Post-synthetic conversion of 5-pivaloyloxymethyluridine present in a support-bound RNA oligomer into biologically relevant derivatives of 5-methyluridine

2017 ◽  
Vol 15 (9) ◽  
pp. 2097-2103 ◽  
Author(s):  
Karolina Bartosik ◽  
Elzbieta Sochacka ◽  
Grazyna Leszczynska
Keyword(s):  
Synthetic Method ◽  
Biologically Relevant ◽  
Rna Oligomers ◽  
Derivatives Of

A reliable post-synthetic method to access the modified RNA oligomers containing biologically important 5-methyluridines: mnm5U, cmnm5U, τm5U, nm5U, inm5U and cnm5U.

scholarly journals Selective Synthesis of N-Acylnortropane Derivatives in Palladium-Catalysed Aminocarbonylation

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1813
Author(s):  
László Kollár ◽  
Ádám Erdélyi ◽  
Haroon Rasheed ◽  
Attila Takács
Keyword(s):  
Synthetic Method ◽  
Selective Synthesis ◽  
Varied Structure ◽  
Biological Importance ◽  
Aryl Iodides ◽  
Palladium Catalyzed ◽  
Derivatives Of

The aminocarbonylation of various alkenyl and (hetero)aryl iodides was carried out using tropane-based amines of biological importance, such as 8-azabicyclo[3.2.1]octan-3-one (nortropinone) and 3α-hydroxy-8-azabicyclo[3.2.1]octane (nortropine) as N-nucleophile. Using iodoalkenes, the two nucleophiles were selectively converted to the corresponding amide in the presence of Pd(OAc)2/2 PPh3 catalysts. In the presence of several iodo(hetero)arenes, the application of the bidentate Xantphos was necessary to produce the target compounds selectively. The new carboxamides of varied structure, formed in palladium-catalyzed aminocarbonylation reactions, were isolated and fully characterized. In this way, a novel synthetic method has been developed for the producing of N-acylnortropane derivatives of biological importance.

scholarly journals One-Pot Synthesis of α-Substituted Acrylates

SynOpen ◽  
2018 ◽  
Vol 02 (02) ◽  
pp. 0161-0167
Author(s):  
Magdalini Matziari ◽  
Yixin Xie
Keyword(s):  
Amino Acids ◽  
Reaction Times ◽  
Synthetic Method ◽  
One Pot ◽  
Biologically Relevant ◽  
Mild Conditions ◽  
One Pot Synthesis ◽  
Acrylic Esters ◽  
Natural Amino Acids ◽  
Work Up

A simple and efficient synthetic method towards α-substituted acrylic esters has been developed using the Horner–Wadsworth–Emmons (HWE) reaction with HCHO after alkylation of phosphonoacetates in a one-pot reaction. This method allows the smooth introduction of various side-chains, such as natural amino acids and other biologically relevant substituents. The use of mild conditions, inexpensive reagents, short reaction times and simple work-up and purification steps provides an effective and general alternative to cumbersome multistep and low-yielding procedures described to date.

Two new derivatives of scandium borohydride, MSc(BH4)4, M = Rb, Cs, prepared via a one-pot solvent-mediated method

2019 ◽  
Vol 48 (31) ◽  
pp. 11829-11837 ◽  
Author(s):  
Agnieszka Starobrat ◽  
Tomasz Jaroń ◽  
Wojciech Grochala
Keyword(s):  
Pure Form ◽  
Synthetic Method ◽  
One Pot ◽  
Derivatives Of

New derivatives of scandium borohydride have been prepared in a pure form using a facile synthetic method and physicochemically characterized.

ChemInform Abstract: NEW SYNTHETIC METHOD FOR DERIVATIVES OF 1,4-DIHYDROPYRAZINES

1977 ◽  
Vol 8 (20) ◽  
pp. no-no
Author(s):  
YU. G. GOLOLOBOV ◽  
L. I. NESTEROVA
Keyword(s):  
Synthetic Method ◽  
Derivatives Of

scholarly journals A One-Step Microwave-Assisted Synthetic Method for an O/S-Chemoselective Route to Derivatives of the First Adenosine A3 PET Radiotracer

Molecules ◽  
2014 ◽  
Vol 19 (4) ◽  
pp. 4076-4082
Author(s):  
Karem Shanab ◽  
Catharina Neudorfer ◽  
Wolfgang Holzer ◽  
Markus Mitterhauser ◽  
Wolfgang Wadsak ◽  
...  
Keyword(s):  
Synthetic Method ◽  
Microwave Assisted ◽  
One Step ◽  
Derivatives Of

Adamantane derivatives of sulfonamides: sublimation, solubility, solvation and transfer processes in biologically relevant solvents

2016 ◽  
Vol 18 (13) ◽  
pp. 9281-9294 ◽  
Author(s):  
G. L. Perlovich ◽  
T. V. Volkova ◽  
A. V. Sharapova ◽  
V. P. Kazachenko ◽  
N. N. Strakhova ◽  
...  
Keyword(s):  
Adamantane Derivatives ◽  
Biologically Relevant ◽  
Transfer Processes ◽  
Derivatives Of

Eight adamantane derivatives of sulfonamides were synthesized and characterized.

scholarly journals The Search for New Antibacterial Agents among 1,2,3-Triazole Functionalized Ciprofloxacin and Norfloxacin Hybrids: Synthesis, Docking Studies, and Biological Activity Evaluation

2021 ◽  
Vol 90 (1) ◽  
pp. 2
Author(s):  
Halyna Hryhoriv ◽  
Illia Mariutsa ◽  
Sergiy M. Kovalenko ◽  
Victoriya Georgiyants ◽  
Lina Perekhoda ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Biological Activity ◽  
Antibacterial Agents ◽  
Docking Studies ◽  
Synthetic Method ◽  
Bacillus Subtilis Atcc ◽  
Resistant Strains ◽  
Derivatives Of

Among all modern antibiotics, fluoroquinolones are well known for their broad spectrums of activity and efficiency toward microorganisms and viruses. However, antibiotic resistance is still a problem, which has encouraged medicinal chemists to modify the initial structures in order to combat resistant strains. Our current work is aimed at synthesizing novel hybrid derivatives of ciprofloxacin and norfloxacin and applying docking studies and biological activity evaluations in order to find active promising molecules. We succeeded in the development of a synthetic method towards 1,2,3-triazole-substituted ciprofloxacin and norfloxacin derivatives. The structure and purity of the obtained compounds were confirmed by 1H NMR, 13C NMR, 19F NMR, LC/MS, UV-, IR- spectroscopy. Docking studies, together with in vitro research against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, Bacillus subtilis ATCC 6633, Pseudomonas aeruginosa ATCC 27853, Candida albicans NCTC 885-653 revealed compounds in which activity exceeded the initial molecules.

Sign in / Sign up

Export Citation Format

Share Document