Drug ◽  
Disulfide Bond ◽  
Mesoporous Silica Nanoparticles ◽  
Thiol Group ◽  
Anticancer Drug Delivery ◽  
Methoxy Polyethylene Glycol

In this paper, redox-sensitive mesoporous silica nanoparticles (MSNs–SS–PEG) were successfully synthesized using silica nanoparticles modified with a thiol group (MSNs–SH) and thiol-functionalized methoxy polyethylene glycol (MeOPEG–SH).

scholarly journals Functional polymeric dialdehyde dextrin network capped mesoporous silica nanoparticles for pH/GSH dual-controlled drug release

RSC Advances ◽  
2018 ◽  
Vol 8 (37) ◽  
pp. 20862-20871 ◽  
Author(s):  
Chao Chen ◽  
Wen Sun ◽  
Wenji Yao ◽  
Yibing Wang ◽  
Hanjie Ying ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Disulfide Bond ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Release ◽  
Polymer Shell ◽  
Dual Responsive

A smart pH/GSH dual-responsive drug delivery system by using DAD as a “gatekeeper polymer” to end-cap MSNs via pH-sensitive Schiff bond, whereas DAD polymer shell were cross-linked by GSH-sensitive disulfide bond.

Recent Advances in Application of Azobenzenes Grafted on Mesoporous Silica Nanoparticles in Controlled Drug Delivery Systems Using Light as External Stimulus

2020 ◽  
Vol 20 (11) ◽  
pp. 1001-1016
Author(s):  
Sandra Ramírez-Rave ◽  
María Josefa Bernad-Bernad ◽  
Jesús Gracia-Mora ◽  
Anatoly K. Yatsimirsky
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
High Surface ◽  
Delivery Systems ◽  
Surface Reactivity ◽  
External Stimulus ◽  
Recent Advances

Hybrid materials based on Mesoporous Silica Nanoparticles (MSN) have attracted plentiful attention due to the versatility of their chemistry, and the field of Drug Delivery Systems (DDS) is not an exception. MSN present desirable biocompatibility, high surface area values, and a well-studied surface reactivity for tailoring a vast diversity of chemical moieties. Particularly important for DDS applications is the use of external stimuli for drug release. In this context, light is an exceptional alternative due to its high degree of spatiotemporal precision and non-invasive character, and a large number of promising DDS based on photoswitchable properties of azobenzenes have been recently reported. This review covers the recent advances in design of DDS using light as an external stimulus mostly based on literature published within last years with an emphasis on usually overlooked underlying chemistry, photophysical properties, and supramolecular complexation of azobenzenes.

Fluorescent spherical mesoporous silica nanoparticles loaded with emodin: Synthesis, cellular uptake and anticancer activity

2021 ◽  
Vol 119 ◽  
pp. 111619
Author(s):  
Paul Jänicke ◽  
Claudia Lennicke ◽  
Annette Meister ◽  
Barbara Seliger ◽  
Ludger A. Wessjohann ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Anticancer Activity ◽  
Silica Nanoparticles ◽  
Cellular Uptake ◽  
Mesoporous Silica Nanoparticles
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