Topical treatment of green tea polyphenols emulsified in carboxymethyl cellulose protects against acute ultraviolet light B-induced photodamage in hairless mice

2016 ◽  
Vol 15 (10) ◽  
pp. 1264-1271 ◽  
Author(s):  
Huaping Li ◽  
Na Jiang ◽  
Qing Liu ◽  
Aili Gao ◽  
Xin Zhou ◽  
...  
Keyword(s):  
Ultraviolet Light ◽  
Green Tea ◽  
Topical Application ◽  
Topical Treatment ◽  
Carboxymethyl Cellulose ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
Short Term ◽  
Hairless Mice ◽  
Ultraviolet Light B

Short-term topical application of GTPs emulsified in CMC-Na effectively prevented acute UVB (3× MEDs per day for 3 successive days) induced photodamage in hairless mice skin.

A novel approach to manage skin toxicity caused by therapeutic agents targeting epidermal growth factor receptor.

2012 ◽  
Vol 30 (4_suppl) ◽  
pp. 636-636
Author(s):  
Rossana Berardi ◽  
Anna Campanati ◽  
Azzurra Onofri ◽  
Chiara Pierantoni ◽  
Irene Conte ◽  
...  
Keyword(s):  
Green Tea ◽  
Topical Application ◽  
Life Quality ◽  
Growth Factor Receptor ◽  
Skin Toxicity ◽  
Skin Inflammation ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
Novel Approach

636 Background: Inhibition of EGFR represents an important field in cancer therapy.Skin rash is a common adverse reaction in patients receiving EGFR inhibitors. Nicotinamide has been shown to be an effective treatment for skin inflammation in various conditions, since nicotinamide inhibits IL-8 production through the NF-kB and MAPK pathways in an in vitro keratinocytes/P. acnes model of inflammation. Furthermore green tea polyphenols could be useful in attenuation of solar UVB light-induced oxidative stress-mediated and MAPK-caused skin disorders in humans.In this study we evaluated the effect of nicotinamide and green tea polyphenols on skin toxicity EGFRI related. Methods: Patients with skin toxicity induced by EGFRI were enrolled. They underwent a skin biopsy and skin samples for microbiological analyses at first presentation of skin toxicity (T0). Skin toxicity was assessed with NCI-CTACE,EGFR index and Dermatology Life Quality Index (DLQI) test. Therapy protocol consisted in topical application of moisturizing cream containing green tea polyphenols plus oral administration of nicotinamide 200 mg/die for 12 weeks. Topical application of 1% clindamycin gel and/or systemic administration of minocicline were provided in case of superbacterial infection. All treated patients were monitored for at least 12 weeks (T12), across three time points (T0,T6,T12). Results: 24 colorectal cancer patients receiving anti-EGFR monoclonal antibodies (cetuximab or panitumumab) and developing skin toxicity were treated by a multidisciplinary team including oncologists, dermatologists, a pathologist and a nurse. All the patients experienced a significant reduction of skin toxicity according to the NCI-CTACE and EGFR index (p<0.05). Papulo-pustular eruption and itching significantly improved after 6 weeks of treatment and erythema decreased after 12 weeks. A significative improvement of the global score and of DLQI was evident. No toxicity related to the treatment of skin toxicity was observed. Conclusions: Treatment with nicotinamide and green tea polyphenols represent a novel effective approach to manage skin toxicity caused by EGFRI.

Topical Green Tea Polyphenols and Caffeine as a Treatment for Acne Vulgaris

2017 ◽  
Vol 1 ◽  
pp. s55
Author(s):  
Sarah Y Siu ◽  
Georgina M Ferzli ◽  
Neil Brody
Keyword(s):  
Green Tea ◽  
Acne Vulgaris ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols

Abstract Not Available

Antimutagenic activity of green tea polyphenols

1989 ◽  
Vol 223 (3) ◽  
pp. 273-285 ◽  
Author(s):  
Zhi Y. Wang ◽  
Shu J. Cheng ◽  
Zong C. Zhou ◽  
Mohammad Athar ◽  
Wasiuddin A. Khan ◽  
...  
Keyword(s):  
Green Tea ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
Antimutagenic Activity

Supplementation with Green Tea Polyphenols Improves Bone Microstructure and Quality in Aged, Orchidectomized Rats

2011 ◽  
Vol 88 (6) ◽  
pp. 455-463 ◽  
Author(s):  
Chwan-Li Shen ◽  
Jay J. Cao ◽  
Raul Y. Dagda ◽  
Thomas E. Tenner ◽  
Ming-Chien Chyu ◽  
...  
Keyword(s):  
Green Tea ◽  
Bone Microstructure ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols

Complexation/encapsulation of green tea polyphenols in mixed calcium carbonate and phosphate micro-particles

2010 ◽  
Vol 28 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Amal Elabbadi ◽  
Nicolas Jeckelmann ◽  
Olivier P. Haefliger ◽  
Lahoussine Ouali
Keyword(s):  
Calcium Carbonate ◽  
Green Tea ◽  
Tea Polyphenols ◽  
Green Tea Polyphenols ◽  
Micro Particles
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